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The new guideline replaces the 2016 guideline, representing the first major update in nearly a decade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Recommendations<\/jats:title>\n                    <jats:p>\n                      The new guideline features critical new information, including: (1) new terminology and revised definition of myocardial infarction; (2) electrocardiogram (ECG) patterns of acute coronary occlusion myocardial infarction (ACOMI), beyond ST\u2010segment elevation; (3) use of clinical decision pathways incorporating high\u2010sensitivity cardiac troponin (hs\u2010cTn) assays for more efficient risk assessment; (4) stronger emphasis on the optimal timing of primary percutaneous coronary intervention in people with ST\u2010segment elevation myocardial infarction (STEMI); (5) use of intravascular imaging\u2010guided percutaneous coronary intervention in people with non\u2010ST\u2010segment elevation acute coronary syndromes (NSTEACS); (6) treatment guidance for specific groups, including those with cardiogenic shock, multivessel disease or spontaneous coronary artery dissection; (7) timing of platelet P2Y\n                      <jats:sub>12<\/jats:sub>\n                      inhibitor administration in STEMI and NSTEACS; (8) more detailed advice on post\u2010discharge care, including cardiac rehabilitation and secondary prevention programs, medicine adherence strategies, vaccinations and screening for mental health conditions; (9) treatment algorithms to enable more tailored prescribing of antiplatelet and anticoagulation therapies; (10) new recommended treatment target for low\u2010density lipoprotein cholesterol (LDL\u2010C); and (11) new recommendations on select medicines including PCSK9 inhibitors, \u03b2\u2010blockers and angiotensin receptor\u2010neprilysin inhibitors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Changes in Management as a Result of the Guideline<\/jats:title>\n                    <jats:p>\n                      The new guideline introduces key practice changes including broader recognition of ECG patterns of ACOMI, integration of hs\u2010cTn testing into clinical decisions pathways and selective use of intravascular imaging in NSTEACS. Updated P2Y\n                      <jats:sub>12<\/jats:sub>\n                      inhibitor timing, stricter LDL\u2010C targets and PCSK9 inhibitor use support more tailored and evidence\u2010based care in the secondary prevention of ACS. The full guideline is available at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.heartfoundation.org.au\/for-professionals\/acs-guideline\">www.heartfoundation.org.au\/for\u2010professionals\/acs\u2010guideline<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.5694\/mja2.70127","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:26:37Z","timestamp":1771233997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian Clinical Guideline for Diagnosing and Managing Acute Coronary Syndromes 2025"],"prefix":"10.5694","volume":"224","author":[{"given":"David B.","family":"Brieger","sequence":"first","affiliation":[{"name":"Concord Repatriation General Hospital 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