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There were 33\u2009335 people with MS in Australia in 2021 and 2917 in New Zealand in 2006 and the prevalence and incidence are increasing with time. Although new treatments have substantially improved outcomes in recent decades, the treatment landscape has become increasingly complex due to the expanding number of disease\u2010modifying therapies (DMTs) and associated safety considerations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main recommendations<\/jats:title><jats:p>A total of 80 consensus recommendations were developed on the current best\u2010practice management of MS in Australia and New Zealand. Part 1 of these guidelines outlines the consensus recommendations covering domains including DMT counselling and selection, pre\u2010DMT assessments, monitoring disease activity on DMT, switching DMT, and discontinuing DMT. The remaining recommendations are outlined in Part 2, encompassing risk mitigation strategies during treatment with DMT, managing DMT in special situations (including pregnancy, postpartum, breastfeeding, active infection including COVID\u201019, and malignancy), general lifestyle measures, acute MS relapses, and symptomatic treatments for MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Changes in management as a result of the guidelines<\/jats:title><jats:p>This two\u2010part position statement provides a practical resource for clinicians on current best\u2010practice consensus recommendations for managing adults (\u2265\u200918 years old) with MS in the Australian and New Zealand health care settings. It outlines the 14 DMTs currently available through the Australian Pharmaceutical Benefits Scheme and eight through the New Zealand Pharmaceutical Schedule, including the unique efficacy, safety and monitoring considerations of each. 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