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Functional enrichment analysis showed that the source genes of these circRNAs are involved in key pathways such as immune response, lipid metabolism, and cell signaling. Persistently upregulated circRNAs (cluster 9) are related to tryptophan metabolism, potentially influencing the inflammatory response and energy homeostasis during weaning stress in young goats. In contrast, persistently downregulated circRNAs (cluster 0) may promote the change in liver metabolism from glucose to fatty acid oxidation by relieving inhibition on pathways such as AMPK and insulin signaling pathway. Based on the competitive endogenous RNA (ceRNA) mechanism, the study constructed a regulatory network consisting of 20 circRNAs, 15 microRNAs, and 21 mRNAs. Specifically chi-miR-532-3p\/CYP8B1\/circ101504503815046736, chi-miR-542-5p\/ACACB\/circ10_21217626_21219471, and miR-542-5p\/ACACB\/circ10-21217626-21219471 were identified as potential key ceRNA axes. Furthermore, this study confirmed the regulatory relationship among chi-miR-532-3p, CYP8B1 and circ10-21217626-21219471 through dual luciferase reporter gene experiments.Conclusion: This study reveals the dynamic expression profile of circRNA during goat liver development, suggesting its potential role in regulating metabolic and immune pathways through the ceRNA mechanism. This offers a novel perspective on post-transcriptional regulation in ruminant in liver development.<\/jats:p>","DOI":"10.5713\/ab.250689","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T04:49:35Z","timestamp":1764046175000},"page":"250689","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive analysis of circular RNA expression dynamics and competitive endogenous RNA network mechanisms during postnatal liver development in juvenile 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