{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:09:22Z","timestamp":1780636162728,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1103241"],"award-info":[{"award-number":["APP1103241"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2005174"],"award-info":[{"award-number":["APP2005174"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["MRF1150335"],"award-info":[{"award-number":["MRF1150335"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Journal of Australia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the epidemiology in Australia of catheter\u2010related infections in a national cohort of adults with kidney failure with incident haemodialysis central venous catheters (CVCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Cohort study nested within a cluster\u2010randomised trial (REDUcing the burden of dialysis Catheter Complications, REDUCCTION); analysis of prospectively collected trial data, linked with Australian and New Zealand Dialysis and Transplant (ANZDATA) registry and state hospitalisations data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Thirty\u2010four health services in Australia (excluding Western Australia) that provide chronic haemodialysis and participated in the REDUCCTION trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Adults (18 years or older) with chronic kidney failure who received incident haemodialysis CVCs during 20 December 2016 \u2013 31 March 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Hospitalisation with any haemodialysis CVC infection; haemodialysis CVC\u2010related bloodstream infections reported during the trial and verified by an independent panel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our analysis included 3943 adults with chronic kidney failure; their mean age was 60.4 years (standard deviation, 15.5\u00a0years); 1556 were women (39.5%) and 485 were Aboriginal or Torres Strait Islander people (12.3%). Catheter\u2010related infections were coded for 644 hospitalisations (24.5 per 100 patient\u2010years; 95% confidence interval [CI], 22.6\u201326.4 per 100 patient\u2010years); the incidence was higher among people under 55 years of age (adjusted incidence rate ratio [IRR], 1.55; 95% CI, 1.21\u20131.98) and those aged 55\u201370 years (adjusted IRR, 1.34; 95% CI, 1.05\u20131.70) than among people over 70 years of age. Community\u2010onset haemodialysis catheter\u2010related bloodstream infections were responsible for 159 hospitalisations (8.2% of 1938 infection\u2010related hospitalisations); 57 of 650 infection\u2010related hospitalisations of people under 55 years of age (8.8%), 62 of 640 of people aged 55\u201370 years (9.7%), and 40 of 648 of people over 70 years of age (6.2%). The median length of hospital stay with community\u2010onset haemodialysis CVC\u2010related bloodstream infections was ten days (interquartile range, 5\u201315 days), metastatic spread of infection was detected in twelve cases (7.5%), and four people died in hospital (2.5%); 40 removed haemodialysis CVCs did not require replacement. Nineteen of 121 hospitalisations for which the information was available included intensive care unit admissions (15.7%; median stay, 2.7 days; IQR, 1.1\u20134.6 days). The risk of haemodialysis CVC\u2010related <jats:italic>Staphylococcus aureus<\/jats:italic> bloodstream infection declined with age (relative risk ratio, 0.65 per decade; 95% CI, 0.47\u20130.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The health burden of haemodialysis CVC infections in Australia is substantial, particularly among adults under 70 years of\u00a0age.<\/jats:p><\/jats:sec>","DOI":"10.5694\/mja2.70014","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:21:38Z","timestamp":1753345298000},"page":"248-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The epidemiology of haemodialysis catheter infections in Australia, 2016\u201320: a prospective cohort study"],"prefix":"10.5694","volume":"223","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7936-025X","authenticated-orcid":false,"given":"Benjamin","family":"Lazarus","sequence":"first","affiliation":[{"name":"The George Institute for Global Health  Sydney NSW"},{"name":"Monash University  Melbourne VIC"},{"name":"Centre for Health Services Research the University of Queensland  Brisbane QLD"},{"name":"Monash Medical Centre  Melbourne VIC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevan R","family":"Polkinghorne","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne VIC"},{"name":"Monash Medical Centre  Melbourne VIC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P","family":"Gallagher","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Sydney 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