{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:50:34Z","timestamp":1787032234527,"version":"build-2736575974"},"reference-count":19,"publisher":"Becaris Publishing Limited","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    Exploring the healthcare costs and resource use among privately insured US patients with post-traumatic stress disorder (PTSD).\n                    <jats:bold>Methods:<\/jats:bold>\n                    This study used Merative MarketScan data. The index date was defined as the first PTSD claim. Study period included a 1-year pre-index and 2-year post-index follow-up. Cases with only acute PTSD, cancer, or insurance gap during the study period were excluded. The PTSD with (PwC) and PTSD without comorbidities (PwoC) cohorts were defined by the presence\/absence of comorbid mental health conditions (schizophrenia, bipolar and major depressive disorder). Baseline PTSD (BP) cohort included PwoC cases with only index PTSD event and without FDA-approved PTSD medications or psychotherapy. Sub-analysis is conducted among patients with PTSD and substance\/alcohol use disorder. Study cohorts were matched in a 1:1:1 ratio.\n                    <jats:bold>Results:<\/jats:bold>\n                    The matched sample included 5076 patients (1681 PwC, 1681 PwoC, 1714 BP). PwC patients had higher 2-year PTSD-related costs than PwoC and BP patients ($3762 vs $1750 and $841; all p\u00a0&lt;\u00a00.001). The same trend was noted among all-cause and anxiety-related costs. PwC patients had higher 2-year PTSD-related inpatient and emergency department (ED) rates than PwoC (10.2% vs 1.7% and 6.8% vs 2.6%, all p\u00a0&lt;\u00a00.001) and inpatient and outpatient rates than BP (10.2% vs 2.1% and 98.0% vs 93.1%; all p\u00a0\u2264\u00a00.004). The sub-analysis had 3776 patients (3154 PwC, 537 PwoC, 85 BP). PwC had higher 2-year PTSD-related costs than PwoC and BP ($7668 vs $2919 and $1,483; all p\u00a0&lt;\u00a00.001). The same trend was noted in all-cause and anxiety-related costs. PwC also had higher 2-year PTSD-related inpatient and ED rates than PwoC (25.6% vs 10.4% and 12.7% vs 5.2%; all p\u00a0&lt;\u00a00.001) and inpatient and outpatient rates than BP (25.6% vs 8.2% and 95.5% vs 84.7%; all p\u00a0&lt;\u00a00.001).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    PTSD is associated with high healthcare costs and resource use. The highest economic burden was observed in patients with PTSD and mental health comorbidities.\n                  <\/jats:p>","DOI":"10.57264\/cer-2024-0058","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T08:56:51Z","timestamp":1731488211000},"source":"Crossref","is-referenced-by-count":4,"title":["Healthcare costs and resource utilization of patients with chronic post-traumatic stress disorder: a retrospective US claims analysis of commercially insured patients"],"prefix":"10.57264","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-8940","authenticated-orcid":false,"given":"Filip","family":"Stanicic","sequence":"first","affiliation":[{"name":"Health Economics &amp; Outcomes Research Department, ZRx Outcomes Research Inc., Mississauga, ON L5A 2X7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-4491","authenticated-orcid":false,"given":"Vladimir","family":"Zah","sequence":"additional","affiliation":[{"name":"Health Economics &amp; Outcomes Research Department, ZRx Outcomes Research Inc., Mississauga, ON L5A 2X7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4962-4396","authenticated-orcid":false,"given":"Dimitrije","family":"Grbic","sequence":"additional","affiliation":[{"name":"Health Economics &amp; Outcomes Research Department, ZRx Outcomes Research Inc., Mississauga, ON L5A 2X7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra de","family":"Angelo","sequence":"additional","affiliation":[{"name":"Lykos Therapeutics, 3141 Stevens Creek Blvd #40547, San Jose, CA 95117, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Bibeau","sequence":"additional","affiliation":[{"name":"Lykos Therapeutics, 3141 Stevens Creek Blvd #40547, San Jose, CA 95117, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36897","reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-5\u2122 (5th Edition)","author":"American Psychological Association","year":"2013","unstructured":"American Psychological Association. 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