{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:12:41Z","timestamp":1783667561972,"version":"3.55.0"},"reference-count":36,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Methodol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Glucagon-like peptide receptors-1 agonists (GLP-1 agonists) have revolutionized the treatment of obesity and diabetes due to their potent effects on weight and glycemic control, and cardiorenal protection. However, emerging reports and post-marketing surveillance have raised concerns regarding erectile dysfunction (ED) or impotence in a subset of male patients.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To assess the association between GLP-1 agonists, ED, total (TT) and free testosterone (FT), sex hormone binding globulins (SHBG), luteinizing hormone (LH), and follicular stimulating hormone (FSH).<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>We systematically searched PubMed, Google Scholar, and Web of Science in November and December 2026 for articles examining the association between GLP-1 agonists and ED, with no publication date restriction. However, only articles published in the English language were eligible. The terms used were GLP-1 agonists, ED, semaglutide, liraglutide, ozympic, tirzepatide, dulaglutide, and Impotence.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>One hundred seventy-two articles were found; after removing duplicates, 63 remained, of which 12 full texts were screened, and 7 studies were included in the final meta-analysis. Seven studies involving 237 males were included. GLP-1 agonist therapy improved ED score with a significant statistical difference, MD = 2.73, 95% confidence interval (CI): 1.64-3.83. A significant increase was found regarding TT, SHBG, and FSH, MD 73.04, 95%CI: 16.91-129.17, MD 7.00, 95%CI: 1.71-12.30, and MD 0.46, 95%CI: 0.01-0.91 respectively.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>No significant differences were evident regarding the FT, and LH. GLP-1 agonists significantly improved ED, TT, SHBG, and FSH in males, no effects were observed on FT, and LH; larger randomized trials are needed.<\/jats:p>","DOI":"10.5662\/wjm.119385","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:38:40Z","timestamp":1780414720000},"source":"Crossref","is-referenced-by-count":0,"title":["Glucagon-like receptor-1 agonists and impotence: A meta-analysis"],"prefix":"10.5662","volume":"16","author":[{"given":"Hyder Osman","family":"Mirghani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asawir Mohammed","family":"AlQurashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.733434"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13403"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.05.008"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1344191"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.47391\/JPMA.24-91"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.12.012"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031882"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19897"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101102"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13206134"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101103"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1159\/000499249"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1215356"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2024.0045.R1.03072024"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900857"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.androl.2020.12.001"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13405"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3494"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12099"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12754"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-025-01425-9"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105284"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13519"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S503216"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/andr.70022"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-023-02237-7"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.180026"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.70014"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2015.992722"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2025.2601423"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-025-02005-0"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020672"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1972"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1159\/000526808"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d7771"}],"container-title":["World Journal of Methodology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2222-0682\/full\/v16\/i3\/119385.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2222-0682\/full\/v16\/i3\/119385.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:14:30Z","timestamp":1783664070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2222-0682\/full\/v16\/i3\/119385.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":36,"journal-issue":{"issue":"3"},"alternative-id":["119385"],"URL":"https:\/\/doi.org\/10.5662\/wjm.119385","relation":{},"ISSN":["2222-0682"],"issn-type":[{"value":"2222-0682","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,20]]}}}