{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:00:01Z","timestamp":1790629201752,"version":"4.1.0"},"reference-count":34,"publisher":"Asian Australasian Association of Animal Production Societies","issue":"7","license":[{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31672511"],"award-info":[{"award-number":["31672511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key science and technology projects in Jilin province","award":["20170201004NY"],"award-info":[{"award-number":["20170201004NY"]}]}],"content-domain":{"domain":["animbiosci.org"],"crossmark-restriction":true},"short-container-title":["Anim Biosci"],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:p>Objective: Weaning is an important stage in the life of young mammals, which is associated with intestinal inflammation, gut microbiota disorders, and even death. \u03b2-Carotene displays anti\u2010inflammatory and antioxidant activities, which can prevent the development of inflammatory diseases. However, whether \u03b2-carotene can affect intestinal microbiota remains unclear. Methods: Twenty-four piglets were distributed into four groups: the normal suckling group (Con), the weaning group (WG), the weaning+\u03b2-carotene (40 mg\/kg) group (LCBC), and the weaning+\u03b2-carotene (80 mg\/kg) group (HCBC). The serum, jejunum, colon, and faeces were collected separately from each group. The effects of \u03b2-carotene on the phenotype, overall structure, and composition of gut microbiota were assessed in weaning piglets. Results: The results showed that \u03b2-carotene improved the growth performance, intestinal morphology and relieved inflammation. Furthermore, \u03b2-carotene significantly decreased the species from phyla &lt;i&gt;Bacteroidetes&lt;\/i&gt; and the genus &lt;i&gt;Prevotella&lt;\/i&gt;, and &lt;i&gt;Blautia&lt;\/i&gt;, and increased the species from the phyla &lt;i&gt;Firmicutes&lt;\/i&gt; and the genera &lt;i&gt;p-75-a5&lt;\/i&gt;, and &lt;i&gt;Parabacteroides&lt;\/i&gt; compared to the WG group. Spearman\u2019s correlation analysis showed that &lt;i&gt;Prevotella&lt;\/i&gt; and &lt;i&gt;Blautia&lt;\/i&gt; were positively correlated, and &lt;i&gt;Parabacteroides&lt;\/i&gt; and &lt;i&gt;Synergistes&lt;\/i&gt; were negatively correlated with the levels of interleukin-1\u03b2 (IL-1\u03b2), IL-6, and tumour necrosis factor-\u03b1 (TNF-\u03b1), while &lt;i&gt;p-75-a5&lt;\/i&gt; showed negative correlation with IL-6 in serum samples from piglets. Conclusion: These findings indicate that \u03b2-carotene could alleviate weaning-induced intestinal inflammation by modulating gut microbiota in piglets. &lt;i&gt;Prevotella&lt;\/i&gt; may be a potential target of \u03b2-carotene in alleviating the weaning-induced intestinal inflammation in piglets.<\/jats:p>","DOI":"10.5713\/ajas.19.0499","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T05:41:12Z","timestamp":1577166072000},"page":"1221-1234","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["\u03b2-Carotene prevents weaning-induced intestinal inflammation by modulating gut microbiota in 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