{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:08:45Z","timestamp":1776132525533,"version":"3.50.1"},"reference-count":23,"publisher":"Becaris Publishing Limited","issue":"6","funder":[{"name":"the National Key Research and Development Program of China","award":["2018YFC0114703"],"award-info":[{"award-number":["2018YFC0114703"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>\n            <jats:bold>Aim:<\/jats:bold>\n            To examine prenatal diagnosis strategies through fetal karyotype analysis for 3117 pregnant women with genetic amniocentesis indications.\n            <jats:bold>Materials &amp; methods:<\/jats:bold>\n            According to the different indications for amniocentesis, the study was divided into 8 groups. The number of amniocentesis specimens, the number of abnormal karyotypes and the positive rate of each group were analyzed.\n            <jats:bold>Results:<\/jats:bold>\n            Compared with prenatal serum screening, noninvasive prenatal DNA\u00a0testing is more accurate and can effectively improve screening efficiency. Multiple prenatal diagnosis indicators (37.349%) were more likely to be detected than single prenatal diagnosis indicators (11.091%).\n            <jats:bold>Conclusion:<\/jats:bold>\n            None of the screening methods can completely replace amniocentesis, and for pregnant women with genetic indications for amniocentesis, amniocentesis is strongly recommended.\n          <\/jats:p>","DOI":"10.57264\/cer-2022-0168","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T14:30:47Z","timestamp":1685543447000},"source":"Crossref","is-referenced-by-count":13,"title":["Amniotic fluid karyotype analysis and prenatal diagnosis strategy of 3117 pregnant women with amniocentesis indication"],"prefix":"10.57264","volume":"12","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[{"name":"Medical Genetics, Zibo Maternal &amp; Child Health Hospital, Zibo, 255000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1689-2627","authenticated-orcid":false,"given":"Xue-Cheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Medical Genetics, Zibo Maternal &amp; Child Health Hospital, Zibo, 255000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Jian","family":"Lv","sequence":"additional","affiliation":[{"name":"Medical Genetics, Zibo Maternal &amp; Child Health Hospital, Zibo, 255000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Genetics, Zibo Maternal &amp; Child Health Hospital, Zibo, 255000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[{"name":"Medical Genetics, Zibo Maternal &amp; Child Health Hospital, Zibo, 255000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Mu","sequence":"additional","affiliation":[{"name":"Medical Genetics, Zibo Maternal &amp; Child Health Hospital, Zibo, 255000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"issue":"7143","key":"e_1_3_6_3_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0140-6736(60)91326-X","article-title":"Antenatal determination of fetal sex: in prevention of hereditary diseases","volume":"276","author":"Riis P","year":"1960","unstructured":"Riis P, Fuchs F. 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