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Following a 42-day treatment period, intestinal microbiota, hepatic inflammatory response, and endoplasmic reticulum stress were evaluated.Results: BDE-209 caused severe intestinal damage, including shortened villi, increased crypt depth, disruption of tight junction structures, and ultrastructural abnormalities. Cur treatment alleviated these pathological changes, restoring tight junction protein expression and improving intestinal barrier function. Cur also cured BDE-209\u2011induced gut microbiota dysbiosis by increasing beneficial bacteria such as Lactobacillus and reducing harmful bacteria including Proteobacteria. Moreover, Cur lowered intestinal levels of key pro\u2011inflammatory cytokines. BDE\u2011209 caused significant liver damage, including histological lesions, hepatocyte ultrastructural damage, elevated blood liver enzymes, and oxidative stress. Cur improved liver function, lowered NF\u2011\u03baB and MAPK signaling pathways, and reduced the expression of endoplasmic reticulum stress\u2011related proteins and genes.Conclusion: Cur alleviated BDE-209-induced liver damage in broilers while also restoring gut microbiota and reduction of inflammation, and endoplasmic reticula stress.<\/jats:p>","DOI":"10.5713\/ab.250966","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:18:01Z","timestamp":1782260281000},"page":"250966","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin alleviates broiler liver damage caused by polybrominated diphenyl ether concurrent with restoring gut microbiota, reducing liver inflammation and endoplasmic reticulum 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