{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:16:39Z","timestamp":1790381799755,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1172873"],"award-info":[{"award-number":["GNT1172873"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1172900"],"award-info":[{"award-number":["GNT1172900"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1173361"],"award-info":[{"award-number":["GNT1173361"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2033078"],"award-info":[{"award-number":["GNT2033078"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2033299"],"award-info":[{"award-number":["GNT2033299"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Journal of Australia"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the awareness, usage and perceptions of doxycycline post\u2010exposure prophylaxis (doxyPEP) for sexually transmitted infection (STI) prevention among gay and bisexual men and transgender (trans) and gender diverse people in Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional online survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting, Participants<\/jats:title>\n                    <jats:p>National multi\u2010site survey in Australia from 1 July 2024 to 30 November 2024, recruiting from 13 sexual health and community clinics, 6 general practices, social media, dating applications, and university portals. Gay and bisexual men and trans and gender diverse people aged \u2265\u200918\u2009years living in Australia were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>DoxyPEP awareness, ever use, recent use (past 12\u2009months), dosage regimens, sourcing methods and planned future use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2095 participants, half (1080\/2095, 51.6%) had heard of doxyPEP. Of those aware, 323\/1080 (29.9%) had ever used doxyPEP, and 306\/1080 (28.3%) were recent users. DoxyPEP awareness and usage varied by HIV status and pre\u2010exposure prophylaxis (PrEP) use (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Nearly two\u2010thirds of users had taken the recommended 200\u2009mg within 72\u2009h after sex (205\/323, 63.5%). Among recent users, 29\/306 (9.5%) reported recent syphilis diagnoses, and 85\/306 (27.8%) had \u2265\u20092 STI diagnoses in the past 12\u2009months. Of those who had ever used doxyPEP, 135\/323 (41.8%) obtained prescriptions from clinicians, 17\/323 (5.3%) obtained it online, and 28\/323 (8.7%) purchased it in person overseas without a prescription. Of those aware of doxyPEP, 490\/1080 (45.4%) planned to use doxyPEP in the next 12\u2009months, primarily to prevent chlamydia (460\/490, 93.9%), gonorrhoea (422\/490, 86.1%) or syphilis (386\/490, 78.8%). Some intended to prevent\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Mycoplasma genitalium<\/jats:italic>\n                      <\/jats:styled-content>\n                      (92\/490, 18.8%) or mpox (36\/490, 7.4%). Among non\u2010users, 306\/756 (40.5%) worried about antibiotic resistance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DoxyPEP use was happening quickly but often involved non\u2010recommended regimens and unsupervised sourcing. Urgent educational interventions and improved clinical access are needed for safe implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5694\/mja2.70180","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:23:57Z","timestamp":1776162237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Awareness, Usage and Perceptions of Doxycycline Post\u2010Exposure Prophylaxis (doxyPEP) for Prevention of Sexually Transmitted Infections in Australia: Insights From a National Cross\u2010Sectional Survey"],"prefix":"10.5694","volume":"224","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-5731","authenticated-orcid":false,"given":"Phyu Mon","family":"Latt","sequence":"first","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre, Bayside Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-3233","authenticated-orcid":false,"given":"Ei T.","family":"Aung","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre, Bayside Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Maddaford","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre, Bayside Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai J.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Fairley","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre, Bayside Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Canberra Sexual Health Centre, Canberra Health Services  Canberra Australian Capital Territory Australia"},{"name":"Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Khaw","sequence":"additional","affiliation":[{"name":"Adelaide Sexual Health Centre, Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Adelaide University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Varma","sequence":"additional","affiliation":[{"name":"Sydney Sexual Health Centre, South Eastern Sydney Local Health District  Sydney New South Wales Australia"},{"name":"Kirby Institute UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Thng","sequence":"additional","affiliation":[{"name":"Sexual Health Services, Gold Coast Health  Gold Coast Queensland Australia"},{"name":"Institute for Biomedicine and Glycomics Griffith University  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoji","family":"Gunathilake","sequence":"additional","affiliation":[{"name":"Kirby Institute UNSW Sydney  Sydney New South Wales Australia"},{"name":"Centre for Disease Control, Northern Territory Department of Health  Darwin Northern Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-9677","authenticated-orcid":false,"given":"Vincent J.","family":"Cornelisse","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Kirby Institute UNSW Sydney  Sydney New South Wales Australia"},{"name":"Mid North Coast Local Health District  Port Macquarie New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teralynn","family":"Ludwick","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan T.","family":"Cardwell","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Traeger","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Burnet Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona S.