{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:18:46Z","timestamp":1781723926450,"version":"3.54.5"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Clin Sleep Med"],"published-print":{"date-parts":[[2018,6,15]]},"DOI":"10.5664\/jcsm.7158","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T15:03:59Z","timestamp":1528988639000},"page":"953-958","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Continuous Positive Airway Pressure Treatment May Improve Optic Nerve Function in Obstructive Sleep Apnea: An Electrophysiological Study"],"prefix":"10.1007","volume":"14","author":[{"given":"Claudio","family":"Liguori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Placidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giuseppina","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Izzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Ludovisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Biagio","family":"Mercuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Pierantozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"issue":"19","key":"1406008_CR1","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200005113421901","volume":"342","author":"PE Peppard","year":"2000","unstructured":"Peppard PE, Young T, Palta M, Skatrud J Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378-1384. PMID: 10805822.","journal-title":"N Engl J Med"},{"issue":"3","key":"1406008_CR2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1183\/09031936.06.00107805","volume":"28","author":"Y Peker","year":"2006","unstructured":"Peker Y, Carlson J, Hedner J Increased incidence of coronary artery disease in sleep apnoea: a long-term follow-up. Eur Respir J. 2006;28(3):596-602. PMID: 16641120.","journal-title":"Eur Respir J"},{"issue":"4","key":"1406008_CR3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1046\/j.1365-2869.1998.00120.x","volume":"7","author":"F Placidi","year":"1998","unstructured":"Placidi F, Diomedi M, Cupini LM, Bernardi G, Silvestrini M Impairment of daytime cerebrovascular reactivity in patients with obstructive sleep apnoea syndrome. J Sleep Res. 1998;7(4):288-292. PMID: 9844856.","journal-title":"J Sleep Res"},{"issue":"7","key":"1406008_CR4","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1161\/01.STR.0000019123.47840.2D","volume":"33","author":"M Silvestrini","year":"2002","unstructured":"Silvestrini M, Rizzato B, Placidi F, Baruffaldi R, Bianconi A, Diomedi M Carotid artery wall thickness in patients with obstructive sleep apnea syndrome. Stroke. 2002;33(7):1782-1785. PMID: 12105352.","journal-title":"Stroke"},{"issue":"8","key":"1406008_CR5","first-page":"1343","volume":"7","author":"BD Kent","year":"2015","unstructured":"Kent BD, McNicholas WT, Ryan S Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea. J Thorac Dis. 2015;7(8):1343-1357. PMID: 26380761.","journal-title":"J Thorac Dis"},{"issue":"6","key":"1406008_CR6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.5664\/jcsm.4766","volume":"11","author":"C Liguori","year":"2015","unstructured":"Liguori C, Romigi A, Izzi F et al. Continuous positive airway pressure treatment increases serum vitamin D levels in male patients with obstructive sleep apnea. J Clin Sleep Med. 2015;11(6):603-607. PMID: 25766695.","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"1406008_CR7","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1183\/13993003.01830-2015","volume":"47","author":"C Liguori","year":"2016","unstructured":"Liguori C, Mercuri NB, Izzi F et al. Obstructive sleep apnoea as a risk factor for osteopenia and osteoporosis in the male population. Eur Respir J. 2016;47(3):987-990. PMID: 26743487.","journal-title":"Eur Respir J"},{"key":"1406008_CR8","doi-asserted-by":"crossref","unstructured":"Liguori C, Mercuri NB, Izzi F et al. Obstructive sleep apnea is associated with early but possibly modifiable Alzheimer's disease biomarkers changes. Sleep. 2017;40 5.","DOI":"10.1093\/sleep\/zsx011"},{"issue":"8225","key":"1406008_CR9","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0140-6736(81)92140-1","volume":"1","author":"CE Sullivan","year":"1981","unstructured":"Sullivan CE, Issa FG, Berthon-Jones M, Eves L Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet. 1981;1(8225):862-865. PMID: 6112294.","journal-title":"Lancet"},{"issue":"6","key":"1406008_CR10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/sleep\/30.6.711","volume":"30","author":"TE Weaver","year":"2007","unstructured":"Weaver TE, Maislin G, Dinges DF et al. Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning. Sleep. 2007;30(6):711-719. PMID: 17580592.","journal-title":"Sleep"},{"issue":"20","key":"1406008_CR11","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1001\/jama.2012.4366","volume":"307","author":"F Barb\u00e9","year":"2012","unstructured":"Barb\u00e9 F, Dur\u00e1n-Cantolla J, S\u00e1nchez-de-la-Torre M et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA. 2012;307(20):2161-2168. PMID: 22618923.","journal-title":"JAMA"},{"key":"1406008_CR12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.sleep.2016.08.022","volume":"29","author":"C Liguori","year":"2017","unstructured":"Liguori C, Izzi F, Mercuri NB et al. Vitamin D status of male OSAS patients improved after long-term CPAP treatment mainly in obese subjects. Sleep Med. 2017;29:81-85. PMID: 27964863.","journal-title":"Sleep Med"},{"issue":"8","key":"1406008_CR13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11910-014-0465-5","volume":"14","author":"CL Fraser","year":"2014","unstructured":"Fraser CL Obstructive sleep apnea and optic neuropathy: is there a link? Curr Neurol Neurosci Rep. 2014;14(8):465. PMID: 24942500.","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"1406008_CR14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.sleep.2012.07.004","volume":"14","author":"S Moghimi","year":"2013","unstructured":"Moghimi S, Ahmadraji A, Sotoodeh H et al. Retinal nerve fiber thickness is reduced in sleep apnea syndrome. Sleep Med. 2013;14(1):53-57. PMID: 22948081.","journal-title":"Sleep Med"},{"issue":"13","key":"1406008_CR15","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1177\/1352458514542862","volume":"20","author":"EH Mart\u00ednez-Lapiscina","year":"2014","unstructured":"Mart\u00ednez-Lapiscina EH, Sanchez-Dalmau B, Fraga-Pumar E et al. The visual pathway as a model to understand brain damage in multiple sclerosis. Mult Scler. 2014;20(13):1678-1685. PMID: 25013155.","journal-title":"Mult Scler"},{"issue":"1","key":"1406008_CR16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1177\/1352458508095731","volume":"15","author":"A Niklas","year":"2009","unstructured":"Niklas A, Sebraoui H, Hess E, Wagner A, Then Bergh F Outcome measures for trials of remyelinating agents in multiple sclerosis: retrospective longitudinal analysis of visual evoked potential latency. Mult Scler. 2009;15(1):68-74. PMID: 18701569.","journal-title":"Mult Scler"},{"issue":"3","key":"1406008_CR17","first-page":"323","volume":"45","author":"RM Lisci\u0107","year":"2004","unstructured":"Lisci\u0107 RM, Brecelj J Visual evoked potentials in multiple sclerosis patients treated with interferon beta-1a. Croat Med J. 2004;45(3):323-327. PMID: 15185427.","journal-title":"Croat Med J"},{"issue":"12","key":"1406008_CR18","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1001\/archneur.1987.00520240014005","volume":"44","author":"DC Anderson","year":"1987","unstructured":"Anderson DC, Slater GE, Sherman R, Ettinger MG Evoked potentials to test a treatment of chronic multiple sclerosis. Arch Neurol. 1987;44(12):1232-1236. PMID: 3675257.","journal-title":"Arch Neurol"},{"issue":"1","key":"1406008_CR19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5665\/sleep.5308","volume":"39","author":"C Liguori","year":"2016","unstructured":"Liguori C, Palmieri MG, Pierantozzi M et al. Optic nerve dysfunction in obstructive sleep apnea: an electrophysiological study. Sleep. 2016;39(1):19-23. PMID: 26237771.","journal-title":"Sleep"},{"issue":"5","key":"1406008_CR20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.2172","volume":"8","author":"RB Berry","year":"2012","unstructured":"Berry RB, Budhiraja R, Gottlieb DJ et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med. 2012;8(5):597-619. PMID: 23066376.","journal-title":"J Clin Sleep Med"},{"issue":"6","key":"1406008_CR21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540-545. PMID: 1798888.","journal-title":"Sleep"},{"issue":"6","key":"1406008_CR22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s100720300004","volume":"23","author":"L Vignatelli","year":"2003","unstructured":"Vignatelli L, Plazzi G, Barbato A et al. Italian version of the Epworth sleepiness scale: external validity. Neurol Sci. 2003;23(6):295-300. PMID: 12624716.","journal-title":"Neurol Sci"},{"issue":"9","key":"1406008_CR23","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S1388-2457(00)00366-7","volume":"111","author":"V Parisi","year":"2000","unstructured":"Parisi V, Pierelli F, Malandrini A et al. Visual electrophysiological responses in subjects with cerebral autosomal arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Clin Neurophysiol. 