{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:53:43Z","timestamp":1792587223603,"version":"4.5.0"},"reference-count":65,"publisher":"Asian Australasian Association of Animal Production Societies","issue":"6","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023174","name":"Ministry of Education, Culture, Research and Technology","doi-asserted-by":"crossref","award":["082\/E5\/PG.02.00.PT\/2022"],"award-info":[{"award-number":["082\/E5\/PG.02.00.PT\/2022"]}],"id":[{"id":"10.13039\/501100023174","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["animbiosci.org"],"crossmark-restriction":true},"short-container-title":["Anim Biosci"],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:p>Objective: This study was conducted to evaluate the use of &lt;i&gt;Megasphaera elsdenii&lt;\/i&gt; (&lt;i&gt;M. elsdenii&lt;\/i&gt;) as a probiotic on rumen fermentation, production performance, carcass traits and health of ruminants by integrating data from various related studies using meta-analysis.Methods: A total of 32 studies (consisted of 136 data points) were obtained and integrated into a database. The parameters integrated were fermentation products, rumen microbes, production performance, carcass quality, animal health, blood and urine metabolites. Statistical analysis of the compiled database used a mixed model methodology. Different studies were considered random effects, while &lt;i&gt;M. elsdenii&lt;\/i&gt; supplementation doses were considered fixed effects. p-values and the Akaike information criterion were employed as model statistics. The model was deemed significant at p&lt;0.05 or had a tendency to be significant when p-value between 0.05\u3008p\u30080.10.Results: Supplementation with &lt;i&gt;M. elsdenii&lt;\/i&gt; increased (p&lt;0.05) some proportion of fermented rumen products such as propionate, butyrate, isobutyrate, and valerate, and significantly reduced (p&lt;0.05) lactic acid concentration, acetate proportion, total bacterial population and methane emission. Furthermore, the probiotic supplementation enhanced (p&lt;0.05) livestock production performance, especially in the average daily gain and body condition score. Regarding the carcass quality, hot carcass weight and carcass gain were elevated (p&lt;0.05) due to the &lt;i&gt;M. elsdenii&lt;\/i&gt; supplementation. Animal health also showed improvement as indicated by the lower (p&lt;0.05) diarrhoea and bloat incidences as well as the liver abscess. However, &lt;i&gt;M. elsdenii&lt;\/i&gt; supplementation had negligible effects on blood and urine metabolites of ruminants.Conclusion: Supplementation of &lt;i&gt;M. elsdenii&lt;\/i&gt; is capable of decreasing ruminal lactic acid concentration, enhancing rumen health, elevating some favourable rumen fermentation products, and in turn, increasing production performance of ruminants.<\/jats:p>","DOI":"10.5713\/ab.22.0258","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T06:55:32Z","timestamp":1673333732000},"page":"879-890","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Evaluation of Megasphaera elsdenii supplementation on rumen fermentation, production performance, carcass traits and health of ruminants: a meta-analysis"],"prefix":"10.5713","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-7098","authenticated-orcid":true,"given":"Irwan","family":"Susanto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0593-9653","authenticated-orcid":true,"given":"Komang  G.","family":"Wiryawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0542-4086","authenticated-orcid":true,"given":"Sri","family":"Suharti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-3832","authenticated-orcid":true,"given":"Yuli","family":"Retnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-3802","authenticated-orcid":true,"given":"Rika","family":"Zahera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-9770","authenticated-orcid":true,"given":"Anuraga","family":"Jayanegara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3683","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2007.04.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2527\/1998.761275x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2005.08.004"},{"key":"ref4","volume-title":"Digestive disorders and nutritional toxicity. 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