{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:34:57Z","timestamp":1787841297301,"version":"build-2784847793"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>There is a lack of data on the safety and efficacy of peritoneal drain (PD) and chest tube (CT) in the management of effusions in stem cell transplant recipients with veno-occlusive disease (VOD). In this retrospective pediatric study, clinical outcomes and health resource utilization (HRU) were compared in 32 patients with VOD who had a PD (PD+) post-HCT versus 27 patients who did not (PD-). Nine patients also had a CT (7 PD+ and 2 PD-). PD + patients were more likely than PD-patients to have received myeloablative conditioning (100% vs. 85.2%; p = 0.04) and have severe or very severe VOD (100% vs. 56% p &lt; 0.01). Mechanical obstruction (38%) and hypotension (38%) were common complications, and 13% developed peritonitis. While the frequencies of cardiac dysfunction and acute kidney injury were comparable between both groups, respiratory support and its median duration were higher in PD + patients. The hospital and intensive care unit length of stay, albumin use, and the duration of defibrotide and albumin therapy was significantly longer in PD + patients. At a median follow-up of 1.04 years (range:0.03\u201314.6), the 2-year overall survival was similar in both groups (53.8% vs. 51.5%; p = 0.73). Although PD use was similar between 1995 and 2007 vs. 2008\u20132021; (47% vs. 58%; p = 0.65), day+100 mortality was improved in recent years (53.3% vs. 17.8%; p = 0.01), coinciding with the use of defibrotide (0% vs. 84%; p &lt; 0.01). PD in pediatric patients with VOD post-HCT, although associated with increased HRU, was safe when clinically indicated and did not adversely impact clinical outcomes.<\/jats:p>","DOI":"10.56875\/2589-0646.1066","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T11:29:24Z","timestamp":1686655764000},"page":"388-396","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Peritoneal and Pleural Drains in Pediatric Hematopoietic Cell Transplant Recipients with Veno-Occlusive Disease are Safe and Do Not Adversely Impact Clinical Outcomes"],"prefix":"10.4103","volume":"16","author":[{"given":"Hemalatha G.","family":"Rangarajan","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Blood and Marrow Transplant Transplant, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinita B.","family":"Pai","sequence":"additional","affiliation":[{"name":"College of Pharmacy, The Ohio State University, Columbus, OH, USA"},{"name":"Department of Pharmacy, Nationwide Children's Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Stanek","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Blood and Marrow Transplant Transplant, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Biostatistics Resource at Nationwide Children's Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Rush","sequence":"additional","affiliation":[{"name":"College of Pharmacy, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Naples","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misti","family":"Drope","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Blood and Marrow Transplant Transplant, Nationwide Children's Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Polishchuk","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Blood and Marrow Transplant Transplant, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolla","family":"Abu-Arja","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Blood and Marrow Transplant Transplant, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajinder PS.","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, Blood and Marrow Transplant Transplant, Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"issue":"5","key":"R4-20241211","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/hep.1840190515","article-title":"Veno-occlusive disease of the liver after marrow transplantation: histological correlates of clinical signs and symptoms","volume":"19","author":"Shulman","year":"1994","journal-title":"Hepatology"},{"issue":"3","key":"R17-20241211","first-page":"197","article-title":"Hepatic veno-occlusive disease\u2013liver toxicity syndrome after bone marrow transplantation","volume":"10","author":"Shulman","year":"1992","journal-title":"Bone Marrow Transplant"},{"issue":"8893","key":"R25-20241211","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0140-6736(94)91209-2","article-title":"Paracentesis for acute renal failure caused by hepatic veno-occlusive disease","volume":"343","author":"Saudan","year":"1994","journal-title":"Lancet"},{"issue":"6","key":"R27-20241211","first-page":"1062","article-title":"Percutaneous treatment of secondary abdominal compartment syndrome","volume":"51","author":"Corcos","year":"2001","journal-title":"J Trauma"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.56875\/2589-0646.1066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:48:57Z","timestamp":1787838537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.56875\/2589-0646.1066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.56875\/2589-0646.1066","relation":{},"ISSN":["1658-3876","2589-0646"],"issn-type":[{"value":"1658-3876","type":"print"},{"value":"2589-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"assertion":[{"value":"2022-06-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}