{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:16:42Z","timestamp":1784891802553,"version":"3.55.0"},"reference-count":26,"publisher":"The Mass Spectrometry Society of Japan","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mass Spectrometry"],"published-print":{"date-parts":[[2023,5,24]]},"DOI":"10.5702\/massspectrometry.a0122","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T22:12:21Z","timestamp":1683065541000},"page":"A0122-A0122","source":"Crossref","is-referenced-by-count":1,"title":["Immuno-Mass Spectrometry Workflow for Quantification of Serum \u03b1-Fetoprotein Using Antibody-Immobilized Magnetic Beads and Modified Eluents"],"prefix":"10.5702","volume":"12","author":[{"given":"Yoshio","family":"Takahata","sequence":"first","affiliation":[{"name":"Biomolecule Analysis Group, Medical ProteoScope Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misato","family":"Hara","sequence":"additional","affiliation":[{"name":"Tamagawa Seiki Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouhei","family":"Nishino","sequence":"additional","affiliation":[{"name":"Biomolecule Analysis Group, Medical ProteoScope Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Biomolecule Analysis Group, Medical ProteoScope Co., Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3680","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) E. Ciccimaro, I. A. Blair. Stable-isotope dilution LC-MS for quantitative biomarker analysis. <i>Bioanalysis<\/i> 2: 311\u2013341, 2010.","DOI":"10.4155\/bio.09.185"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) A. Vald\u00e9s, M. Lewitt, E. Wiss, M. Ramstr\u00f6m, E. M. Strage. Development of a parallel reaction monitoring-MS method to quantify IGF proteins in dogs and a case of nonislet cell tumor hypoglycemia. <i>J. Proteome Res.<\/i> 18: 18\u201329, 2019.","DOI":"10.1021\/acs.jproteome.8b00259"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Z. Huang, X. D. Pan. Identification and quantification of immunoglobulin G (G1, G2, G3 and G4) in human blood plasma by high-resolution quadrupole-Orbitrap mass spectrometry. <i>RSC Advances<\/i> 7: 20212\u201320218, 2017.","DOI":"10.1039\/C7RA02623D"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) B. Winther, M. Nordlund, E. Paus, L. Reubsaet, T. G. Halvorsen. Immunocapture as ultimate sample cleanup in LC-MS\/MS determination of the early stage biomarker ProGRP. <i>J. Sep. Sci.<\/i> 32: 2937\u20132943, 2019.","DOI":"10.1002\/jssc.200900233"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) S. B. Torsetnes, M. S. Nordlund, E. Paus, T. G. Halvorsen, L. Reubsaet. Digging deeper into the field of the small cell lung cancer tumor marker ProGRP: A method for differentiation of its isoforms. <i>J. Proteome Res.<\/i> 12: 412\u2013420, 2013.","DOI":"10.1021\/pr300751j"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) T. McAvoy, M. E. Lassman, D. S. Spellman, Z. Ke, B. J. Howell, O. Wong, L. Zhu, M. Tanen, A. Struyk, O. F. Laterza. Quantification of tau in cerebrospinal fluid by immunoaffinity enrichment and tandem mass spectrometry. <i>Clin. Chem.<\/i> 60: 683\u2013689, 2014.","DOI":"10.1373\/clinchem.2013.216515"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) A. Y. Lee, D. L. Chappell, M. J. Bak, M. Judo, L. Liang, T. Churakova, G. Ayanoglu, J. Castro-Perez, H. Zhou, S. Previs, S. C. Souza, M. E. Lassman, O. F. Laterza. Multiplexed quantification of proglucagon-derived peptides by immunoaffinity enrichment and tandem mass spectrometry after a meal tolerance test. <i>Clin. Chem.