{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:23:12Z","timestamp":1783653792965,"version":"3.55.0"},"reference-count":44,"publisher":"Asian Australasian Association of Animal Production Societies","issue":"12","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2021YFE0111100"],"award-info":[{"award-number":["2021YFE0111100"]}]},{"name":"Sericulture comprehensive technology integration position","award":["CARS-18-ZJ0207"],"award-info":[{"award-number":["CARS-18-ZJ0207"]}]},{"name":"Ministry of Science and Technology of China","award":["KY202201002"],"award-info":[{"award-number":["KY202201002"]}]},{"name":"Science and Technology Partnership Program"},{"name":"Zhenjiang Science and Technology support project","award":["GJ2021015"],"award-info":[{"award-number":["GJ2021015"]}]},{"DOI":"10.13039\/501100017691","name":"Key Research and Development Program of Guangxi","doi-asserted-by":"crossref","award":["AB23026066"],"award-info":[{"award-number":["AB23026066"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agriculture Ministry","award":["111721301354052026"],"award-info":[{"award-number":["111721301354052026"]}]},{"name":"National Infrastructure for Crop Germplasm Resources","award":["NICGR-43"],"award-info":[{"award-number":["NICGR-43"]}]},{"name":"Postgraduate Research and Practice Innovation Program of Jiangsu Province","award":["SJCX22_1991"],"award-info":[{"award-number":["SJCX22_1991"]}]}],"content-domain":{"domain":["animbiosci.org"],"crossmark-restriction":true},"short-container-title":["Anim Biosci"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"Objective: The current study investigated the effects of mulberry 1-deoxynijirimycin (DNJ) on the digestion ability, intestinal morphology, and intestinal barrier of rabbits.Methods: A total of 36 New Zealand White rabbits (male) about 45 days old (mean body weight of 1.05\u00b10.04 kg) were reared and commercial diets were employed, and afterwards divided into three groups (n = 12) with different levels of DNJ extract additive in feed: T<sub>0<\/sub> (0 g\/kg), T<sub>1<\/sub> (0.35 g\/kg), T<sub>2<\/sub> (0.7 g\/kg) for 28 d.Results: The results demonstrated that T<sub>2<\/sub> decreased the average daily gain (p<0.05). T<sub>1<\/sub> and T<sub>2<\/sub> decreased villus height and inflammatory factor levels as compared with T<sub>0<\/sub> (p<0.05). DNJ significantly decreased the content of valeric acid (p<0.05). The content of acetic acid, propionic acid, iso butyric acid, iso valeric acid in T<sub>1<\/sub> were higher than those in T<sub>0<\/sub> and T<sub>2<\/sub> (p<0.05). The content of butyric acid in T<sub>2<\/sub> was lower than it in T<sub>0<\/sub> and T<sub>1<\/sub> (p<0.05). The content of caproic acid was firstly improved then reduced as the DNJ concentration improved (p<0.05). T<sub>2<\/sub> significantly increased the abundance of <i>dgA-11_gut_group<\/i> and <i>Christensenellaceae_R-7_group<\/i> while decreased <i>Bacteroide<\/i> and <i>Ralstonia<\/i> as compared with T<sub>0<\/sub> (p<0.05). Compared with T<sub>0<\/sub>, T<sub>1<\/sub>, and T<sub>2<\/sub> significantly improved the gene expression of <i>JAM2<\/i>, <i>JAM3<\/i>, <i>mucin4<\/i>, <i>mucin6<\/i> (p<0.05), T<sub>1<\/sub> significantly decreased the expression of occluding while T<sub>2<\/sub> significantly increased (p<0.05), T<sub>2<\/sub> significantly increased the expression of <i>claudin1<\/i> and <i>claudin2<\/i> (p<0.05).Conclusion: DNJ at high level changed microbiome compositions, inhibited inflammation, and improved intestinal barrier while it decreased the growth performance and shorted villus height in rabbit jejunum by regulating short chain fatty acid compositions in rabbits.<\/jats:p>","DOI":"10.5713\/ab.24.0109","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T07:44:51Z","timestamp":1724312691000},"page":"2101-2112","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dietary Mulberry leaf 1-deoxynijirimycin supplementation shortens villus height and improves intestinal barrier in fattening rabbits"],"prefix":"10.5713","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3268-723X","authenticated-orcid":true,"given":"Shaocong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-6311","authenticated-orcid":true,"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8093-8692","authenticated-orcid":true,"given":"Zijie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8411-3208","authenticated-orcid":true,"given":"Wenyu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-1471","authenticated-orcid":true,"given":"Qirui","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4628-1007","authenticated-orcid":true,"given":"Boris 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