{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:23:56Z","timestamp":1787243036561,"version":"build-2736575974"},"reference-count":40,"publisher":"Asian Australasian Association of Animal Production Societies","issue":"7","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012657","name":"\u201cYoung Talents\u201d Project of Northeast Agricultural University","doi-asserted-by":"publisher","award":["20QC15"],"award-info":[{"award-number":["20QC15"]}],"id":[{"id":"10.13039\/501100012657","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["YQ2022C014"],"award-info":[{"award-number":["YQ2022C014"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["animbiosci.org"],"crossmark-restriction":true},"short-container-title":["Anim Biosci"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>Objective: Platycodon grandiflorum polysaccharide (PGP) extracted from Platycodon grandiflorum, which has the advantages of anti-inflammatory, antioxidant, anti-tumor, and no side effects on the organism. This study evaluated whether dietary PGP alleviates weaning-induced intestinal dysfunction in piglets.Methods: A total of 18 newly weaned piglets (6.46\u00b10.31 kg) were allocated to 3 treatments (n = 6\/group) for a 28-day feeding trial. The control group received a basal diet, while the L-PGP and H-PGP groups were supplemented with 1 g\/kg and 2 g\/kg PGP, respectively. On day 28, piglets were electrically stunned and euthanized by exsanguination; spleen, liver, and colon samples were collected to assess inflammatory\/antioxidant markers, barrierrelated genes, and colonic microbiota.Results: The supplementation of PGP increased the average daily gain (p&lt;0.05), and reduced the feed-to-gain ratio of weaned piglets. In addition, PGP reduced the expression of splenic IL-1\u03b2, IL-2, and IL-4 (p&lt;0.05). This effect was associated with upregulated mRNA levels of the key tight junction proteins Occludin, ZO\u20111, and Claudin\u20111 in the colonic mucosa and tissue (p&lt;0.05). Compared with the control group, the mRNA expression levels of PKC, Nrf2 and KEAP1 in the colonic tissue of weaned piglets were increased in the HPGP (p&lt;0.05). More importantly, H-PGP supplementation increased the relative abundances of Bacteroidota, while decreasing the abundance of Proteobacteria. Moreover, Spearman correlation analysis revealed that short-chain fatty acid-producing commensal genera (Faecalibacterium) were negatively correlated with pro-inflammatory cytokines and signaling genes, but positively correlated with antioxidant genes (p&lt;0.05). Conversely, the relative abundance of Escherichia\u2013Shigella was negatively correlated with the mRNA expression of PKC, Nrf2, and Keap1 (p&lt;0.05).Conclusion: PGP can alleviate the weaning stress in piglets, by modulating the colonic microbiota and enhancing systemic anti-inflammatory capacity and intestinal barrier function.<\/jats:p>","DOI":"10.5713\/ab.250877","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T01:17:57Z","timestamp":1776302277000},"page":"250877","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dietary supplementation of Platycodon grandiflorum polysaccharides mitigates weaning stress in piglets by modulating intestinal microbiota and improving gut health"],"prefix":"10.5713","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7486-5792","authenticated-orcid":true,"given":"Shusen","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6336-7624","authenticated-orcid":true,"given":"Mingming","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3659-6963","authenticated-orcid":true,"given":"Jiaqi","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9485-1088","authenticated-orcid":true,"given":"Jiajun","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9844-8992","authenticated-orcid":true,"given":"Haoyun","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5927-7596","authenticated-orcid":true,"given":"Yantong","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2628-869X","authenticated-orcid":true,"given":"Haotian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-2254","authenticated-orcid":true,"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2022-9665","authenticated-orcid":true,"given":"Haoyang","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3683","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-1891-4-19","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33649-8","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2016.1070","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2527\/jas2017.1757","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2009.04.010","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2013-6986","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-5796","type":"journal-article"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11112646","type":"journal-article"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.06.045","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2023.106635","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115318","type":"journal-article"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(25)60913-7","type":"journal-article"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.06.052","type":"journal-article"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1078593","type":"journal-article"},{"key":"ref15","volume-title":"","year":"2011","type":"book"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2020.07.003","type":"journal-article"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1039\/d2fo03673h","type":"journal-article"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2018-0275","type":"journal-article"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2024.01.012","type":"journal-article"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.13244","type":"journal-article"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2020.11.075","type":"journal-article"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1210890","type":"journal-article"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.07.008","type":"journal-article"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)61243-6","type":"journal-article"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108510","type":"journal-article"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/md19090525","type":"journal-article"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2015.12.003","type":"journal-article"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-021-00584-0","type":"journal-article"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183330","type":"journal-article"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092802","type":"journal-article"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.04.011","type":"journal-article"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4243210","type":"journal-article"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2022.2131806","type":"journal-article"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/srep44822","type":"journal-article"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1742082","type":"journal-article"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2018.10.002","type":"journal-article"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1081\/abio-120005768","type":"journal-article"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00402.x","type":"journal-article"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11030657","type":"journal-article"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25189826","type":"journal-article"}],"container-title":["Animal Bioscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/animbiosci.org\/upload\/pdf\/ab-250877.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/animbiosci.org\/journal\/view.php?doi=10.5713\/ab.250877","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/animbiosci.org\/upload\/pdf\/ab-250877.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:16:49Z","timestamp":1783063009000},"score":1,"resource":{"primary":{"URL":"http:\/\/animbiosci.org\/journal\/view.php?doi=10.5713\/ab.250877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"URL":"https:\/\/doi.org\/10.5713\/ab.250877","relation":{},"ISSN":["2765-0189","2765-0235"],"issn-type":[{"value":"2765-0189","type":"print"},{"value":"2765-0235","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"2025-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}