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The 5703 detected substances deemed to have contributed to death included 140 medicines. The overall FTI was 32.0 (95% confidence interval [CI], 30.6\u201333.3) deaths per million years of use; overall estimated case fatality was 1.28% (95% CI, 1.23\u20131.34%) of poisoning events. FTI and estimated case fatality (each log<jats:sub>10<\/jats:sub> transformed) were moderately correlated (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.66). Both values were relatively high for most opioids, sedative psychotropics, and tricyclic antidepressants. Specific medicines with high values were phenobarbitone, oxycodone, morphine, clonazepam, nortriptyline, and propranolol; they were relatively low for risperidone and lithium. The proportions of opioids and hypnosedatives that had been recently dispensed to the deceased persons were smaller than for antidepressant, antipsychotic, and antiepileptic medicines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To reduce the risk of suicide, access to medicines of greater toxicity and lethality should be restricted, including by staged supply (regular supply of medicines in limited quantities), and limiting pack sizes; real\u2010time prescription monitoring could detect and minimise stockpiling.<\/jats:p><\/jats:sec>","DOI":"10.5694\/mja2.52638","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T03:35:50Z","timestamp":1742960150000},"page":"339-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The relative toxicity of medicines detected after poisoning suicide deaths in Australia, 2013\u201319: a data linkage case series study"],"prefix":"10.5694","volume":"222","author":[{"given":"Jessy","family":"Lim","sequence":"first","affiliation":[{"name":"The University of Sydney  Sydney NSW"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6326-4711","authenticated-orcid":false,"given":"Nicholas A","family":"Buckley","sequence":"additional","affiliation":[{"name":"The University of Sydney  Sydney NSW"},{"name":"New South Wales Poisons Information Centre the Children's Hospital at Westmead  Sydney NSW"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-8953","authenticated-orcid":false,"given":"Kate","family":"Chitty","sequence":"additional","affiliation":[{"name":"The University of Sydney  Sydney NSW"},{"name":"The University of Western Australia  Perth WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3701-4997","authenticated-orcid":false,"given":"Andrea L","family":"Schaffer","sequence":"additional","affiliation":[{"name":"The Bennett Institute of Applied Data Science University of Oxford  Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Schumann","sequence":"additional","affiliation":[{"name":"The Victorian Institute of Forensic Medicine Monash University  Melbourne VIC"},{"name":"Monash Addiction Research Centre Monash University  Melbourne VIC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zein","family":"Ali","sequence":"additional","affiliation":[{"name":"The University of Sydney  Sydney NSW"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Cairns","sequence":"additional","affiliation":[{"name":"The University of Sydney  Sydney NSW"},{"name":"New South Wales Poisons Information Centre the Children's Hospital at Westmead  Sydney NSW"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30030-X"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamahealthforum.2021.3042"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aap.2005.03.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2016.13.4.389"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/jamapsychiatry.2023.2289","article-title":"Substances detected during coroner postmortem toxicology analyses in poisoning\u2010 and nonpoisoning\u2010related suicides","volume":"80","author":"Lim JS","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2019.102609"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-019-00885-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-016-1358-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.0607"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.51985"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/13811118.2022.2072253"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-038181"},{"key":"e_1_2_9_15_1","unstructured":"Australian Department of Health and Aged Care.Australian statistics on medicines 2015. 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