{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:05:38Z","timestamp":1763705138195},"reference-count":84,"publisher":"Baishideng Publishing Group Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJM"],"published-print":{"date-parts":[[2016]]},"DOI":"10.5662\/wjm.v6.i1.56","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T23:30:07Z","timestamp":1458257407000},"page":"56","source":"Crossref","is-referenced-by-count":9,"title":["Quo vadis motor neuron disease?"],"prefix":"10.5662","volume":"6","author":[{"given":"Rubika","family":"Balendra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rickie","family":"Patani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1973.sp010369"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Kuffler SW, Hunt CC, Quilliam JP. Function of medullated small-nerve fibers in mammalian ventral roots; efferent muscle spindle innervation. J Neurophysiol 1951;14:29-54.","DOI":"10.1152\/jn.1951.14.1.29"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1951.sp004573"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014137"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Burke RE, Strick PL, Kanda K, Kim CC, Walmsley B. Anatomy of medial gastrocnemius and soleus motor nuclei in cat spinal cord. J Neurophysiol 1977;40:667-680.","DOI":"10.1152\/jn.1977.40.3.667"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-4-42"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1960.tb02070.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906809106"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00312979"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Swash M, Fox KP. The pathology of the human muscle spindle: effect of denervation. J Neurol Sci 1974;22:1-24.","DOI":"10.1016\/0022-510X(74)90050-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/109.5.939"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.05.006"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Radunovi\u0107 A, Mitsumoto H, Leigh PN. Clinical care of patients with amyotrophic lateral sclerosis. Lancet Neurol 2007;6:913-925.","DOI":"10.1016\/S1474-4422(07)70244-2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/35097565"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Alonso A, Logroscino G, Jick SS, Hern&aacute;n MA. Incidence and lifetime risk of motor neuron disease in the United Kingdom: a population-based study. Eur J Neurol 2009;16:745-751.","DOI":"10.1111\/j.1468-1331.2009.02586.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3584"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.10.009"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1022-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006981.pub2"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080\/14660820050515539"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90191-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2007.09.143"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802521126"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.8.1171"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.254"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2014.964258"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304019"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1042"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl172"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Mills KR, Nithi KA. Corticomotor threshold is reduced in early sporadic amyotrophic lateral sclerosis. Muscle Nerve 1997;20:1137-1141.","DOI":"10.1002\/(SICI)1097-4598(199709)20:9<1137::AID-MUS7>3.0.CO;2-9"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.04.023"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00014-9"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.12.26"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr351"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306865"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2014.897357"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.872149"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306589"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310176"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.188151"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.7.995"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.033"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172911.39167.b6"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bc01a4"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bc0141"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21556"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03501.x"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000135"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2577"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.05.003"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.02.004"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006;314:130-133.","DOI":"10.1126\/science.1134108"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104236200"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Buratti E, Brindisi A, Pagani F, Baralle FE. Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of exon 9: a functional link with disease penetrance. Am J Hum Genet 2004;74:1322-1325.","DOI":"10.1086\/420978"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Mercado PA, Ayala YM, Romano M, Buratti E, Baralle FE. Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. Nucleic Acids Res 2005;33:6000-6010.","DOI":"10.1093\/nar\/gki897"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0612-2"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154584"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165942"},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 2011;72:245-256.","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Renton AE, Majounie E, Waite A, Sim&oacute;n-S&aacute;nchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 2011;72:257-268.","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Pasinelli P, Brown RH. Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci 2006;7:710-723.","DOI":"10.1038\/nrn1971"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Valdmanis PN, Kabashi E, Dyck A, Hince P, Lee J, Dion P, D&rsquo;Amour M, Souchon F, Bouchard JP, Salachas F. Association of paraoxonase gene cluster polymorphisms with ALS in France, Quebec, and Sweden. Neurology 2008;71:514-520.","DOI":"10.1212\/01.wnl.0000324997.21272.0c"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Valdmanis PN, Kabashi E, Dion PA, Rouleau GA. ALS predisposition modifiers: knock NOX, who&rsquo;s there? SOD1 mice still are. Eur J Hum Genet 2008;16:140-142.","DOI":"10.1038\/sj.ejhg.5201961"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256800"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254917"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Yamanaka K, Boillee S, Roberts EA, Garcia ML, McAlonis-Downes M, Mikse OR, Cleveland DW, Goldstein LS. Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc Natl Acad Sci USA 2008;105:7594-7599.","DOI":"10.1073\/pnas.0802556105"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH, Takahashi R, Misawa H, Cleveland DW. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci 2008;11:251-253.","DOI":"10.1038\/nn2047"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Boill&eacute;e S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 2006;312:1389-1392.","DOI":"10.1126\/science.1123511"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314085111"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1957"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07825.x"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1216"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007327"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.154"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.11.006"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2435"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1038\/nature07677"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.09.017"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.04.003"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007529"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.015"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3049"}],"container-title":["World Journal of Methodology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/2222-0682\/full\/v6\/i1\/56.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T13:24:30Z","timestamp":1567689870000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/2222-0682\/full\/v6\/i1\/56.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.5662\/wjm.v6.i1.56","relation":{},"ISSN":["2222-0682"],"issn-type":[{"value":"2222-0682","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}