{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:25:56Z","timestamp":1791473156534,"version":"4.3.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"DOI":"10.5665\/sleep.6030","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T19:01:42Z","timestamp":1469818902000},"page":"1601-1611","source":"Crossref","is-referenced-by-count":53,"title":["Intermittent Short Sleep Results in Lasting Sleep Wake Disturbances and Degeneration of Locus Coeruleus and Orexinergic Neurons"],"prefix":"10.1093","volume":"39","author":[{"given":"Yan","family":"Zhu","sequence":"first","affiliation":[{"name":"Center for Sleep and Circadian Neurobiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Fenik","sequence":"additional","affiliation":[{"name":"Center for Sleep and Circadian Neurobiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanxia","family":"Zhan","sequence":"additional","affiliation":[{"name":"Center for Sleep and Circadian Neurobiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Somach","sequence":"additional","affiliation":[{"name":"Center for Sleep and Circadian Neurobiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Xin","sequence":"additional","affiliation":[{"name":"Center for Sleep and Circadian Neurobiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Veasey","sequence":"additional","affiliation":[{"name":"Center for Sleep and Circadian Neurobiology and Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t2018112204145793200_B1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1152\/physrev.00032.2011","article-title":"Control of sleep and wakefulness","volume":"92","author":"Brown","year":"2012","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t2018112204145793200_B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2869.2003.00337.x","article-title":"Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study.","volume":"12","author":"Belenky","year":"2003","journal-title":"J Sleep Res"},{"key":"key\n\t\t\t\t2018112204145793200_B3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/sleep\/26.2.117","article-title":"The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation.","volume":"26","author":"Van Dongen","year":"2003","journal-title":"Sleep"},{"key":"key\n\t\t\t\t2018112204145793200_B4","first-page":"E2635","article-title":"Mechanism for Hypo cretin-mediated sleep-to-wake transitions.","author":"Carter","year":"2012"},{"key":"key\n\t\t\t\t2018112204145793200_B5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t2018112204145793200_B6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1126\/science.283.5401.549","article-title":"The role of locus coeruleus in the regulation of cognitive performance.","volume":"283","author":"Usher","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t2018112204145793200_B7","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nn.3717","article-title":"Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase.","volume":"17","author":"Sanchez-Padilla","year":"2014","journal-title":"Nat Neuro sci"},{"key":"key\n\t\t\t\t2018112204145793200_B8","first-page":"4418","article-title":"Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons.","volume":"34","author":"Zhang","year":"2014","journal-title":"J Neuro sci"},{"key":"key\n\t\t\t\t2018112204145793200_B9","first-page":"12557","article-title":"Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase.","volume":"33","author":"Obukuro","year":"2013","journal-title":"J Neuro sci"},{"key":"key\n\t\t\t\t2018112204145793200_B10","first-page":"24","article-title":"Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease.","volume":"106","author":"Sulzer","year":"2008","journal-title":"J Neuro chem"},{"key":"key\n\t\t\t\t2018112204145793200_B11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-4684-8893-7_14","article-title":"Relative quantitation of monoamine histofluorescence in young and old non-human primates.","volume":"113","author":"Sladek","year":"1978","journal-title":"Adv Exp Med Biol"},{"key":"key\n\t\t\t\t2018112204145793200_B12","first-page":"4025","article-title":"SIRT1 Regulation of wakefulness and senescence-like phenotype in wake neurons.","volume":"31","author":"Panossian","year":"2011","journal-title":"J Neuro sci"},{"key":"key\n\t\t\t\t2018112204145793200_B13","first-page":"14543","article-title":"Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment.","volume":"30","author":"Gompf","year":"2010","journal-title":"J Neuro sci"},{"key":"key\n\t\t\t\t2018112204145793200_B14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jchemneu.2008.12.008","article-title":"Noradrenergic neurons expressing Fos during waking and paradoxical sleep deprivation in the rat.","volume":"37","author":"Leger","year":"2009","journal-title":"J Chem Neuroanat"},{"key":"key\n\t\t\t\t2018112204145793200_B15","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/j.1460-9568.1995.tb01108.x","article-title":"Response to novelty and its rapid habituation in locus coeruleus neurons of the freely exploring rat.","volume":"7","author":"Vankov","year":"1995","journal-title":"Eur J Neuro sci"},{"key":"key\n\t\t\t\t2018112204145793200_B16","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/sleep\/23.8.1c","article-title":"An automated system for recording and analysis of sleep in mice.","volume":"23","author":"Veasey","year":"2000","journal-title":"Sleep"},{"key":"key\n\t\t\t\t2018112204145793200_B17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fneur.2015.00109","article-title":"Degeneration in arousal neurons in chronic sleep disruption modeling sleep apnea.","volume":"6","author":"Zhu","year":"2015","journal-title":"Front Neurol"},{"key":"key\n\t\t\t\t2018112204145793200_B18","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10522-014-9532-1","article-title":"Are there roles for brain cell senescence in aging and neurodegenerative disorders?","volume":"15","author":"Tan","year":"2014","journal-title":"Biogerontology"},{"key":"key\n\t\t\t\t2018112204145793200_B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902960102","article-title":"Unbiased stereological estimation of the number of neurons in the human hippocampus.","volume":"296","author":"West","year":"1990","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t2018112204145793200_B20","doi-asserted-by":"crossref","first-page":"426 e1","DOI":"10.1016\/j.neurobiolaging.2010.10.009","article-title":"Locus coeruleus degeneration exacerbates olfactory deficits in APP\/PS1 transgenic mice.","volume":"33","author":"Rey","year":"2012","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t2018112204145793200_B21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/cne.903210309","article-title":"Restoration