{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:51:04Z","timestamp":1776401464597,"version":"3.51.2"},"reference-count":29,"publisher":"The Mass Spectrometry Society of Japan","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mass Spectrometry"],"published-print":{"date-parts":[[2022,12,20]]},"DOI":"10.5702\/massspectrometry.a0105","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T22:21:30Z","timestamp":1666822890000},"page":"A0105-A0105","source":"Crossref","is-referenced-by-count":6,"title":["Matrix-Assisted Laser Desorption\/Ionization (MALDI) Mass Spectrometry Imaging of L-4-Phenylalanineboronic Acid (BPA) in a Brain Tumor Model Rat for Boron Neutron Capture Therapy (BNCT)"],"prefix":"10.5702","volume":"11","author":[{"given":"Yumi","family":"Miyake","sequence":"first","affiliation":[{"name":"Forefront Research Center, Graduate School of Science, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachie","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Murata","sequence":"additional","affiliation":[{"name":"Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michisato","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Forefront Research Center, Graduate School of Science, Osaka University"},{"name":"MS open innovation project in JEOL YOKOGUSHI Research Alliance Laboratories, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3680","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) W. Sauerwein, A. Wittig, R. Moss, Y. Nakagawa. Neutron Capture Therapy, Springer Berlin, Heidelberg, 2012.","DOI":"10.1007\/978-3-642-31334-9"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2) H. Nakamura. Boron neutron capture therapy historical development and current status of boron delivery agents for boron neutron capture therapy. <i>Radioisotopes<\/i> 64: 47\u201358, 2015. doi: 10.3769\/radioisotopes.64.47","DOI":"10.3769\/radioisotopes.64.47"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3) S. Kusaka, Y. Morizane, Y. Tokumaru, S. Tamaki, I. R. Maemunah, Y. Akiyama, F. Sato, I. Murata. Boron delivery to brain cells <i>via<\/i> cerebrospinal fluid (CSF) circulation for BNCT in rat melanoma model. <i>Biology<\/i> (Basel) 11: 397, 2022. doi: 10.3390\/biology11030397","DOI":"10.3390\/biology11030397"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4) T. Tsurubuchi, M. Shirakawa, W. Kurosawa, K. Matsumoto, R. Ubagai, H. Umishio, Y. Suga, J. Yamazaki, A. Arakawa, Y. Maruyama, T. Seki, Y. Shibui, F. Yoshida, A. Zaboronok, M. Suzuki, Y. Sakurai, H. Tanaka, K. Nakai, E. Ishikawa, A. Matsumura. Evaluation of a novel boron-containing \u03b1-D-mannopyranoside for BNCT. <i>Cells<\/i> 9: 1277, 2020. doi: 10.3390\/cells9051277","DOI":"10.3390\/cells9051277"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5) O. Reifschneider, C. L. Sch\u00fctz, C. Brochhausen, G. Hampel, T. Ross, M. Sperling, U. Karst. Quantitative bioimaging of <i>p<\/i>-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy. <i>Anal. Bioanal. Chem.<\/i> 407: 2365\u20132371, 2015. doi: 10.1007\/s00216-014-8012-4","DOI":"10.1007\/s00216-014-8012-4"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6) S. Chandra, T. Ahmad, R. F. Barth, G. W. Kabalka. Quantitative evaluation of boron neutron capture therapy (BNCT) drugs for boron delivery and retention at subcellular-scale resolution in human glioblastoma cells with imaging secondary ion mass spectrometry (SIMS). <i>J. Microsc.<\/i> 254: 146\u2013156, 2014. doi: 10.1111\/jmi.12126","DOI":"10.1111\/jmi.12126"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7) S. Aldossari, G. McMahon, N. P. Lockyer, K. L. Moore. Microdistribution and quantification of the boron neutron capture therapy drug BPA in primary cell cultures of human glioblastoma tumour by NanoSIMS. <i>Analyst<\/i> (Lond.) 144: 6214\u20136224, 2019. doi: 10.1039\/c9an01336a","DOI":"10.1039\/C9AN01336A"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8) Y. Sugiura, K. Honda, M. Suematsu. Development of an imaging mass spectrometry technique for visualizing localized cellular signaling mediators in tissues. <i>Mass Spectrom.