{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T13:39:47Z","timestamp":1784986787650,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Sleep Med"],"published-print":{"date-parts":[[2018,6,15]]},"DOI":"10.5664\/jcsm.7146","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T15:03:59Z","timestamp":1528988639000},"page":"909-914","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["PRO: Persistent Central Sleep Apnea\/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is a Compensatory Mechanism and Should Not Be Suppressed"],"prefix":"10.1007","volume":"14","author":[{"given":"Matthew T.","family":"Naughton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"issue":"2","key":"1406002_CR1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/resp.12964","volume":"22","author":"MT Naughton","year":"2017","unstructured":"Naughton MT, Kee K Sleep apnoea in heart failure: to treat or not to treat? Respirology. 2017;22(2):217-229. PMID: 27998040.","journal-title":"Respirology"},{"issue":"2","key":"1406002_CR2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1183\/09031936.98.12020495","volume":"12","author":"P Solin","year":"1998","unstructured":"Solin P, Snell GI, Williams TJ, Naughton MT Central sleep apnoea in congestive heart failure despite vagal denervation after bilateral lung transplantation. Eur Respir J. 1998;12(2):495-498. PMID: 9727808.","journal-title":"Eur Respir J"},{"issue":"6","key":"1406002_CR3","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1172\/JCI106943","volume":"51","author":"DD Heistad","year":"1972","unstructured":"Heistad DD, Wheeler RC, Mark AL, Schmid PG, Abboud FM Effects of adrenergic stimulation on ventilation in man. J Clin Invest. 1972;51(6):1469-1475. PMID: 4336940.","journal-title":"J Clin Invest"},{"issue":"10","key":"1406002_CR4","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1161\/01.CIR.0000056520.17353.4F","volume":"107","author":"D Mansfield","year":"2003","unstructured":"Mansfield D, Kaye DM, Brunner La Rocca H, Solin P, Esler MD, Naughton MT Raised sympathetic nerve activity in heart failure and central sleep apnea is due to heart failure severity. Circulation. 2003;107(10):1396-1400. PMID: 12642360.","journal-title":"Circulation"},{"issue":"4","key":"1406002_CR5","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1152\/jappl.1999.86.4.1273","volume":"86","author":"SY Sun","year":"1999","unstructured":"Sun SY, Wang W, Zucker IH, Schultz HD Enhanced activity of carotid body chemoreceptors in rabbits with heart failure: role of nitric oxide. J Appl Physiol. 1999;86(4):1273-1282. PMID: 10194213.","journal-title":"J Appl Physiol"},{"issue":"11","key":"1406002_CR6","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1164\/rccm.201508-1555OC","volume":"193","author":"K Kee","year":"2016","unstructured":"Kee K, Stuart-Andrews C, Ellis MJ et al. Increased dead space ventilation mediates reduced exercise capacity in systolic heart failure. Am J Respir Crit Care Med. 2016;193(11):1292-1300. PMID: 26735905.","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"1406002_CR7","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1161\/CIR.0000000000000509","volume":"136","author":"CW Yancy","year":"2017","unstructured":"Yancy CW, Jessup M, Bozkurt B et al. 2017 ACC\/AHA\/HFSA focused update of the 2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation. 2017;136(6):e137-e161. PMID: 28455343.","journal-title":"Circulation"},{"key":"1406002_CR8","first-page":"A1792","volume":"122","author":"SA Mirzoyev","year":"2010","unstructured":"Mirzoyev SA, Edwards WD, Mohammed SF et al. Cardiac amyloid deposition is common in elderly patients with heart failure and preserved ejection fraction [abstract]. Circulation. 2010;122:A1792.","journal-title":"Circulation"},{"key":"1406002_CR9","first-page":"A3892","volume":"189","author":"K Kee","year":"2014","unstructured":"Kee K, Sands S, Stuart-Andrews C et al. Effect of apnea type on work of breathing and respiratory fatigability during sleep in humans with heart failure [abstract]. Am J Respir Crit Care Med. 2014;189:A3892.