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Methods: Forty post-weaning gilts were randomly allocated to four groups and fed diets supplemented with 0, 0.5, 1.0, or 1.5 mg\/kg ZEA. Results: The results showed significant reductions in the activity of the antioxidant enzymes total superoxide dismutase and glutathione peroxidase and increases the malondialdehyde content with increasing concentrations of dietary ZEA. Immunohistochemical analysis supported these findings by showing a significantly increased expression of Nrf2 and glutathione peroxidase 1 (GPX1) with increasing concentrations of ZEA. The relative mRNA and protein expression of Nrf2, GPX1 increased linearly (p&lt;0.05) and quadratically (p&lt;0.05), which was consistent with the immunohistochemical results. The relative mRNA expression of Keap1 decreased linearly (p&lt;0.05) and quadratically (p&lt;0.05) in the duodenum as the ZEA concentration increased in the diet. The relative mRNA expression of modifier subunit of glutamate-cysteine ligase (GCLM) increased quadratically (p&lt;0.05) in all ZEA treatment groups and the relative mRNA expression of quinone oxidoreductase 1 (NQO1) catalytic subunit of glutamate-cysteine ligase decreased linearly (p&lt;0.05) and quadratically (p&lt;0.05) in the ZEA1.0 group and ZEA1.5 group. The relative protein expression of Keap1 and GCLM decreased quadratically (p&lt;0.05) in the duodenum as the ZEA concentration increased in the diet, respectively. The relative protein expression of NQO1 increased linearly (p&lt;0.05) and quadratically (p&lt;0.05) in all ZEA treatment groups in the duodenum. Conclusion: These findings suggest that ZEA regulates the expression of key factors of the Keap1-Nrf2 signaling pathway in the duodenum, which enables resistance to ZEA-induced oxidative stress. Further studies are needed to examine the effects of ZEA induced oxidative stress on other tissues and organs in post-weaning gilts.<\/jats:p>","DOI":"10.5713\/ajas.20.0384","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T04:53:56Z","timestamp":1602564836000},"page":"1403-1414","update-policy":"https:\/\/doi.org\/10.5713\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Zearalenone regulates key factors of the Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1\u2013nuclear factor erythroid 2-related factor 2 signaling pathway in duodenum of post-weaning gilts"],"prefix":"10.5713","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5988-446X","authenticated-orcid":true,"given":"Qun","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-0322","authenticated-orcid":true,"given":"Shu 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