{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:57:52Z","timestamp":1789516672545,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009287","name":"NSW Health","doi-asserted-by":"publisher","award":["341925612"],"award-info":[{"award-number":["341925612"]}],"id":[{"id":"10.13039\/501100009287","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Journal of Australia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n To analyse longitudinal change in motor neuron disease (MND) mortality in Australia from 1986 to 2023.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Australian population\u2010based study of MND mortality.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n All MND mortality and Australian population data from 1 January 1986 to 31 December 2023 were obtained from the Australian Bureau of Statistics.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n MND mortality records were analysed, and certified deaths were summarised by year of registration. MND mortality rates, 95% confidence intervals (CIs) and Joinpoint regression trends were calculated. Data were further subset by demographic and geographical categories to report Australian MND mortality by age group, sex, state\/territory location and remoteness areas classification.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In Australia, the total number of\n MND<\/jats:styled-content>\n deaths more than tripled over the past 37\u2009years, from 238 in 1986 to 781 in 2023. The unadjusted mortality rate in 1986 was 1.49 (95%\n CI<\/jats:styled-content>\n , 1.30\u20131.69) per 100,000 population and increased to 2.93 (95%\n CI<\/jats:styled-content>\n , 2.73\u20133.14) per 100,000 population by 2023. After age standardisation, the annual percentage change across 1986\u20132023 was determined to be 0.47% (95% confidence limit, 0.16\u20130.86). Joinpoint modelling suggests a more recent reduction in adjusted mortality rates. In 2023,\n MND<\/jats:styled-content>\n accounted for 0.43% of all\u2010cause deaths in Australia, increasing from 0.21% in 1986. The number of\n MND<\/jats:styled-content>\n deaths in Australia peaked at age 70\u201379\u2009years.\n MND<\/jats:styled-content>\n mortality was higher among men than women (rate ratio, 1.41; 95%\n CI<\/jats:styled-content>\n , 1.33\u20131.51).\n MND<\/jats:styled-content>\n mortality rates were similar among New South Wales, Victoria and Queensland (2.93, 3.08 and 2.85 per 100,000 population, respectively), with higher rates in South Australia and Tasmania (3.44 and 4.12 per 100,000 population, respectively).\n MND<\/jats:styled-content>\n mortality rates were higher in inner and outer regional areas (3.90 and 3.24 per 100,000 population, respectively) compared with major cities (2.79 per 100,000 population).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Adjusted MND mortality rates in Australia increased over 37\u2009years.<\/jats:p>\n <\/jats:sec>","DOI":"10.5694\/mja2.70168","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:53:44Z","timestamp":1774342424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Motor Neuron Disease Mortality Trends in Australia From 1986 to 2023: A Population\u2010Based Study"],"prefix":"10.5694","volume":"224","author":[{"given":"Carol M. Y.","family":"Lee","sequence":"first","affiliation":[{"name":"Motor Neuron Disease Research Centre Macquarie University Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-0735","authenticated-orcid":false,"given":"Rupendra N.","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Centre for Economic Impacts of Genomic Medicine Macquarie University Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Gold","sequence":"additional","affiliation":[{"name":"Albion Street Centre Sydney New South Wales Australia"},{"name":"University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Stevenson","sequence":"additional","affiliation":[{"name":"University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6319-9473","authenticated-orcid":false,"given":"Kelly L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Motor Neuron Disease Research Centre Macquarie University Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndal","family":"Henden","sequence":"additional","affiliation":[{"name":"Motor Neuron Disease Research Centre Macquarie University Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6304-0283","authenticated-orcid":false,"given":"Sandrine K. K.","family":"Chan Moi Fat","sequence":"additional","affiliation":[{"name":"Motor Neuron Disease Research Centre Macquarie University Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2480-7072","authenticated-orcid":false,"given":"Zoe","family":"Zussa","sequence":"additional","affiliation":[{"name":"Motor Neuron Disease Research Centre Macquarie University Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Wright","sequence":"additional","affiliation":[{"name":"Charles Sturt University Orange New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jude","sequence":"additional","affiliation":[{"name":"Rural Clinical School UNSW Sydney Wagga Wagga New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7937-7844","authenticated-orcid":false,"given":"Mark A. 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