<\/i> (Tokyo) 4: A0040, 2015. doi: 10.5702\/massspectrometry.A0040","DOI":"10.5702\/massspectrometry.A0040"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9) D. S. Cornett, M. L. Reyzer, P. Chaurand, R. M. Caprioli. MALDI imaging mass spectrometry: Molecular snapshots of biochemical systems. <i>Nat. Methods<\/i> 4: 828\u2013833, 2007. doi: 10.1038\/nmeth1094","DOI":"10.1038\/nmeth1094"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10) M. R. Groseclose, M. Andersson, W. M. Hardesty, R. M. Caprioli. Identification of proteins directly from tissue: <i>in situ<\/i> tryptic digestions coupled with imaging mass spectrometry. <i>J. Mass Spectrom.<\/i> 42: 254\u2013262, 2007. doi: 10.1002\/jms.1177","DOI":"10.1002\/jms.1177"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11) P. M. Angel, K. Norris-Caneda, R. R. Drake. <i>In situ<\/i> imaging of tryptic peptides by MALDI imaging mass spectrometry using fresh-frozen or formalin-fixed, paraffin-embedded tissue. <i>Curr. Protoc. Protein Sci.<\/i> 94: e65, 2018. doi: 10.1002\/cpps.65","DOI":"10.1002\/cpps.65"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12) S. Shimma, Y. Sugiura, T. Hayasaka, Y. Hoshikawa, T. Noda, M. Setou. MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis. <i>J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i> 855: 98\u2013103, 2007. doi: 10.1016\/j.jchromb.2007.02.037","DOI":"10.1016\/j.jchromb.2007.02.037"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13) N. V. Gogichaeva, T. Williams, M. A. Alterman. MALDI TOF\/TOF tandem mass spectrometry as a new tool for amino acid analysis. <i>J. Am. Soc. Mass Spectrom.<\/i> 18: 279\u2013284, 2007. doi: 10.1016\/j.jasms.2006.09.013","DOI":"10.1016\/j.jasms.2006.09.013"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14) Q. Wu, T. J. Comi, B. Li, S. S. Rubakhin, J. V. Sweedler. On-tissue derivatization <i>via<\/i> electrospray deposition for matrix-assisted laser desorption\/ionization mass spectrometry imaging of endogenous fatty acids in rat brain tissues. <i>Anal. Chem.<\/i> 88: 5988\u20135995, 2016. doi: 10.1021\/acs.analchem.6b01021","DOI":"10.1021\/acs.analchem.6b01021"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) R. J. A. Goodwin, M. Shariatgorji, P. E. Andren. MALDI mass spectrometry imaging of dopamine and PET D1 and D2 receptor ligands in rodent brain tissues. in Dopamine Receptor Technologies, Neuromethods, Springer Science+Business Media, New York, 2015, Chap. 10, p. 177.","DOI":"10.1007\/978-1-4939-2196-6_10"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) M. Shariatgorji, A. Nilsson, R. J. A. Goodwin, P. Kallback, N. Schintu, X. Zhang, A. R. Crossman, E. Bezard, P. Svenningsson, P. E. Andren. Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections. <i>Neuron<\/i> 84: 697\u2013707, 2014. doi: 10.1016\/j.neuron.2014.10.011","DOI":"10.1016\/j.neuron.2014.10.011"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17) E. Takeo, Y. Sugiura, T. Uemura, K. Nishimoto, M. Yasuda, E. Sugiyama, S. Ohtsuki, T. Higashi, T. Nishikawa, M. Suematsu, E. Fukusaki, S. Shimma. Tandem mass spectrometry imaging reveals distinct accumulation patterns of steroid structural isomers in human adrenal glands. <i>Anal. Chem.<\/i> 91: 8918\u20138925, 2019. doi: 10.1002\/sia.6537","DOI":"10.1002\/sia.6537"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) S. Castellino, N. M. Lareau, M. R. Groseclose. The emergence of imaging mass spectrometry in drug discovery and development: Making a difference by driving decision making. <i>J. Mass Spectrom.<\/i> 56: e4717, 2021. doi: 10.1002\/jms.4717","DOI":"10.1002\/jms.4563"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19) J. R. Granborg, A. M. Handler, C. Janfelt. Mass spectrometry imaging in drug distribution and drug metabolism studies\u2014Principles, applications and perspectives. <i>Trends Analyt. Chem.