{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:52:07Z","timestamp":1791341527738,"version":"4.3.1"},"reference-count":0,"publisher":"The Korean Society for Reproductive Medicine","content-domain":{"domain":["ecerm.org"],"crossmark-restriction":true},"short-container-title":["Clin Exp Reprod Med"],"abstract":"<jats:p>Objective: To evaluate the efficacy of a single 150 international unit (IU) dose of follitropin alfa (FA), administered either before or after clomiphene citrate (CC), in women with unexplained infertility.Methods: This prospective interventional study included 105 patients allocated to four groups. Group 1 received CC 100 mg\/day on cycle days 3\u20137. Group 2 received a single 150-IU dose of FA on day 3, followed by CC on days 4\u20138. Group 3 received CC 100 mg\/day on days 3\u20137, followed by a single 150-IU dose of FA on day 8. Group 4 received only a single 150-IU dose of FA on day 3. The primary outcomes were pregnancy rate (PR) and risk of ovarian hyperstimulation syndrome (OHSS), and the secondary outcome was ovulation rate (OR).Results: No ovulation was observed in the single-dose FA group. Group 1 had a PR of 11.4%, an OR of 94.3%, and an OHSS risk of 5.7%. Group 2 had a PR of 3.3%, an OR of 80.8%, and an OHSS risk of 13.3%. Group 3 had a PR of 6.7%, an OR of 92.6%, and an OHSS risk of 10%. The OR was significantly higher in the CC group than in the other groups (p=0.022). However, no significant differences were observed among groups in PR or OHSS risk (p&gt;0.05).Conclusion: Adding a single dose of FA before or after CC did not improve treatment success in patients with unexplained infertility.<\/jats:p>","DOI":"10.5653\/cerm.2025.09117","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:14:58Z","timestamp":1791339298000},"update-policy":"https:\/\/doi.org\/10.5653\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of a single dose of follitropin alfa administered before or after clomiphene citrate in the treatment of unexplained infertility"],"prefix":"10.5653","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-8937","authenticated-orcid":true,"given":"Funda","family":"Da\u011f\u0131stanl\u0131","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bolu Abant \u0130zzet Baysal University, Bolu, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0745-0907","authenticated-orcid":true,"given":"Mustafa Ayhan","family":"Ekici","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bolu Abant \u0130zzet Baysal University, Bolu, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara Bozta\u015f","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bolu \u00c7a\u011fsu Hospital, Bolu, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3624","published-online":{"date-parts":[[2026,10,7]]},"container-title":["Clinical and Experimental Reproductive Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ecerm.org\/upload\/pdf\/cerm-2025-09117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:14:59Z","timestamp":1791339299000},"score":1,"resource":{"primary":{"URL":"http:\/\/ecerm.org\/journal\/view.php?doi=10.5653\/cerm.2025.09117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.5653\/cerm.2025.09117","relation":{},"ISSN":["2233-8233","2233-8241"],"issn-type":[{"value":"2233-8233","type":"print"},{"value":"2233-8241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"2025-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}}]}}