<\/i> 62: 227\u2013235, 2016.","DOI":"10.1373\/clinchem.2015.244251"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) H. Zhang, H. Gu, P. Shipkova, E. Ciccimaro, H. Sun, Q. Zhao, T. V. Olah. Immunoaffinity LC-MS\/MS for quantitative determination of a free and total protein target as a target engagement biomarker. <i>Bioanalysis<\/i> 9: 1573\u20131588, 2017.","DOI":"10.4155\/bio-2017-0152"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) H. Lund, K. L\u00f8vsletten, E. Paus, T. G. Halvorsen, L. Reubsaet. Immuno-MS based targeted proteomics: Highly specific, sensitive, and reproducible human chorionic gonadotropin determination for clinical diagnostics and doping analysis. <i>Anal. Chem.<\/i> 84: 7926\u20137932, 2012.","DOI":"10.1021\/ac301418f"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) M. C. S. Levern\u00e6s, M. N. Broughton, L. Reubsaet, T. G. Halvorsen. To elute or not to elute in immunocapture bottom-up LC-MS. <i>J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.<\/i> 1055\u20131056: 51\u201360, 2017.","DOI":"10.1016\/j.jchromb.2017.03.044"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Y. Liu, K. Sogawa, M. Sunaga, H. Umemura, M. Satoh, T. Kazami, M. Yoshikawa, T. Tomonaga, O. Yokosuka, F. Nomura. Increased concentrations of Apo A-I and Apo A-II fragments in the serum of patients with hepatocellular carcinoma by magnetic beads-assisted MALDI-TOF mass spectrometry. <i>Am. J. Clin. Pathol.<\/i> 141: 52\u201361, 2014.","DOI":"10.1309\/AJCPBLFBNAP6N2UN"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) P. Liu, X. Fang, H. Cao, M. Gu, J. Kong, A. Deng. Magnetic-bioluminescent-nanoliposomes for ultrasensitive and portable detection of protein biomarkers in blood. <i>Anal. Chim. Acta<\/i> 1039: 98\u2013107, 2018.","DOI":"10.1016\/j.aca.2018.07.039"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Y. Xia, Q. Li, L. Gong, H. Xu, L. Pang, Z. Li, J. Si. Detection of hepatocellular carcinoma biomarker Golgi Protein 73 based on magnetic enzyme-linked immunoassay. <i>J. Nanosci. Nanotechnol.<\/i> 17: 231\u2013237, 2017.","DOI":"10.1166\/jnn.2017.12456"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Y. Jeon, Y. S. Choi, E. S. Jang, J. W. Kim, S. H. Jeong. Persistent \u03b1-fetoprotein elevation in healthy adults and mutational analysis of \u03b1-fetoprotein promoter, enhancer, and silencer regions. <i>Gut Liver<\/i> 11: 136\u2013141, 2017.","DOI":"10.5009\/gnl16069"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) B. Dahiya, P. K. Mehta. Detection of potential biomarkers associated with outrageous diseases and environmental pollutants by nanoparticle-based immuno-PCR assays. <i>Anal. Biochem.<\/i> 587: 113444, 2019.","DOI":"10.1016\/j.ab.2019.113444"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) L. Ion, B. A. Petre. in Advancements of Mass Spectrometry in Biomedical Research. Advances in Experimental Medicine and Biology, Vol. 1140 (Ed: A. Woods, C. Darie), Springer, Cham, 2019, pp. 377\u2013388.","DOI":"10.1007\/978-3-030-15950-4_21"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) H. Neubert, C. M. Shuford, T. V. Olah, F. Garofolo, G. A. Schultz, B. R. Jones, L. Amaravadi, O. F. Laterza, K. Xu, B. L. Ackermann. Protein biomarker quantification by immunoaffinity liquid chromatography-tandem mass spectrometry: Current state and future vision. <i>Clin. Chem.<\/i> 66: 282\u2013301, 2020.","DOI":"10.1093\/clinchem\/hvz022"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) H. Neubert, D. Muirhead, M. Kabir, C. Grace, A. Cleton, R. Arends. Sequential protein and peptide immunoaffinity capture for mass spectrometry-based quantification of total human \u03b2-nerve growth factor. <i>Anal. Chem.