{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:11:42Z","timestamp":1791335502080,"version":"4.3.1"},"reference-count":5,"publisher":"Digital Journal of Opthalmology","issue":"4","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digit J Ophthalmol"],"abstract":"<jats:p>A 23-year-old man presented with a 1-month history of a red and painful right eye, with visual acuity reduced to hand motions. Examination showed uveitis with keratic precipitates, cells and flare in the anterior chamber, and vitritis that obscured visualization of the right fundus. The following week, he was noted to have the following left-sided findings: reduced visual acuity (6\/18), painless upper eyelid edema, an elevated, pink bulbar conjunctival lesion, limitation of ocular abduction, paresthesia in the V1 and reduced sensation in the V2 distributions. Blood tests showed pancytopenia. Results from the aspirate and trephine biopsy of his bone marrow were consistent with aggressive natural killer (NK) cell leukemia, a rare cause of ocular and periocular inflammation that requires a multidisciplinary team approach to care.<\/jats:p>","DOI":"10.5693\/djo.02.2022.03.001","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T12:51:47Z","timestamp":1667220707000},"page":"116-118","source":"Crossref","is-referenced-by-count":2,"title":["A case of aggressive natural killer cell leukemia"],"prefix":"10.5693","volume":"28","author":[{"given":"Yu-Chieh","family":"Hung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Foong","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3822","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3389\/fped.2018.00292","article-title":"Aggressive NK-cell leukaemia","volume":"6","author":"Ishida","year":"2018","unstructured":"1. Ishida F. Aggressive NK-cell leukaemia. Front Pediatr 2018;6:292.","journal-title":"Front Pediatr"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"3724017","DOI":"10.1155\/2017\/3724017","article-title":"CD56-negative aggressive NK cell leukemia relapsing as multiple cranial nerve palsies: case report and literature review","volume":"2017","author":"Guerreiro","year":"2017","unstructured":"2. Guerreiro M, Pr\u00edncipe F, Teles MJ, et al. CD56-negative aggressive NK cell leukemia relapsing as multiple cranial nerve palsies: case report and literature review. Case Rep Hematol 2017;2017:3724017.","journal-title":"Case Rep Hematol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"818469","DOI":"10.1155\/2011\/818469","article-title":"Treatment of aggressive NK-cell leukemia: a case report and review of the literature","volume":"2011","author":"Boysen","year":"2011","unstructured":"3. Boysen AK, Jensen P, Johansen P, et al. Treatment of aggressive NK-cell leukemia: a case report and review of the literature. Case Rep Hematol 2011;2011:818469.","journal-title":"Case Rep Hematol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"483","DOI":"10.4103\/0377-4929.138787","article-title":"Aggressive natural killer-cell leukemia: classical presentation of a rare disease","volume":"57","author":"Jacob","year":"2014","unstructured":"4. Jacob PM, Nair RA, Nair AA. Aggressive natural killer-cell leukemia: classical presentation of a rare disease. Indian J Pathol Microbiol 2014;57:483-5.","journal-title":"Indian J Pathol Microbiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/sj.eye.6701308","article-title":"Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role","volume":"18","author":"Sharma","year":"2004","unstructured":"5. Sharma T, Grewal J, Gupta S, Murray PI. Ophthalmic manifestations of acute leukaemias: the ophthalmologist's role. Eye 2004;18:663-72.","journal-title":"Eye"}],"container-title":["Digital Journal of Ophthalmology"],"original-title":[],"link":[{"URL":"https:\/\/djo.harvard.edu\/index.php\/djo\/article\/download\/247\/188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/djo.harvard.edu\/index.php\/djo\/article\/download\/247\/188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T14:37:57Z","timestamp":1680705477000},"score":1,"resource":{"primary":{"URL":"https:\/\/djo.harvard.edu\/index.php\/djo\/article\/view\/247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,29]]},"references-count":5,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12,31]]}},"URL":"https:\/\/doi.org\/10.5693\/djo.02.2022.03.001","relation":{},"ISSN":["1542-8958"],"issn-type":[{"value":"1542-8958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,29]]}}}