of ascending noradrenergic projections by residual locus coeruleus neurons: compensatory response to neurotoxin-induced cell death in the adult rat brain.","volume":"321","author":"Fritschy","year":"2016","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t2018112204145793200_B22","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0197-4580(91)90086-Y","article-title":"Different rates of age-related loss for four murine monoaminergic neuronal populations.","volume":"12","author":"Tatton","year":"1991","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t2018112204145793200_B23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2010.01.048","article-title":"Age- and gender-specific changes of hypocretin immunopositive neurons in C57B1\/6 mice.","volume":"472","author":"Brownell","year":"2010","journal-title":"Neurosci Lett"},{"key":"key\n\t\t\t\t2018112204145793200_B24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2005.06.008","article-title":"Age-related changes in cholinergic neurons in the laterodorsal and the pedunculo-pontine tegmental nuclei of cats: a combined light and electron microscopic study.","volume":"1052","author":"Zhang","year":"2005","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t2018112204145793200_B25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/jsr.12003","article-title":"Shiftworkers report worse sleep than day workers, even in retirement.","volume":"22","author":"Monk","year":"2013","journal-title":"J Sleep Res"},{"key":"key\n\t\t\t\t2018112204145793200_B26","doi-asserted-by":"crossref","first-page":"6495","DOI":"10.1523\/JNEUROSCI.0073-14.2014","article-title":"Conditional ablation of orexin\/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function.","volume":"34","author":"Tabuchi","year":"2014","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t2018112204145793200_B27","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/jnr.22725","article-title":"Sirtl overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.","volume":"89","author":"Guo","year":"2011","journal-title":"J Neuro sci Res"},{"key":"key\n\t\t\t\t2018112204145793200_B28","doi-asserted-by":"crossref","first-page":"e11707","DOI":"10.1371\/journal.pone.0011707","article-title":"Sirtuin 3 a new target of PGC-lalpha, plays an important role in the suppression of ROS and mitochondrial biogenesis.","volume":"5","author":"Kong","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018112204145793200_B29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.redox.2013.01.006","article-title":"Lipofuscin: formation, effects and role of macroautophagy.","volume":"1","author":"Hohn","year":"2013","journal-title":"Redox Biol"},{"key":"key\n\t\t\t\t2018112204145793200_B30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.freeradbiomed.2010.12.011","article-title":"Lipofuscin inhibits the proteasome by binding to surface motifs.","volume":"50","author":"Hohn","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"key\n\t\t\t\t2018112204145793200_B31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000213722","article-title":"Lipofuscin fluorophore inhibits lysosomal protein degradation and may cause early stages of macular degeneration.","volume":"41","author":"Eidred","year":"1995","journal-title":"Gerontology"},{"key":"key\n\t\t\t\t2018112204145793200_B32","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1177\/0883073813494268","article-title":"Classification and natural history of the neuronal ceroid lipofuscinoses.","volume":"28","author":"Mink","year":"2013","journal-title":"J Child Neurol"},{"key":"key\n\t\t\t\t2018112204145793200_B33","doi-asserted-by":"crossref","first-page":"e1068978","DOI":"10.1080\/21675511.2015.1068978","article-title":"Pompe disease: Shared and unshared features of lysosomal storage disorders.","volume":"3","author":"Lim","year":"2015","journal-title":"Rare Dis"},{"key":"key\n\t\t\t\t2018112204145793200_B34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/15548627.2015.1009779","article-title":"Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease.","volume":"11","author":"Lim","year":"2015","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t2018112204145793200_B35","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/j.neurobiolaging.2015.02.025","article-title":"Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress.","volume":"36","author":"Gavilan","year":"2015","journal-title":"Neurobiol Aging"},{"key":"key\n\t\t\t\t2018112204145793200_B36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1210\/en.2013-1629","article-title":"Orexin restores aging-related brown adipose tissue dysfunction in male mice.","volume":"155","author":"Sellayah","year":"2014","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2018112204145793200_B37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.conb.2014.07.006","article-title":"Hypocretin (orexin) neuromodulation of stress and reward pathways.","volume":"29","author":"Giardino","year":"2014","journal-title":"Curr Opin Neurobiol"},{"key":"key\n\t\t\t\t2018112204145793200_B38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrn2573","article-title":"The locus coeruleus and noradrenergic modulation of cognition.","volume":"10","author":"Sara","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t2018112204145793200_B39","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1007\/s11064-012-0818-x","article-title":"Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance.","volume":"37","author":"O'Donnell","year":"2012","journal-title":"Neurochem Res"},{"key":"key\n\t\t\t\t2018112204145793200_B40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.neuint.2010.02.001","article-title":"Induced LC degeneration in APP\/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.","volume":"57","author":"Jardanhazi-Kurutz","year":"2010","journal-title":"Neurochem Int"}],"container-title":["Sleep"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/sleep\/article-pdf\/39\/8\/1601\/26674601\/aasm.39.8.1601.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T23:19:33Z","timestamp":1568243973000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/sleep\/article\/39\/8\/1601\/2706358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8,1]]}},"URL":"https:\/\/doi.org\/10.5665\/sleep.6030","relation":{},"ISSN":["0161-8105","1550-9109"],"issn-type":[{"value":"0161-8105","type":"print"},{"value":"1550-9109","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,8]]},"published":{"date-parts":[[2016,8,1]]}}}