{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:39:41Z","timestamp":1762018781423,"version":"build-2065373602"},"reference-count":0,"publisher":"Digital Journal of Opthalmology","issue":"4","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digit J Ophthalmol"],"abstract":"<jats:p>Spheroidal degeneration, involving the cornea and\/or the conjunctiva, is characterized by amber-colored homogeneous, translucent spherules in the corneal stroma, Bowman\u2019s membrane, and subepithelium. The condition has a higher prevalence in areas with extreme temperatures, low humidity, high wind, and presence of sand. We report the case of a 46-year-old man with a 10-year history of gradual progressive diminution of vision, severe blepharospasm, and photophobia. Examination revealed bilateral plaques of amber-colored nodules covering about half of the cornea. Superficial keratectomy was performed for the lesions in both eyes, leaving an epithelial defect overlying a plane of opaque cornea. Histopathology showed amorphous protein in the anterior stroma, confirming the clinical diagnosis of advanced grade 4 spheroidal degeneration. Visual acuity and other symptoms dramatically improved, and the patient was scheduled for keratoplasty.<\/jats:p>","DOI":"10.5693\/djo.02.2019.11.001","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T02:33:48Z","timestamp":1580870028000},"page":"68-71","source":"Crossref","is-referenced-by-count":4,"title":["Advanced spheroidal degeneration"],"prefix":"10.5693","volume":"25","author":[{"given":"Abdelrahman M.","family":"Elhusseiny, MD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem H.","family":"El Sheikh, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emery","family":"Jamerson, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam Y.","family":"Swaify, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed B.","family":"Araissi, MD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelaziz A.","family":"Saad, PhD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3822","published-online":{"date-parts":[[2019,12,22]]},"container-title":["Digital Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/djo.harvard.edu\/index.php\/djo\/article\/download\/86\/82","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/djo.harvard.edu\/index.php\/djo\/article\/download\/86\/82","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T19:57:25Z","timestamp":1657569445000},"score":1,"resource":{"primary":{"URL":"https:\/\/djo.harvard.edu\/index.php\/djo\/article\/view\/86"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,22]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12,31]]}},"URL":"https:\/\/doi.org\/10.5693\/djo.02.2019.11.001","relation":{},"ISSN":["1542-8958"],"issn-type":[{"type":"electronic","value":"1542-8958"}],"subject":[],"published":{"date-parts":[[2019,12,22]]}}}