{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:51:18Z","timestamp":1780519878075,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Journal of Australia"],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate aldosterone and renin levels and aldosterone\u2010to\u2010renin ratios (ARRs) in young Indigenous and non\u2010Indigenous adults in the Northern Territory, and their association with blood pressure levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study; single time point sub\u2010study of two prospective birth cohort studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting, participants<\/jats:title><jats:p>Participants in the Aboriginal Birth Cohort (ABC) \u2014 born to Indigenous mothers at the Royal Darwin Hospital during 1987\u20131990 \u2014 and the Top End Cohort (TEC) \u2014 people born to non\u2010Indigenous mothers in Darwin, recruited during 2007\u20132009 \u2014 aged 32\u201335 years at the time of this sub\u2010study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Plasma aldosterone and direct renin concentrations; ARRs (positive screening test result for primary aldosteronism defined as &gt;\u200970\u2009pmol\/mU); systolic and diastolic blood pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 255 ABC (205 in remote, 50 in urban locations) and 76 TEC members participated. Median aldosterone concentration was similar for all three groups. The median renin concentration was 7.5\u2009mU\/L (interquartile range [IQR], 4.1\u201312.4\u2009mU\/L) in the TEC group, 12.4\u2009mU\/L (IQR, 5.1\u201319\u2009mU\/L) in the urban ABC group, and 29.3\u2009mU\/L (IQR, 15.0\u201352.9\u2009mU\/L) in the remote ABC group. The median ARR was 10\u2009pmol\/mU (IQR, 6\u201319\u2009pmol\/mU) in the remote ABC group, 28\u2009pmol\/mU (IQR, 16\u201370\u2009pmol\/mU) in the urban ABC group, and 43\u2009pmol\/mU (IQR, 26\u201374\u2009pmol\/mU) in the TEC group. Thirteen urban ABC participants (26%), 21 TEC participants (28%), and six people in the remote ABC group (3%) had ARR values above 70\u2009pmol\/mU. Adjusted for age and body mass index (BMI), mean systolic and diastolic blood pressure were lower for women than men in all participant groups; after adjusting for age, sex, and BMI, larger ARR was associated with higher systolic blood pressure in the TEC group but not the two ABC groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Screening test results for primary aldosteronism were positive for about one\u2010quarter of urban Indigenous and non\u2010Indigenous participants. A prospective study that includes confirmatory testing would more accurately assess the prevalence of primary aldosteronism among Indigenous Australians in the Northern Territory.<\/jats:p><\/jats:sec>","DOI":"10.5694\/mja2.52062","type":"journal-article","created":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T01:24:51Z","timestamp":1691889891000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aldosterone and renin concentrations and blood pressure in young Indigenous and <scp>non\u2010Indigenous<\/scp> adults in the Northern Territory: a cross\u2010sectional study"],"prefix":"10.5694","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-032X","authenticated-orcid":false,"given":"Elisabeth","family":"Ng","sequence":"first","affiliation":[{"name":"Monash Health  Melbourne VIC"},{"name":"Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research  VIC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella M","family":"Gwini","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research  VIC"},{"name":"Monash University  Melbourne VIC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stowasser","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital  Brisbane QLD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morag J","family":"Young","sequence":"additional","affiliation":[{"name":"Baker Heart and Diabetes Institute  Melbourne VIC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Fuller","sequence":"additional","affiliation":[{"name":"Monash Health  Melbourne VIC"},{"name":"Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research  VIC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurmeet R","family":"Singh","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research  Darwin NT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-4976","authenticated-orcid":false,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Monash Health  Melbourne VIC"},{"name":"Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research  VIC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"Australian Institute of Health and Welfare.Cardiovascular disease diabetes and chronic kidney disease. 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