{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:38:12Z","timestamp":1792280292576,"version":"4.4.0"},"reference-count":22,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Methodol"],"abstract":"BACKGROUND<\/jats:p>\n Propofol is widely used for induction in glioma surgery for its neuroprotective effects and favorable recovery profile. However, its dose-dependent hypotension is a major limitation in procedures requiring stable cerebral perfusion.<\/jats:p>\n AIM<\/jats:p>\n To compare the efficacy of propofol vs propofol-phenylephrine (PPE) combination in maintaining hemodynamic stability in patients undergoing glioma surgery.<\/jats:p>\n METHODS<\/jats:p>\n Ninety American Society of Anesthesiologists I-II patients scheduled for elective glioma surgery were randomized to receive either propofol (group P) or a PPE admixture (group PPE). Induction was performed with slow titration of the study drug until loss of verbal response and Bispectral index < 60, followed by a continuous infusion (50 \u03bcg\/kg\/minute) until skin closure. Hemodynamic parameters [mean arterial pressure (MAP), systolic blood pressure, diastolic blood pressure, and heart rate] were recorded at baseline, during induction, immediately after intubation, and at predefined intraoperative time points. The incidence of hypotension, vasopressor and esmolol use, and brain relaxation scores were compared.<\/jats:p>\n RESULTS<\/jats:p>\n Group PPE demonstrated significantly better preservation of MAP, systolic blood pressure, diastolic blood pressure, and heart rate throughout the peri-induction and intraoperative periods (P < 0.05). The mean maximum MAP reduction during induction was greater in group P compared with group PPE (19.7 mmHg vs 12.5 mmHg; P < 0.01). Hypotensive episodes were significantly more frequent in group P than in group PPE (84.4% vs 6.7%; P < 0.001). Rescue phenylephrine requirements were markedly lower in group PPE (P < 0.001). Esmolol use and brain relaxation scores were comparable between groups.<\/jats:p>\n CONCLUSION<\/jats:p>\n Adding phenylephrine to propofol for induction and maintenance provides superior hemodynamic stability without compromising brain relaxation in glioma surgery.<\/jats:p>","DOI":"10.5662\/wjm.117220","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:38:40Z","timestamp":1780414720000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of propofol alone\n vs<\/i>\n propofol-phenylephrine combination for intraoperative hemodynamic stability in glioma surgery"],"prefix":"10.5662","volume":"16","author":[{"given":"Rhea","family":"Thotungal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Kaushal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Waindeskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudrashish","family":"Haldar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pfokreni","family":"Lokho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.92.1.0001"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1996.13.681"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-9302-0_21"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/01.aco.0000245274.69292.ad"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1177\/00368504211052354"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200309000-00015"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199909000-00027"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.31729\/jnma.6752"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_320_19"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-013-9902-6"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199550030-00008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2008.00043.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2007.00015.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199306000-00002"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1986.tb13271.x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:4:1:054"},{"key":"B17","unstructured":"Imran M, Khan FH, Khan MA. Attenuation of hypotension using phenylephrine during induction of anaesthesia with propofol. J Pak Med Assoc 2007; 543-547"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_346_19"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.169083"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/diseases13010005"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-018-0126-3"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.74397"}],"container-title":["World Journal of Methodology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2222-0682\/full\/v16\/i3\/117220.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2222-0682\/full\/v16\/i3\/117220.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:14:09Z","timestamp":1783664049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2222-0682\/full\/v16\/i3\/117220.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":22,"journal-issue":{"issue":"3"},"alternative-id":["117220"],"URL":"https:\/\/doi.org\/10.5662\/wjm.117220","relation":{},"ISSN":["2222-0682"],"issn-type":[{"value":"2222-0682","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,20]]}}}