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Two factors were F18+ E. coli challenge (0 or 2.1\u00d71010 colony-forming units [CFU]) and the level of SBM (24% or 12% in phase 1 and 26% or 14% in phase 2). Pigs were fed for 25 d in 2 phases (phase 1 for 11 d and phase 2 for 14 d). At the end of study, all pigs were euthanized to collect jejunal mucosa and tissues.Results: The F18+ E. coli challenge decreased (p&lt;0.05) overall average daily gain (ADG) and average daily feed intake (ADFI) and decreased (p&lt;0.05) gain to feed ratio on d 7 to 11. The high SBM tended to have a greater overall ADG (p = 0.054) and ADFI (p = 0.078) compared with low SBM under F18+ E. coli challenge, but not in unchallenged conditions. The F18+ E. coli challenge increased (p&lt;0.05) fecal score on d 7 to 18. The tumor necrosis factor-\u03b1 and interleukin-1\u03b2 in jejunal mucosa were decreased (p&lt;0.05) in high SBM treatments. The high SBM tended to increase (p = 0.085) occludin expression in jejunum. high SBM increased crypt depth in jejunum under F18+ E. coli challenge, but not in unchallenged conditions (p&lt;0.05).Conclusion: High SBM in nursery diets could alleviate the detrimental effects of F18+ E. coli challenge on growth performance of pigs under compared to low SBM inclusion, which might be attributed to decreased intestinal inflammation and improved intestinal integrity.<\/jats:p>","DOI":"10.5713\/ab.24.0566","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:04:17Z","timestamp":1730102657000},"page":"728-738","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impacts of replacing soybean meal with processed soybean meal on intestinal health and growth of nursery pigs challenged with F18+ Escherichia 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