2000;111(9):1582-1588. PMID: 10964068.","journal-title":"Clin Neurophysiol"},{"issue":"8","key":"1406008_CR24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1468-1331.2008.02200.x","volume":"15","author":"V Parisi","year":"2008","unstructured":"Parisi V, Gallinaro G, Ziccardi L, Coppola G Electrophysiological assessment of visual function in patients with non-arteritic ischaemic optic neuropathy. Eur J Neurol. 2008;15(8):839-845. PMID: 18557920.","journal-title":"Eur J Neurol"},{"issue":"Suppl 2","key":"1406008_CR25","first-page":"ii16","volume":"76","author":"P Walsh","year":"2005","unstructured":"Walsh P, Kane N, Butler S The clinical role of evoked potentials. J Neurol Neurosurg Psychiatry. 2005;76(Suppl 2):ii16-ii22. PMID: 15961863.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"1406008_CR26","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/sj.eye.6701573","volume":"18","author":"GE Holder","year":"2004","unstructured":"Holder GE Electrophysiological assessment of optic nerve disease. Eye. 2004;18(11):1133-1143. PMID: 15534599.","journal-title":"Eye"},{"issue":"8","key":"1406008_CR27","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00417-015-3044-9","volume":"253","author":"V Parisi","year":"2015","unstructured":"Parisi V, Centofanti M, Ziccardi L et al. Treatment with citicoline eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma. Graefes Arch Clin Exp Ophthalmol. 2015;253(8):1327-1340. PMID: 26004075.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"2","key":"1406008_CR28","first-page":"167","volume":"43","author":"F Di Censo","year":"2016","unstructured":"Di Censo F, Di Censo M, Colasante G, Bordin M, Al Oum M Bilateral nonarteritic ischemic optic neuropathy treated with HBO2 therapy: a case report of angiographic and electrodiagnostic findings. Undersea Hyperb Med. 2016;43(2):167-173. PMID: 27265994.","journal-title":"Undersea Hyperb Med"},{"issue":"3","key":"1406008_CR29","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.neuroscience.2008.06.038","volume":"155","author":"G Kalesnykas","year":"2008","unstructured":"Kalesnykas G, Tuulos T, Uusitalo H, Jolkkonen J Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models. Neuroscience. 2008;155(3):937-947. PMID: 18640247.","journal-title":"Neuroscience"},{"issue":"10","key":"1406008_CR30","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1523\/JNEUROSCI.15-10-06735.1995","volume":"15","author":"RM LoPachin","year":"1995","unstructured":"LoPachin RM, Stys PK Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation. J Neurosci. 1995;15(10):6735-6746. PMID: 7472432.","journal-title":"J Neurosci"},{"issue":"6","key":"1406008_CR31","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/jsr.12553","volume":"26","author":"HL Chen","year":"2017","unstructured":"Chen HL, Lin HC, Lu CH et al. Systemic inflammation and alterations to cerebral blood flow in obstructive sleep apnea. J Sleep Res. 2017;26(6):789-798. PMID: 28513057.","journal-title":"J Sleep Res"},{"issue":"24","key":"1406008_CR32","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1056\/NEJMoa1306187","volume":"370","author":"JA Chirinos","year":"2014","unstructured":"Chirinos JA, Gurubhagavatula I, Teff K et al. CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med. 2014;370(24):2265-2275. PMID: 24918371.","journal-title":"N Engl J Med"}],"container-title":["Journal of Clinical Sleep Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.5664\/jcsm.7158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.5664\/jcsm.7158\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/jcsm.aasm.org\/ViewAbstract.aspx?pid=31307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.5664\/jcsm.7158.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T08:21:52Z","timestamp":1770366112000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.5664\/jcsm.7158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6,15]]}},"alternative-id":["1406008"],"URL":"https:\/\/doi.org\/10.5664\/jcsm.7158","relation":{},"ISSN":["1550-9389","1550-9397"],"issn-type":[{"value":"1550-9389","type":"print"},{"value":"1550-9397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,15]]},"assertion":[{"value":"30 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}