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Growth performance, blood, and fecal samples were measured on regular basis. On day 30 of the trial, rumen fluid and fecal samples were collected for multi-omics analysis.Results: Dietary supplementation with AEPP enhanced calf growth and improved disease resistance, as evidenced by a reduced incidence of respiratory disease and diarrhea and a decreased frequency of antibiotic therapy (p&lt;0.05). The treatment group exhibited enrichment of rumen microorganisms Prevotella, Ruminococcus, and Xylanibacter (linear discriminant analysis&gt;2, p&lt;0.05), along with increased activity in beneficial metabolites such as indoleacetic acid, which activated starch and sucrose metabolism and tryptophan metabolism pathway. This intervetion significantly improved average daily gain, feed efficiency, immunoglobulin G, total superoxide dismutase, and glutathione peroxidase activities, as well as significantly reduced levels of tumor necrosis factor-alpha and interleukin-6 (p&lt;0.05), promoting calf growth and health. The elevated abundance of fecal microorganisms, Subdoligranulum and Bifidobacterium, in the treatment group altered fecal pH, short-chain fatty acids, and butyrate proportions (p&lt;0.05).Conclusion: Feeding AEPP improved growth performance, disease resistance, and antioxidant function. It altered the bacterial communities and metabolic profiles in the rumen and feces of preweaning dairy calves, providing a data reference for the use of AEPP in young ruminant production.<\/jats:p>","DOI":"10.5713\/ab.250112","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T01:41:22Z","timestamp":1763084482000},"page":"250112","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The additive from co-fermented edible plants and probiotics improved calves\u2019 growth performance and health by regulating antioxidant and 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