{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:21:14Z","timestamp":1790115674337,"version":"4.0.1"},"reference-count":0,"publisher":"Digital Journal of Opthalmology","issue":"2","license":[{"start":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T00:00:00Z","timestamp":1559952000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digit J Ophthalmol"],"abstract":"<jats:p>Purpose\r\nTo determine whether signs and symptoms of ocular surface disease improve after placement of a self-retained, cryopreserved amniotic membrane (CAM) in patients with Sj\u00f6gren syndrome (SS).\r\nMethods\r\nThe medical records of SS patients who received a self-retained CAM implant (Prokera or Prokera Slim; TissueTech Inc, Doral, FL) for the treatment of ocular surface disease between August 2012 and August 2016 at a single, large academic institution were reviewed retrospectively. Visual acuity, results of slit-lamp examination of the cornea and conjunctiva, and dry eye symptoms, were evaluated before and after CAM insertion.\u00a0\r\nResults\r\nA total of 6 eyes of 6 patients (all female; mean age, 62.5 \u00b1 13.0 years [range, 49-86 years]) were included. All patients were on topical medications at the time of the study and had signs of ocular surface dryness. There were reductions in corneal and\/or conjunctival staining in 5 eyes (83%) after the CAM dissolved. All patients who completed therapy (5\/5) experienced a relapse in their signs and symptoms within 1 month of removal of the CAM, with an average time to relapse of 24.6 days. Mean follow-up time was 54.5 days. Foreign body sensation and blurred vision were the most common complaints associated with the CAM implant.\u00a0\r\nConclusions\r\nIn this small case series, self-retained CAM implantation was found to be beneficial in SS patients with ocular surface disease that is refractory to standard therapies; however, we found that the effects were temporary. Future larger studies are needed to confirm these benefits.<\/jats:p>","DOI":"10.5693\/djo.01.2019.02.005","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T12:22:42Z","timestamp":1563366162000},"page":"21-25","source":"Crossref","is-referenced-by-count":20,"title":["The use of self-retained, cryopreserved amniotic membrane for the treatment of Sj\u00f6gren syndrome: a case series"],"prefix":"10.5693","volume":"25","author":[{"given":"Brian M.","family":"Shafer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Fuerst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Massaro-Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Palladino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Givnish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Macchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sulewski Sr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Orlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vatinee","family":"Bunya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3822","published-online":{"date-parts":[[2019,6,8]]},"container-title":["Digital Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/djo.harvard.edu\/index.php\/djo\/article\/download\/223\/173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/djo.harvard.edu\/index.php\/djo\/article\/download\/223\/173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T12:21:14Z","timestamp":1666700474000},"score":1,"resource":{"primary":{"URL":"https:\/\/djo.harvard.edu\/index.php\/djo\/article\/view\/223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,8]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,10,24]]}},"URL":"https:\/\/doi.org\/10.5693\/djo.01.2019.02.005","relation":{},"ISSN":["1542-8958"],"issn-type":[{"value":"1542-8958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,8]]}}}