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre, Bayside Health  Melbourne Victoria Australia"},{"name":"Centre for Epidemiology and Biostatistics University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dash","family":"Heath\u2010Paynter","sequence":"additional","affiliation":[{"name":"Kirby Institute UNSW Sydney  Sydney New South Wales Australia"},{"name":"Health Equity Matters  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Riley","sequence":"additional","affiliation":[{"name":"Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Grace","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9349-3080","authenticated-orcid":false,"given":"Fabian Y. S.","family":"Kong","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-0657","authenticated-orcid":false,"given":"Eric P. F.","family":"Chow","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Melbourne Sexual Health Centre, Bayside Health  Melbourne Victoria Australia"},{"name":"Centre for Epidemiology and Biostatistics University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the DoxyAWARE Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Global Progress Report on HIV, Viral Hepatitis and Sexually Transmitted Infections, 2021: Accountability for the Global Health Sector Strategies 2016\u20132021: Actions for Impact","author":"World Health Organization","year":"2021"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00112-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.107186"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52258"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2024-056208"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304007"},{"key":"e_1_2_12_8_1","unstructured":"S.Abe D.Shiojiri A.Kawashima et\u00a0al. \u201cOAC0803: Doxycycline PrEP Prevents STIs Without Affecting Vaginal Bacterial Flora in Female Sex Workers \u201din25th International AIDS Conference; 2024 Jul 22\u201326; Munich Germany https:\/\/www.natap.org\/2024\/IAS\/IAS_26.htm."},{"key":"e_1_2_12_9_1","first-page":"1","article-title":"CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States, 2024","volume":"73","author":"Bachmann L. H.","year":"2024","journal-title":"Morbidity and Mortality Weekly Report. Recommendations and Reports"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/09564624251352053"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30210-8"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000002079"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30186-9"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2024-056152"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2019-054325"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000002061"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52255"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad129"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae176"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2024-056240"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/09564624241308026"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-06737-1"},{"key":"e_1_2_12_24_1","unstructured":"K. J.Jonas \u201cS021: \u2018It Is More Than STI Prevention!\u2019: Intention to Use and Procurement of Doxycycline Prophylaxis \u201dinIUSTI Europe Conference 2023 Oct 27; Malta accessed July 2025 https:\/\/www.iusti\u2010europe.eu\/web\/images\/docs\/Abstractbook_Malta2023.pdf."},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2196\/72491"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199906000-00004"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00356-0"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlaf120"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.33321\/cdi.2023.47.45"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52343-0"},{"key":"e_1_2_12_31_1","volume-title":"Sexually Transmitted Disease Surveillance 2018","author":"Centers for Disease Control and Prevention","year":"2019"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2196\/45695"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH24136"}],"updated-by":[{"DOI":"10.5694\/mja2.70198","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000}}],"container-title":["Medical Journal of Australia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.5694\/mja2.70180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.5694\/mja2.70180","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.5694\/mja2.70180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:07:27Z","timestamp":1777284447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.5694\/mja2.70180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.5694\/mja2.70180"],"URL":"https:\/\/doi.org\/10.5694\/mja2.70180","archive":["Portico"],"relation":{},"ISSN":["0025-729X","1326-5377"],"issn-type":[{"value":"0025-729X","type":"print"},{"value":"1326-5377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70180"}}