{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:18:23Z","timestamp":1788265103582,"version":"build-2803163510"},"reference-count":58,"publisher":"Becaris Publishing Limited","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    This nationwide cohort study primarily aimed to descriptively characterize real-world treatment patterns, including treatment initiation, adherence, treatment duration and discontinuation of the first treatment drug, among patients who experienced a recurrent osteoporotic fracture.\n                    <jats:bold>Materials &amp; methods:<\/jats:bold>\n                    This population-based, retrospective cohort study used data from the Health Insurance Review and Assessment Database of South Korea. It included male and female patients aged 55\u00a0years and older who experienced a recurrent osteoporotic fracture within 2 years of their index fracture in 2013.\n                    <jats:bold>Results:<\/jats:bold>\n                    The study period was from 1 January 2012 to 31 December 2021, with an outcome assessment period from 1 January 2013 to 31 December 2017. A total of 34,558 patients with recurrent osteoporotic fractures were observed, and just over half (n\u00a0=\u00a018,462, 53.4%) received osteoporosis medication, with a significant difference in medication rates between males (23.7%) and females (58.8%) (p &lt; 0.001). The estimated median duration of osteoporosis medication was 146\u00a0days (interquartile range: 61\u2013365\u00a0days). The discontinuation rate of medication within 2 years of follow-up after their recurrent fracture was 80.5%, with the highest discontinuation rate (90.4%) observed among patients taking daily oral bisphosphonate medication.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Although patients with recurrent fractures require intensive management, our results showed a significant unmet need in the initiation and persistence of osteoporosis medication. Therefore, it is crucial to establish a strategic treatment approach to address the treatment gap in managing osteoporosis among very high-risk patients.\n                    <jats:bold>Dataset name:<\/jats:bold>\n                    Health Insurance Review and Assessment Database of South Korea.\n                  <\/jats:p>","DOI":"10.57264\/cer-2026-0039","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:51:49Z","timestamp":1785757909000},"source":"Crossref","is-referenced-by-count":0,"title":["Treatment gaps in osteoporosis care following recurrent fractures: a nationwide cohort study"],"prefix":"10.57264","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-2429","authenticated-orcid":false,"given":"Hyun Jin","family":"Han","sequence":"first","affiliation":[{"name":"Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, South Korea"},{"name":"Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University, Seoul, South Korea"},{"name":"College of Pharmacy, Kyung Hee University, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9844-9145","authenticated-orcid":false,"given":"Miryoung","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Kyung Hee University, Republic of Korea"},{"name":"College of Pharmacy, Sunchon National University, Suncheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyoung","family":"Wang","sequence":"additional","affiliation":[{"name":"Value Access &amp; Policy, Amgen Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Value Access &amp; Policy, Amgen Korea, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3445-6607","authenticated-orcid":false,"given":"Hae Sun","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, South Korea"},{"name":"Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University, Seoul, South Korea"},{"name":"College of Pharmacy, Kyung Hee University, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36897","reference":[{"key":"e_1_3_11_3_2","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00198-017-3911-9","article-title":"The importance of physical function to people with osteoporosis","volume":"28","author":"Kerr C","year":"2017","unstructured":"Kerr C, Bottomley C, Shingler S The importance of physical function to people with osteoporosis. 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