<\/i> 85: 1719\u20131726, 2013.","DOI":"10.1021\/ac303031q"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) L. Callipo, G. Caruso, P. Foglia, R. Gubbiotti, R. Samperi, A. Lagan\u00e0. Immunoprecipitation on magnetic beads and liquid chromatography-tandem mass spectrometry for carbonic anhydrase II quantification in human serum. <i>Anal. Biochem.<\/i> 400: 195\u2013202, 2010.","DOI":"10.1016\/j.ab.2010.01.039"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) J. Palandra, A. Finelli, M. Zhu, J. Masferrer, H. Neubert. Highly specific and sensitive measurements of human and monkey interleukin 21 using sequential protein and tryptic peptide immunoaffinity LC-MS\/MS. <i>Anal. Chem.<\/i> 85: 5522\u20135529, 2013.","DOI":"10.1021\/ac4006765"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) M. Omata, L. A. Lesmana, R. Tateishi, P. J. Chen, S. M. Lin, H. Yoshida, M. Kudo, J. M. Lee, B. I. Choi, R. T. P. Poon, S. Shiina, A. L. Cheng, J. D. Jia, S. Obi, K. H. Han, W. Jafri, P. Chow, S. G. Lim, Y. K. Chawla, U. Budihusodo, R. A. Gani, C. R. Lesmana, T. A. Putranto, Y. F. Liaw, S. K. Sarin. Asian Pacific Association for the study of the liver consensus recommendations on hepatocellular carcinoma. <i>Hepatol. Int.<\/i> 4: 439\u2013474, 2010.","DOI":"10.1007\/s12072-010-9165-7"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) H. M. Gegner, T. Naake, A. Dugourd, T. M\u00fcller, F. Czernilofsky, G. Kliewer, E. J\u00e4ger, B. Helm, N. Kunze-Rohrbach, U. Klingm\u00fcller, C. Hopf, C. M\u00fcller-Tidow, S. Dietrich, J. Saez-Rodriguez, W. Huber, R. Hell, G. Poschet, J. Krijgsveld. Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis. <i>Front. Mol. Biosci.<\/i> 9: 961448, 2022.","DOI":"10.3389\/fmolb.2022.961448"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) J. Rappsilber, Y. Ishihama, M. Mann. Stop and go extraction tips for matrix-assisted laser desorption\/ionization, nanoelectrospray, and LC\/MS sample pretreatment in proteomics. <i>Anal. Chem.<\/i> 75: 663\u2013670, 2003.","DOI":"10.1021\/ac026117i"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) M. J. Rardin, B. Schilling, L. Y. Cheng, B. X. MacLean, D. J. Sorensen, A. K. Sahu, M. J. MacCoss, O. Vitek, B. W. Gibson. MS1 peptide ion intensity chromatograms in MS2 (SWATH) data independent acquisitions. Improving post acquisition analysis of proteomic experiments. <i>Mol. Cell. Proteomics<\/i> 14: 2405\u20132419, 2015.","DOI":"10.1074\/mcp.O115.048181"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Y. Huang, R. Shi, W. Gee, R. Bonderud. Matrix effect and recovery terminology issues in regulated drug bioanalysis. <i>Bioanalysis<\/i> 4: 271\u2013279, 2012.","DOI":"10.4155\/bio.11.315"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) D. Ball, E. Rose, E. Alpert. Alpha-fetoprotein levels in normal adults. <i>Am. J. Med. Sci.<\/i> 303: 157\u2013159, 1992.","DOI":"10.1097\/00000441-199203000-00004"}],"container-title":["Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/massspectrometry\/12\/1\/12_A0122\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T05:01:43Z","timestamp":1685163703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/massspectrometry\/12\/1\/12_A0122\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.5702\/massspectrometry.a0122","relation":{},"ISSN":["2186-5116","2187-137X"],"issn-type":[{"value":"2186-5116","type":"electronic"},{"value":"2187-137X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,24]]},"article-number":"A0122"}}