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"1406002_CR10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1164\/ajrccm.153.1.8542129","volume":"153","author":"JT Granton","year":"1996","unstructured":"Granton JT, Naughton MT, Benard DC, Liu PP, Goldstein RS, Bradley TD CPAP improves inspiratory muscle strength in patients with heart failure and central sleep apnea. Am J Respir Crit Care Med. 1996;153(1):277-282. PMID: 8542129.","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"1406002_CR11","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1001\/jama.1976.03270120022018","volume":"236","author":"JM Criley","year":"1976","unstructured":"Criley JM, Blaufuss AH, Kissel GL Cough-induced cardiac compression. Self-administered from of cardiopulmonary resuscitation. JAMA. 1976;236(11):1246-1250. PMID: 989068.","journal-title":"JAMA"},{"issue":"4","key":"1406002_CR12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1164\/rccm.201205-0894OC","volume":"187","author":"D Yumino","year":"2010","unstructured":"Yumino D, Kasai T, Kimmerly D, Amirthalingam V, Floras JS, Bradley TD Differing effects of obstructive and central sleep apneas on stroke volume in patients with heart failure. Am J Respir Crit Care Med. 2010;187(4):433-438.","journal-title":"Am J Respir Crit Care Med"},{"key":"1406002_CR13","first-page":"343","volume":"10","author":"OH Bing","year":"1975","unstructured":"Bing OH, Apstein CS, Brooks WW Factors influencing tolerance of cardiac muscle to hypoxia. Recent Adv Stud Cardiac Struct Metab. 1975; 10:343-354. PMID: 1831.","journal-title":"Recent Adv Stud Cardiac Struct Metab"},{"issue":"12","key":"1406002_CR14","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1164\/rccm.200503-409OC","volume":"171","author":"T Brack","year":"2005","unstructured":"Brack T, Jubran A, Laghi F, Tobin MJ Fluctuations in end-expiratory lung volume during Cheyne-Stokes respiration. Am J Respir Crit Care Med. 2005;171(12):1408-1413. PMID: 15778489.","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"1406002_CR15","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1152\/jappl.1995.78.5.1806","volume":"78","author":"MS Badr","year":"1995","unstructured":"Badr MS, Toiber F, Skatrud JB, Dempsey J Pharyngeal narrowing\/occlusion during central sleep apnea. J Appl Physiol. 1995;78(5):1806-1815. PMID: 7649916.","journal-title":"J Appl Physiol"},{"issue":"11","key":"1406002_CR16","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1093\/sleep\/30.11.1509","volume":"30","author":"I Szollosi","year":"2007","unstructured":"Szollosi I, Krum H, Kaye D, Naughton MT Sleep apnea in heart failure increases heart rate variability and sympathetic dominance. Sleep. 2007;30(11):1509-1514. PMID: 18041483.","journal-title":"Sleep"},{"issue":"8","key":"1406002_CR17","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1056\/NEJM199608223350805","volume":"335","author":"S Javaheri","year":"1996","unstructured":"Javaheri S, Parker TJ, Wexler L, Liming JD, Lindower P, Roselle GA Effect of theophylline on sleep-disordered breathing in heart failure. N Engl J Med. 1996;335(8):562-567. PMID: 8678934.","journal-title":"N Engl J Med"},{"issue":"2","key":"1406002_CR18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1164\/rccm.200507-1035OC","volume":"173","author":"S Javaheri","year":"2006","unstructured":"Javaheri S Acetazolamide improves central sleep apnea in heart failure: a double-blind, prospective study. Am J Respir Crit Care Med. 2006;173(2):234-237. PMID: 16239622.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"1406002_CR19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1152\/jappl.1995.79.1.186","volume":"79","author":"V Jounieaux","year":"1995","unstructured":"Jounieaux V, Aubert G, Dury M, Delguste P, Rodenstein DO Effects of nasal positive-pressure hyperventilation on the glottis in normal sleeping subjects. J Appl Physiol. 1995;79(1):186-193. PMID: 7559218.","journal-title":"J Appl Physiol"},{"issue":"2","key":"1406002_CR20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2869.2006.00515.x","volume":"15","author":"I Szollosi","year":"2006","unstructured":"Szollosi I, O'Driscoll DM, Dayer MJ, Coats AJ, Morrell MJ, Simonds AK Adaptive servo-ventilation and deadspace: effects on central sleep apnoea. J Sleep Res. 2006;15(2):199-205. PMID: 16704575.","journal-title":"J Sleep Res"},{"issue":"6","key":"1406002_CR21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/sleep\/16.6.529","volume":"16","author":"DJ Biberdorf","year":"1993","unstructured":"Biberdorf DJ, Steens R, Millar TW, Kryger MH Benzodiazepines in congestive heart failure: effects of temazepam on arousability and Cheyne-Stokes respiration. Sleep. 1993;16(6):529-538. PMID: 8235237.","journal-title":"Sleep"},{"issue":"8","key":"1406002_CR22","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/sleep\/22.8.1101","volume":"22","author":"S Javaheri","year":"1999","unstructured":"Javaheri S, Ahmed M, Parker TJ, Brown CR Effects of nasal O2 on sleep-related disordered breathing in ambulatory patients with stable heart failure. Sleep. 1999;22(8):1101-1106. PMID: 10617171.","journal-title":"Sleep"},{"issue":"2","key":"1406002_CR23","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0735-1097(95)00474-2","volume":"27","author":"WA Haque","year":"1996","unstructured":"Haque WA, Boehmer J, Clemson BS, Leuenberger UA, Silber DH, Sinoway LI Hemodynamic effects of supplemental oxygen administration in congestive heart failure. J Am Coll Cardiol. 