{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:53:51Z","timestamp":1790906031379,"version":"4.1.0"},"reference-count":49,"publisher":"Asian Australasian Association of Animal Production Societies","issue":"10","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Science and Technology Program of Gansu Province","award":["25CXQH001"],"award-info":[{"award-number":["25CXQH001"]}]},{"name":"Key Science and Technology Program of Xinjiang Uygur Autonomous Region","award":["2025B04016-002-4"],"award-info":[{"award-number":["2025B04016-002-4"]}]},{"name":"Key Science and Technology Program of Jinchang City","award":["2024NY001z"],"award-info":[{"award-number":["2024NY001z"]}]}],"content-domain":{"domain":["animbiosci.org"],"crossmark-restriction":true},"short-container-title":["Anim Biosci"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>Objective: Cysteamine (CS) is known for its ability to regulate hormone secretion. Although widely used as a growth promoter for ruminants, long-term administration at high doses results in intestinal ulceration and growth retardation. We have previously demonstrated that long-term supplementing 20 mg CS\/kg body weight (BW) does not affect growth performance.Methods: This study aimed to elucidate the impacts of 30 mg CS kg-1 BW administered for 30 days on growth performance, hormonal profiles, rumen fermentation parameters, rumen bacterial communities, and muscle characteristics in Hu lambs. This dosage and duration regimen was effective in promoting growth performance while avoiding the ruminal negative effects observed at higher doses. Thirty-six male Hu lambs were randomly assigned to two groups.Results: The CS supplementation exhibited increased final BW, average daily gain, and dry matter intake during the first 21 days of the experimental period (p&lt;0.05). Hormonal analysis revealed that CS supplementation increased the levels of growth hormone, luteinizing hormone in the pituitary, testosterone (T) in the testis, and insulin-like growth factor I in the serumwhile decreasing the levels of somatostatin in the hypothalamus and serum (p&lt;0.05). Rumen fermentation analysis indicated an increase in total volatile fatty acids and the proportion of valerate (p&lt;0.05), while the proportion of acetate and the acetate\/propionate ratio decreased (p&lt;0.05). Muscle analysis revealed decreased mRNA expression levels of MyHCIIb (p&lt;0.05) in the longissimus dorsi muscle. Western blot analysis showed increased expression of mTOR proteins, along with an elevated phosphorylation level of mTOR (p&lt;0.05) in the longissimus dorsi muscle.Conclusion: Collectively, this study demonstrates that dietary CS supplementation enhances growth performance in Hu lambs by improving rumen function and modulating somatotropic axis hormones.<\/jats:p>","DOI":"10.5713\/ab.250803","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:17:01Z","timestamp":1782260221000},"page":"250803","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary supplementation of cysteamine promotes Hu lamb growth performance via somatotropic axis potentiation"],"prefix":"10.5713","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6151-3549","authenticated-orcid":true,"given":"Qinwu","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Grassland Agroecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6783-6218","authenticated-orcid":true,"given":"Tongtong","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Grassland Agroecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-8967","authenticated-orcid":true,"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Grassland Agroecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0143-4199","authenticated-orcid":true,"given":"Fadi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Grassland Agroecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3555-739X","authenticated-orcid":true,"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Grassland Agroecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4517-1104","authenticated-orcid":true,"given":"Tao","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Grassland Agroecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-1420","authenticated-orcid":true,"given":"Long","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Grassland Agroecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3683","reference":[{"key":"ref1","volume-title":"Pituitary growth hormone secretion and cell growth hormone production: regulation of their secretion and their signaling pathways","author":"Maria de Oliveira Ma","year":"2023","type":"book"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod53.4.882","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1079\/NRR200246","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5713\/ab.23.0245","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-02-00225.1982","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2527\/1995.73177x","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.10.025","type":"journal-article"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2025.116503","type":"journal-article"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1071\/AN14364","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.644","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1071\/EA06243","type":"journal-article"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021\/jf800575p","type":"journal-article"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-2076-5","type":"journal-article"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11930-021-00319-2","type":"journal-article"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2022.102045","type":"journal-article"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110999","type":"journal-article"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139393","type":"journal-article"},{"key":"ref18","volume-title":"","year":"2005","type":"book"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5713\/ab.25.0007","type":"journal-article"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(91)78551-2","type":"journal-article"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation10110542","type":"journal-article"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5713\/ab.250616","type":"journal-article"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731118003683","type":"journal-article"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.997091","type":"journal-article"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800007574","type":"journal-article"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(83)90124-6","type":"journal-article"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-6480(03)00268-5","type":"journal-article"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149461","type":"journal-article"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10061105","type":"journal-article"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac151","type":"journal-article"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-024-04188-4","type":"journal-article"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13616","type":"journal-article"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2020.114457","type":"journal-article"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2024.04.013","type":"journal-article"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2017.03.016","type":"journal-article"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.2.7250","type":"journal-article"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.9.8365","type":"journal-article"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.18.0414","type":"journal-article"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8619","type":"journal-article"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.2.371","type":"journal-article"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13251","type":"journal-article"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.122581","type":"journal-article"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102303","type":"journal-article"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.3.E383","type":"journal-article"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01147.2009","type":"journal-article"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31828cf5f3","type":"journal-article"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000173","type":"journal-article"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116184","type":"journal-article"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2018.05.006","type":"journal-article"}],"container-title":["Animal Bioscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/animbiosci.org\/upload\/pdf\/ab-250803.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/animbiosci.org\/journal\/view.php?doi=10.5713\/ab.250803","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/animbiosci.org\/upload\/pdf\/ab-250803.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:58:50Z","timestamp":1790902730000},"score":1,"resource":{"primary":{"URL":"http:\/\/animbiosci.org\/journal\/view.php?doi=10.5713\/ab.250803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"URL":"https:\/\/doi.org\/10.5713\/ab.250803","relation":{},"ISSN":["2765-0189","2765-0235"],"issn-type":[{"value":"2765-0189","type":"print"},{"value":"2765-0235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2025-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}