{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:15:45Z","timestamp":1788243345270,"version":"build-2803163510"},"reference-count":40,"publisher":"Asian Australasian Association of Animal Production Societies","issue":"9","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32060763"],"award-info":[{"award-number":["32060763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jilin Science and Technology Development Program","award":["YDZJ202501ZYTS485"],"award-info":[{"award-number":["YDZJ202501ZYTS485"]}]},{"name":"Jilin Province Doctoral Student Support Project","award":["BST202507"],"award-info":[{"award-number":["BST202507"]}]}],"content-domain":{"domain":["animbiosci.org"],"crossmark-restriction":true},"short-container-title":["Anim Biosci"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>Objective: This study aimed to investigate the effects and potential mechanisms of dietary glycerol monodecanoate (GMD) supplementation on gastrointestinal inflammation and oxidative stress in Yanbian cattle fed a high-concentrate diet.Methods: Thirty Yanbian cattle were randomly assigned to two groups: a control group (CON) fed a basal high-concentrate diet, and a treatment group (C10) fed the same basal diet supplemented with 60 g\/cattle\/day GMD. After a 10-day adaptation period, the experiment lasted 90 days. Collected samples (serum, rumen epithelium, abomasum, ileal mucosa) were analyzed for the following: gastrointestinal morphology (rumen and ileum); inflammatory, antioxidant, and oxidative stress indices (serum, rumen, and ileum); ghrelinrelated indices (serum and abomasum); and host transcriptomes (rumen and ileum).Results: GMD supplementation significantly reduced the levels of tumor necrosis factor\u2011\u03b1 and interleukin\u20111\u03b2 (IL\u20111\u03b2) in serum and rumen, as well as IL\u20111\u03b2 in the ileum. It also lowered oxidative stress, as indicated by lower reactive oxygen species in serum, rumen, and ileum. Concurrently, GMD increased antioxidant capacity by increasing levels of reduced glutathione and antioxidant enzymes. Beneficial trends in gastrointestinal morphology were noted in the C10 group, including increased ruminal papillae height and a higher ileal villus height-to-crypt depth ratio. Furthermore, the C10 group exhibited enhanced ghrelin acylation, with increased total ghrelin, acylated ghrelin and ghrelin O\u2011acyltransferase activity in both serum and abomasum. Transcriptomic analysis of the C10 group compared to the CON group revealed tissue-specific protective mechanisms: in the rumen epithelium, pro\u2011inflammatory pathways including NF\u2011\u03baB signaling were significantly suppressed, accompanied by down\u2011regulation of genes such as &lt;i&gt;IL1B&lt;\/i&gt; and &lt;i&gt;CXCL2&lt;\/i&gt;, whereas the ileal mucosal response was dominated by marked up\u2011regulation of &lt;i&gt;GSTA1&lt;\/i&gt;.Conclusion: GMD supplementation can reduce inflammation and oxidative stress in Yanbian cattle fed a high-concentrate diet. These effects may involve activation of ghrelin acylation and tissue-specific modulation of transcriptional programs in the rumen and ileum.<\/jats:p>","DOI":"10.5713\/ab.251032","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:49:13Z","timestamp":1775094553000},"page":"251032","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of dietary glycerol monodecanoate supplementation on inflammation, oxidative stress, ghrelin acylation, and gastrointestinal transcriptome in Yanbian cattle fed a high-concentrate diet"],"prefix":"10.5713","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-3096","authenticated-orcid":true,"given":"Xin","family":"Feng","sequence":"first","affiliation":[{"name":"Agricultural College, Yanbian University, Yanji, 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