1996;27(2):353-357. PMID: 8557905.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"1406002_CR24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1378\/chest.120.2.467","volume":"120","author":"S Mak","year":"2001","unstructured":"Mak S, Azevedo ER, Liu PP, Newton GE Effect of hyperoxia on left ventricular function and filling pressures in patients with and without congestive heart failure. Chest. 2001;120(2):467-473. PMID: 11502645.","journal-title":"Chest"},{"key":"1406002_CR25","doi-asserted-by":"crossref","first-page":"d234","DOI":"10.1136\/bmj.d234","volume":"342","author":"AL Clark","year":"2011","unstructured":"Clark AL, Johnson MJ, Squire I Does home oxygen benefit people with chronic heart failure? BMJ. 2011;342:d234. PMID: 21296836.","journal-title":"BMJ"},{"issue":"10048","key":"1406002_CR26","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0140-6736(16)30961-8","volume":"388","author":"MR Costanzo","year":"2016","unstructured":"Costanzo MR, Ponikowski P, Javaheri S et al. Transvenous neurostimulation for central sleep apnoea: a randomised controlled trial. Lancet. 2016;388(10048):974-982. PMID: 27598679.","journal-title":"Lancet"},{"issue":"6","key":"1406002_CR27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/MCP.0b013e3283319a87","volume":"15","author":"K Kee","year":"2009","unstructured":"Kee K, Naughton MT Heart failure and sleep-disordered breathing: mechanisms, consequences and treatment. Curr Opin Pulm Med. 2009;15(6):565-570. PMID: 19713849.","journal-title":"Curr Opin Pulm Med"},{"issue":"4","key":"1406002_CR28","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.CIR.101.4.392","volume":"101","author":"S Javaheri","year":"2000","unstructured":"Javaheri S Effects of continuous positive airway pressure on sleep apnea and ventricular irritability in patients with heart failure. Circulation. 2000;101(4):392-397. PMID: 10653830.","journal-title":"Circulation"},{"issue":"2","key":"1406002_CR29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/cs0880173","volume":"88","author":"A De Hoyos","year":"1995","unstructured":"De Hoyos A, Liu PP, Benard DC, Bradley TD Haemodynamic effects of continuous positive airway pressure in humans with normal and impaired left ventricular function. Clin Sci. 1995;88(2):173-178. PMID: 7720341.","journal-title":"Clin Sci"},{"issue":"19","key":"1406002_CR30","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1056\/NEJMoa051001","volume":"353","author":"TD Bradley","year":"2005","unstructured":"Bradley TD, Logan AG, Kimoff RJ et al. Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med. 2005;353(19):2025-2033. PMID: 16282177.","journal-title":"N Engl J Med"},{"issue":"25","key":"1406002_CR31","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1161\/CIRCULATIONAHA.106.683482","volume":"115","author":"M Arzt","year":"2007","unstructured":"Arzt M, Floras JS, Logan AG et al. Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). Circulation. 2007;115(25):3173-3180. PMID: 17562959.","journal-title":"Circulation"},{"issue":"12","key":"1406002_CR32","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1056\/NEJMoa1506459","volume":"373","author":"MR Cowie","year":"2015","unstructured":"Cowie MR, Woehrle H, Wegscheider K et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med. 2015;373(12):1095-1105. PMID: 26323938.","journal-title":"N Engl J Med"},{"issue":"4","key":"1406002_CR33","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1164\/rccm.201511-2198ED","volume":"193","author":"TD Bradley","year":"2016","unstructured":"Bradley TD, Floras JS Adaptive servo-ventilation and the treatment of central sleep apnea in heart failure. Let's not throw the baby out with the bathwater. Am J Respir Crit Care Med. 2016;193(4):357-359. PMID: 26646208.","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Clinical Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.5664\/jcsm.7146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.5664\/jcsm.7146\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jcsm.aasm.org\/ViewAbstract.aspx?pid=31301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.5664\/jcsm.7146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T08:21:08Z","timestamp":1770366068000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.5664\/jcsm.7146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6,15]]}},"alternative-id":["1406002"],"URL":"https:\/\/doi.org\/10.5664\/jcsm.7146","relation":{},"ISSN":["1550-9389","1550-9397"],"issn-type":[{"value":"1550-9389","type":"print"},{"value":"1550-9397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,15]]},"assertion":[{"value":"29 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}