{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:30:52Z","timestamp":1790951452856,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Journal of Australia"],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the feasibility of testing and treating people who inject drugs at a supervised injecting facility for hepatitis C virus (HCV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting, participants<\/jats:title><jats:p>People who inject drugs who attended the Melbourne supervised injecting facility, 30 June 2018 \u2013 30 June 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Proportion of people tested for hepatitis C; proportions of people positive for anti\u2010HCV antibody and HCV RNA, and of eligible people prescribed direct\u2010acting antiviral (DAA) treatment; sustained virological response twelve weeks or more after treatment completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4649 people who attended the supervised injecting facility during 2018\u201320, 321 were tested for hepatitis C (7%); 279 were anti\u2010HCV antibody\u2010positive (87%), of whom 143 (51%) were also HCV RNA\u2010positive. Sixty\u2010four of 321 had previously been treated for hepatitis C (20%), 21 had clinically identified cirrhosis (7%), eight had hepatitis B infections (2%), and four had human immunodeficiency virus infections (1%). In multivariate analyses, people tested for hepatitis C were more likely than untested clients to report psychiatric illness (adjusted odds ratio [aOR], 9.65; 95% confidence interval [CI], 7.26\u201312.8), not have a fixed address (aOR, 1.59; 95% CI, 1.18\u20132.14), and to report significant alcohol use (aOR, 1.57; 95% CI, 1.06\u20132.32). The median number of injecting facility visits was larger for those tested for hepatitis C (101; interquartile range [IQR], 31\u2013236) than for those not tested (20; IQR, 3\u201390). DAA treatment was prescribed for 126 of 143 HCV RNA\u2010positive clients (88%); 41 of 54 with complete follow\u2010up data were cured (76%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>People who attend supervised injecting facilities can be tested and treated for hepatitis C on site. Models that provide streamlined, convenient hepatitis C care promote engagement with treatment in a group in which the prevalence of hepatitis C is high.<\/jats:p><\/jats:sec>","DOI":"10.5694\/mja2.51885","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T06:27:36Z","timestamp":1678861656000},"page":"256-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Eliminating hepatitis C in Australia: a novel model of hepatitis C testing and treatment for people who inject drugs at a medically supervised injecting facility"],"prefix":"10.5694","volume":"218","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-1468","authenticated-orcid":false,"given":"Michael B","family":"MacIsaac","sequence":"first","affiliation":[{"name":"St Vincent's Hospital Melbourne  Melbourne VIC"},{"name":"The University of Melbourne  Melbourne 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