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He received intravenous artesunate followed by artemether\u2013lumefantrine. However, parasite clearance was delayed, and despite a negative blood film following treatment, the patient was readmitted 3\u2009weeks later with recurrent parasitaemia. Further testing for drug\u2010resistant phenotypes and genotypes demonstrated reduced susceptibility to lumefantrine, an A675V mutation in the\n                    <jats:italic>pfk13<\/jats:italic>\n                    gene and increased ring\u2010stage survival, consistent with partial artemisinin resistance. The case highlights the high risk of\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    treatment failure in patients with hyperparasitaemia and partial drug resistance.\n                  <\/jats:p>","DOI":"10.5694\/mja2.70136","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T05:23:37Z","timestamp":1768800217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Treatment Failure and Post\u2010Artesunate Delayed Haemolysis in a Returned Traveller From Uganda With Partially Drug\u2010Resistant Severe\n                    <i>Plasmodium falciparum<\/i>\n                    Malaria"],"prefix":"10.5694","volume":"224","author":[{"given":"Jye","family":"Travis","sequence":"first","affiliation":[{"name":"QIMR Berghofer  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-9659","authenticated-orcid":false,"given":"Kate","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chapman","sequence":"additional","affiliation":[{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Huang","sequence":"additional","affiliation":[{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Tan","sequence":"additional","affiliation":[{"name":"QIMR Berghofer  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Cheng","sequence":"additional","affiliation":[{"name":"QIMR Berghofer  Brisbane Queensland Australia"},{"name":"Australian Defence Force Malaria and Infectious Disease Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-7960","authenticated-orcid":false,"given":"Bridget E.","family":"Barber","sequence":"additional","affiliation":[{"name":"QIMR Berghofer  Brisbane Queensland Australia"},{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-555953"},{"key":"e_1_2_9_3_1","unstructured":"Infectious Diseases Data Observatory (IDDO) \u201cParasite Clearance Estimator (PCE). Infectious Diseases Data Observatory (Software) \u201d2011 https:\/\/www.iddo.org\/wwarn\/parasite\u2010clearance\u2010estimator\u2010pce."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00276-21"},{"key":"e_1_2_9_5_1","unstructured":"World Health Organization \u201cMalaria: Artemisinin Partial Resistance 2025 \u201dhttps:\/\/www.who.int\/news\u2010room\/questions\u2010and\u2010answers\/item\/artemisinin\u2010resistance."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2471\/B09146"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211803"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33873-x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-253"},{"key":"e_1_2_9_10_1","volume-title":"Therapeutic Guidelines: Antibiotic. eTG Complete","author":"Therapeutic Guidelines Ltd","year":"2024"}],"container-title":["Medical Journal of Australia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.5694\/mja2.70136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.5694\/mja2.70136","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.5694\/mja2.70136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:14:01Z","timestamp":1769746441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.5694\/mja2.70136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.5694\/mja2.70136"],"URL":"https:\/\/doi.org\/10.5694\/mja2.70136","archive":["Portico"],"relation":{},"ISSN":["0025-729X","1326-5377"],"issn-type":[{"value":"0025-729X","type":"print"},{"value":"1326-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70136"}}