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This study aimed to investigate the effects of sodium alginate\/chitosan\/sodium alginate IgY microcapsules on the growth performance, serum parameters, and intestinal health of broiler chickens.Methods: One-day-old broilers (Ross 308) were divided into five treatments, each with 10 replicates of five chickens. The dietary treatments were maintained for 28 days and consisted of a basal diet (NC), basal diet + 500 mg chlortetracycline\/kg diet (CH), basal diet + 50 mg non-microencapsulated IgY\/kg diet (NM), basal diet + 600 mg low levels microencapsulated IgY\/kg diet (LM), and basal diet + 700 mg high levels microencapsulated IgY\/kg diet (HM).Results: Throughout the 28-day trial period, the NM, LM, HM, and CH groups increased average daily gain compared with the NC group (p&lt;0.05), and the HM group reduced feed conversion ratio compared with the CH group (p&lt;0.05). The LM and HM groups increased relative organ weights of thymus and spleen compared with the CH and NM groups (p&lt;0.05). The HM group improved the duodenal, jejunal and ileum villi height (VH) and villus height to crypt depth ratio (VH:CD) compared with the CH and NM groups (p&lt;0.05). Compared with the CH group, the HM group increased serum immunoglobulin (IgA), immunoglobulin G (IgG), superoxide dismutase, total antioxidant capacity, and glutathione peroxidase levels (p&lt;0.05), and decreased serum malondialdehyde levels (p&lt;0.05). Compared with the NC group, the NM, LM, HM, and CH groups reduced colonic &lt;i&gt;Escherichia coli&lt;\/i&gt; and Salmonella levels (p&lt;0.05). and the HM group promoted the levels of lactic acid bacteria and bifidobacteria compared with the CH group (p&lt;0.05).Conclusion: Microencapsulation could be considered as a way to improve the efficiency of IgY. The 700 mg high levels microencapsulated IgY\/kg diet could potentially be used as an alternative to antibiotics to improve the immune performance and intestinal health, leading to better performance of broiler chickens.<\/jats:p>","DOI":"10.5713\/ab.22.0414","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T06:42:46Z","timestamp":1677480166000},"page":"1241-1251","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of microencapsulation of egg yolk immunoglobulin Y by sodium alginate\/chitosan\/sodium alginate on the growth performance, serum parameters, and intestinal health of broiler 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