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Pigs\u2019 performance was recorded at 0, 7, 14 and 35 d of trial and their fecal consistency was assessed on the first 2 weeks. At 7 d, one piglet per pen (18 in total) was sampled for blood, intestinal mucosa, and bile. Blood serum calprotectin and citrulline and bile sIgA were quantified with ELISA, and gene expression in the mucosa from ileum, jejunum, and caecum was analyzed with high-throughput microfluidic technology.Results: Relative to control, SDPP improved feed intake (215 vs 280 g\/d; p&lt;0.05), weight gain (133 vs. 205 g\/d; p&lt;0.05) and gain-to-feed ratio (0.61 vs. 0.74; p&lt;0.05) between d 0 to 7. Serum calprotectin and citrulline, and bile sIgA at d 7 were not affected. Piglets fed SDPP had higher expressions of &lt;i&gt;IL-1\u03b2&lt;\/i&gt; (p = 0.033) in jejunal mucosa, and of &lt;i&gt;IL-1\u03b2&lt;\/i&gt; (p = 0.018), &lt;i&gt;IL-8\/CXCL8&lt;\/i&gt; (p = 0.010), &lt;i&gt;GBP1&lt;\/i&gt; (p = 0.014) and &lt;i&gt;TGF-\u03b21&lt;\/i&gt; (p = 0.015) in ileal mucosa, at 7 d post-weaning. No effects on fecal scores were observed.Conclusion: It is concluded that the administration of SDPP during the pre-starter phase improves piglet\u2019s performance during the first week post-weaning. These SDPP associated benefits appear to have been achieved through the modulation of gut homeostasis, potentially involving the regulation of inflammatory factors in the small intestinal mucosa.<\/jats:p>","DOI":"10.5713\/ab.25.0185","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T04:46:14Z","timestamp":1749530774000},"page":"2475-2486","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spray-dried porcine plasma improves piglets\u2019 performance and modulates gut immune-related genes in the first week post-weaning"],"prefix":"10.5713","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-9631","authenticated-orcid":true,"given":"Zacharia 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