<\/i> 146: 116482, 2022. doi: 10.1016\/j.trac.2021.116482","DOI":"10.1016\/j.trac.2021.116482"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) E. Claude, E. A. Jones, S. D. Pringle. DESI mass spectrometry imaging (MSI). in Imaging Mass Spectrometry: Methods and Protocols, Methods in Molecular Biology, Humana, New York, 2017, vol. 1618, Chap. 7, p. 65. doi: 10.1007\/978-1-4939-7051-3_7","DOI":"10.1007\/978-1-4939-7051-3_7"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21) Y. Otsuka, B. Kamihoriuchi, A. Takeuchi, F. Iwata, S. Tortorella, T. Matsumoto. High-spatial-resolution multimodal imaging by tapping-mode scanning probe electrospray ionization with feedback control. <i>Anal. Chem.<\/i> 93: 2263\u20132272, 2021. doi: 10.1021\/acs.analchem.0c04144","DOI":"10.1021\/acs.analchem.0c04144"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) S. V. Nuffel, A. Brunelle. TOF-SIMS imaging of biological tissue sections and structural determination using tandem MS. in Mass Spectrometry Imaging of Small Molecules: Methods and Protocols, Methods in Molecular Biology, Humana, New York, 2022, vol. 2437, Chap. 7, p. 77. doi: 10.1007\/978-1-0716-2030-4_5","DOI":"10.1007\/978-1-0716-2030-4_5"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23) M. Oya, H. Suzuki, A. R. J. Anas, K. Oishi, K. Ono, S. Yamaguchi, M. Eguchi, M. Sawada. LC-MS\/MS imaging with thermal film-based laser microdissection. <i>Anal. Bioanal. Chem.<\/i> 410: 491\u2013499, 2018. doi: 10.1007\/s00216-017-0739-2","DOI":"10.1007\/s00216-017-0739-2"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24) Y. Sugiura, S. Shimma. Imaging mass spectrometry for metabolomics. <i>J. Mass Spectrom. Soc. Jpn.<\/i> 65: 215\u2013219, 2017. doi: 10.5702\/massspec.S17-51","DOI":"10.5702\/massspec.S17-51"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) A. Chacon, I. Zagol-Ikapitte, V. Amarnath, M. L. Reyzer, J. A. Oates, R. M. Caprioli, O. Boutaud. On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry. <i>J. Mass Spectrom.<\/i> 46: 840\u2013846, 2011. doi: 10.1002\/jms.1958","DOI":"10.1002\/jms.1958"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26) S. Toue. MALDI-IMS assisted by on-tissue chemical derivatization for visualizing amino acid distribution in a single tissue slice. <i>J. Mass Spectrom. Soc. Jpn.<\/i> 63: 145\u2013147, 2015. doi: 10.5702\/massspec.S15-27","DOI":"10.5702\/massspec.S15-27"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27) T. Satoh, A. Kubo, S. Shimma, M. Toyoda. Mass spectrometry imaging and structural analysis of lipids directly on tissue specimens by using a spiral orbit type tandem time-of-flight mass spectrometer, SpiralTOF-TOF. <i>Mass Spectrom.<\/i> (Tokyo) 1: A0013, 2012. doi: 10.5702\/massspectrometry.A0013","DOI":"10.5702\/massspectrometry.A0013"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28) M. Janda, B. K. B. Seah, D. Jakob, J. Beckmann, B. Geier, M. Liebeke. Determination of abundant metabolite matrix adducts illuminates the dark metabolome of MALDI-mass spectrometry imaging datasets. <i>Anal. Chem.<\/i> 93: 8399\u20138407, 2021. doi: 10.1021\/acs.analchem.0c04720","DOI":"10.1021\/acs.analchem.0c04720"},{"key":"29","doi-asserted-by":"publisher","unstructured":"17) E. Takeo, Y. Sugiura, T. Uemura, K. Nishimoto, M. Yasuda, E. Sugiyama, S. Ohtsuki, T. Higashi, T. Nishikawa, M. Suematsu, E. Fukusaki, S. Shimma. Tandem mass spectrometry imaging reveals distinct accumulation patterns of steroid structural isomers in human adrenal glands. <i>Anal. Chem.<\/i> 91: 8918\u20138925, 2019. doi: 10.1002\/sia.6537","DOI":"10.1002\/sia.6537"}],"container-title":["Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/massspectrometry\/11\/1\/11_A0105\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T05:10:59Z","timestamp":1715317859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/massspectrometry\/11\/1\/11_A0105\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.5702\/massspectrometry.a0105","relation":{"references":[{"id-type":"doi","id":"10.50893\/data.massspectrometry.21523023","asserted-by":"subject"},{"id-type":"doi","id":"10.50893\/data.massspectrometry.21521988","asserted-by":"subject"},{"id-type":"doi","id":"10.50893\/data.massspectrometry.21522303","asserted-by":"subject"}]},"ISSN":["2186-5116","2187-137X"],"issn-type":[{"value":"2186-5116","type":"electronic"},{"value":"2187-137X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"article-number":"A0105"}}