{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:42:22Z","timestamp":1772822542871,"version":"3.50.1"},"reference-count":29,"publisher":"Becaris Publishing Limited","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To compare oral corticosteroid (OCS) burden and healthcare resource utilization (HCRU) in patients with chronic rhinosinusitis with nasal polyps undergoing functional endoscopic sinus surgery (FESS; intervention) versus not undergoing FESS.\n                    <jats:bold>Materials &amp; methods:<\/jats:bold>\n                    Retrospective cohort study using US claims data (Optum\u2019s de-identified Clinformatics\n                    <jats:sup>\u00ae<\/jats:sup>\n                    Data Mart Database; 2011\u20132021). Groups were propensity score (PS) matched to adjust for confounding. OCS burden (cumulative dose in mg prednisone equivalents) and HCRU were assessed during baseline (365\u00a0days pre-index), intervention (days 0\u201344), and follow-up (days 45\u2013365); costs during intervention and follow-up.\n                    <jats:bold>Results:<\/jats:bold>\n                    Before PS-matching, both groups had substantial comorbidity burden (&gt;50% allergic rhinitis; &gt;25% asthma) and over half of patients had used OCS (65% [FESS] vs 52% [non-FESS]; p\u00a0&lt;\u00a00.01). After PS-matching (n\u00a0=\u00a08909 per group), OCS cumulative dose during follow-up was 18% lower among FESS versus non-FESS patients (mean difference: -40\u00a0mg per patient [95% CI: -57, -23; p\u00a0&lt;\u00a00.01]). Similar proportions of patients filled OCS prescriptions during follow-up (35% [FESS], 36% [non-FESS]) and in these patients, OCS burden remained high (mean [SD] cumulative dose 521 [786] vs 612 [906] mg, respectively). Mean total healthcare costs per patient during the intervention period were $28,832 (FESS) and $2537 (non-FESS), but similar during follow-up ($15,659 and $15,926, respectively). HCRU was similar in follow-up, except more FESS patients visited an otolaryngologist (57% vs 32%, p\u00a0&lt;\u00a00.01).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    In US clinical practice, OCS burden in patients with chronic rhinosinusitis with nasal polyps was significantly lower but remained substantial following FESS, and HCRU and costs during follow-up were similar to matched patients without FESS.\n                  <\/jats:p>","DOI":"10.57264\/cer-2025-0065","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:06:56Z","timestamp":1770811616000},"source":"Crossref","is-referenced-by-count":0,"title":["Treatment burden and healthcare resource utilization in patients with chronic rhinosinusitis with nasal polyps who did or did not undergo functional endoscopic sinus surgery: a US real-world retrospective cohort study"],"prefix":"10.57264","volume":"15","author":[{"given":"Danielle L","family":"Isaman","sequence":"first","affiliation":[{"name":"Sanofi, Cambridge, MA 02141, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Corbett","sequence":"additional","affiliation":[{"name":"Global Medical Affairs, Sanofi, Morristown, NJ 08807, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella E","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology \u2013 Head &amp; Neck Surgery, Brigham &amp; Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju T","family":"Peters","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology and the Sinus and Allergy Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head &amp; Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sietze","family":"Reitsma","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head &amp; Neck Surgery, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, 1081 HV, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Petruski-Ivleva","sequence":"additional","affiliation":[{"name":"Sanofi, Cambridge, MA 02141, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Nash","sequence":"additional","affiliation":[{"name":"Medical Affairs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juby A","family":"Jacob-Nara","sequence":"additional","affiliation":[{"name":"Global Medical Affairs, Sanofi, Morristown, NJ 08807, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"36897","reference":[{"key":"e_1_3_9_3_2","doi-asserted-by":"crossref","first-page":"761388","DOI":"10.3389\/falgy.2021.761388","article-title":"Patients unmet needs in chronic rhinosinusitis with nasal polyps care: a patient advisory board statement of EUFOREA","volume":"2","author":"Claeys N","year":"2021","unstructured":"Claeys N, Teeling MT, Legrand P Patients unmet needs in chronic rhinosinusitis with nasal polyps care: a patient advisory board statement of EUFOREA. 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