{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:07:14Z","timestamp":1780463234388,"version":"3.54.1"},"reference-count":40,"publisher":"Asian Australasian Association of Animal Production Societies","issue":"12","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009591","name":"North Carolina Agricultural Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009591","id-type":"DOI","asserted-by":"publisher"}]},{"name":"USDA-NIFA Hatch Fund"}],"content-domain":{"domain":["animbiosci.org"],"crossmark-restriction":true},"short-container-title":["Anim Biosci"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:p>Objective: The objective was to evaluate the effects of replacing soybean meal (SBM) with enzyme-treated soy oligopeptide (ESO) in nursery pig diets on intestinal health, growth performance, and feed preference.Methods: In Exp. 1, 128 pigs (average 5.2 kg) were housed in pens (4 pigs\/pen), assigned to 4 diets supplemented with 0%, 1%, 2%, or 3% of ESO, and fed for 32 d. On d 32, blood, tissues, and mucosa from the duodenum and jejunum were collected. In Exp. 2, 24 pigs (average 6.2 kg) were assigned to 6 pens (4 pigs\/pen). Each pen had two separate feeders containing two diets with 0% or 2% of ESO for 27 d.Results: Increasing dietary ESO tended to quadratically change serum tumor necrosis factor-\u03b1 (p = 0.059; minimum at 1.6% of ESO) and duodenal villus height to crypt depth ratio (p = 0.062; maximum at 1.8% of ESO). Increasing dietary ESO linearly reduced feed intake both linearly and quadratically (p&lt;0.05) during phase 2 (maximum at 0.9% of ESO). Increasing dietary ESO both linearly and quadratically changed (p&lt;0.05) weight gain during phase 2 (maximum at 1.0% of ESO). Increasing dietary ESO linearly changed (p&lt;0.05) and tended to quadratically change (p = 0.077) weight gain during the overall phase. Increasing dietary ESO tended to linearly change (p = 0.059) gain to feed ratio during phase 1 and quadratically change (p&lt;0.05) gain to feed ratio during phase 2 (maximum at 1.4% of ESO). Feed preference of the diet containing 2% of ESO was negatively associated with post-weaning days (R2 = 0.542).Conclusion: Gradually replacing SBM with ESO at levels from 1.4% to 1.8% enhanced intestinal health and gain to feed ratio, whereas exceeding 0.9% to 1.0% reduced feed intake and weight gain, suggesting that optimal level of ESO in nursery pig diets is 0.9%.<\/jats:p>","DOI":"10.5713\/ab.25.0153","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T04:46:46Z","timestamp":1749530806000},"page":"2714-2725","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of enzyme-treated soy oligopeptide on intestinal health, feed preference, and growth performance in nursery 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