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Consequently, precocious livestock are widely utilized in cross-breeding. This study aims to elucidate the key molecular mechanisms by which circular RNA (circRNA) regulates the sexual maturation of sexually precocious goats.Methods: In this study, we analyzed the circRNA expression profiles of hypothalamic tissue from Jining grey goats at four distinct postnatal developmental stages (1 day, 2 months, 4 months, 6 months).Results: A total of 23,993 circRNAs were identified across these stages, predominantly derived from exonic regions, with 1,052 circRNAs exhibiting differential expression. Additionally, competitive endogenous RNA (ceRNA) analysis suggested that novel_ circ_0002274\/chi-miR-197-5p\/ estrogen receptor 1 (ESR1) and novel_circ_0002274\/chimiR-30c-3p\/oxytocin\/neurophysin I prepropeptide (OXT) may regulate sexual maturation in goats via the estrogen signaling pathway and the oxytocin signaling pathway.Conclusion: This study contributes to understanding the function of circRNAs in hypothalamic regulation of sexual maturation and provides valuable insights for breeding superior goat breeds.<\/jats:p>","DOI":"10.5713\/ab.25.0275","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T02:11:23Z","timestamp":1750731083000},"page":"2545-2557","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of circular RNA (circRNA) characteristics and identification of key circRNAs in the hypothalamus during sexual maturation in female 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