{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:32:57Z","timestamp":1787761977539,"version":"build-2784847793"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hemophilia A, an X-linked bleeding disorder, is caused by a complete or partial deficiency in factor VIII. Multiple factors engage in the development and progression of bleeding episodes in hemophilia patients, especially arthropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      Detection of macrophage migration inhibitory factor (MIF)-173 G\/C polymorphism in people with hemophilia A (PWH) and the possible associations between the type of\n                      <jats:italic toggle=\"yes\">MIF<\/jats:italic>\n                      gene polymorphism and selected disease-related variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>This case\u2013control study included 95 male patients with hemophilia A and 95 non-hemophiliac subjects, all aged from 2 months to 63 years.<\/jats:p>\n                    <jats:p>\n                      An allele-specific polymerase chain reaction (AS-PCR) with a multiplex technique was used to detect\n                      <jats:italic toggle=\"yes\">MIF<\/jats:italic>\n                      polymorphisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A significantly higher frequency of GG polymorphism was reported in the control group (81, 85.3%) compared to PWH (64, 67.4%), while a significantly higher frequency of GC polymorphism was found in PWH (21, 22.1%) than that in healthy subjects (10, 10.5%), P &lt; 0.05.<\/jats:p>\n                    <jats:p>The G allele polymorphism was detected in 90.0% of the control group compared to 78.4% of PWH (149 subjects), while the C allele frequency was higher in PWH (41, 21.6%) compared to that in healthy individuals (18, 10.0%), P &lt; 0.05.<\/jats:p>\n                    <jats:p>\n                      The frequencies of varied\n                      <jats:italic toggle=\"yes\">MIF<\/jats:italic>\n                      -173 polymorphisms did not show significant differences among patients with different clinical presentations or in relation to presence of inhibitors, P &gt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      MIF-173 GC polymorphism is seen in PWH more than that in healthy individuals. Further studies are required to detect additional SNPs through sequencing of the\n                      <jats:italic toggle=\"yes\">MIF<\/jats:italic>\n                      gene and to detect\n                      <jats:italic toggle=\"yes\">MIF<\/jats:italic>\n                      serum levels during bleeding episodes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.56875\/2589-0646.1091","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T05:58:03Z","timestamp":1686722283000},"page":"420-425","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Macrophage Migration Inhibitory Factor Genotype in Hemophilia a Patients"],"prefix":"10.4103","volume":"16","author":[{"given":"Murtadha A.","family":"Hadi","sequence":"first","affiliation":[{"name":"Department of Microbiology, College of Medicine, University of Basrah, GR4X+F5X, Basrah, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wijdan N.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine, University of Basrah, GR4X+F5X, Basrah, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meaad K.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Basrah, GR4X+F5X, Basrah, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,5,23]]},"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.56875\/2589-0646.1091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:12:58Z","timestamp":1787760778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.56875\/2589-0646.1091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.56875\/2589-0646.1091","relation":{},"ISSN":["1658-3876","2589-0646"],"issn-type":[{"value":"1658-3876","type":"print"},{"value":"2589-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"assertion":[{"value":"2022-06-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}