{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:56:12Z","timestamp":1785236172436,"version":"3.55.0"},"reference-count":37,"publisher":"Asian Australasian Association of Animal Production Societies","issue":"7","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"key Projects of Science and Technology Plan of Zhejiang Province, China","award":["2015C02022"],"award-info":[{"award-number":["2015C02022"]}]},{"name":"Hangzhou Guogu Biological Technology Co., Ltd"}],"content-domain":{"domain":["ajas.info"],"crossmark-restriction":true},"short-container-title":["Asian-Australas J Anim Sci"],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:p>Objective: The aim of this study was to evaluate the effects of compound organic acid calcium (COAC) on growth performance, hepatic antioxidant status and intestinal barrier of male broilers under high ambient temperature (32.7\u00b0C).Methods: Nine hundred healthy one-d-old Cobb-500 male broiler chicks were randomly assigned into three groups with six replicates of 50 birds each. A basal diet supplemented with 0% (control), 0.4% and 0.8% COAC, respectively were fed to birds for 6 weeks. All treatments were under high ambient indoor temperature of 32.7\u00b0C, and had a constant calcium and available phosphorus ratio.Results: The results showed that, compared with control, the average daily gain of broilers in 0.4% and 0.8% was significantly increased and the ratio of feed to gain in in 0.4% and 0.8% was significantly decreased at 1 to 21, 22 to 42 and 1 to 42 days of age (p&lt;0.05). Compared with control, 0.8% COAC slightly decreased (p = 0.093) the content of malondialdehyde in liver at 42 days of age while 0.4% COAC significantly decreased (p&lt;0.05) the activity of alkaline phosphatase. Furthermore, 0.4% COAC significantly enhanced the intestinal barrier function via increasing jejunal and ileal ocln transcription, promoting jejunal mucin 2 transcription at 42 days of age (p&lt;0.05), and decreasing jejunal toll-like receptor 2 (TLR-2) and ileal TLR-15, inducible nitric oxide synthase compared with control group (p&lt;0.05). Whereas, no significant differences on the transcription of interleukin-1\u03b2 in jejunum and ileum were observed among three treatments (p&gt;0.05). Overall, heat stress caused by high natural environment temperature may induce the damage to hepatic antioxidation and intestinal barrier.Conclusion: Dietary inclusion of COAC can improve the tolerance of broilers to thermal environment through the modification of antioxidative parameters in liver and the mRNA expression of genes in intestinal barrier, resulting in an optimal inclusion level of 0.4%.<\/jats:p>","DOI":"10.5713\/ajas.19.0274","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T02:25:15Z","timestamp":1566786315000},"page":"1156-1166","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of compound organic acid calcium on growth performance, hepatic antioxidation and intestinal barrier of male broilers under heat 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