{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:18:15Z","timestamp":1788265095276,"version":"build-2803163510"},"reference-count":20,"publisher":"Becaris Publishing Limited","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comp. Eff. Res."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To compare the healthcare resource utilization, spending and clinical outcomes associated with porcine placental extracellular matrix (PPECM [InnovaMatrix\n                    <jats:sup>\u00ae<\/jats:sup>\n                    AC, Convatec Triad Life Sciences, LLC, TN, USA]) versus standard of care (SOC) and other advanced treatments (AT) among Medicare Fee-For-Service beneficiaries with diabetic foot ulcers (DFU) or venous leg ulcers (VLU).\n                    <jats:bold>Materials &amp; methods:<\/jats:bold>\n                    A retrospective cohort study was conducted using 100% Medicare Parts A and B administrative claims from October 2021 through December 2024. Treatment episodes for DFU and VLU were identified and categorized as PPECM plus SOC, SOC alone or AT plus SOC. Patients were followed for 6 months after the end of each treatment episode. Outcomes included post-episode healthcare utilization by site of care, per-patient-per-month spending, wound-related complications and amputations.\n                    <jats:bold>Results:<\/jats:bold>\n                    The final study sample included 109,786 eligible DFU patients (117,633 episodes of care; PPECM 0.2%, SOC 95.0%, AT 4.8%) and 53,624 eligible VLU patients (56,498 episodes of care; PPECM 0.1%, SOC 95.5%, AT 4.4%). In DFU, PPECM was associated with significantly lower post-episode utilization in most sites of care compared with SOC, and fewer wound complications including amputations compared with AT. Although total post-episode costs were higher for PPECM than SOC and AT in DFU, PPECM had lower overall cost at specific types of care sites. In VLU, PPECM was associated with significantly fewer visits across most sites of care compared with AT and SOC. PPECM-treated VLU episodes had significantly lower total costs than both SOC and AT. Rates of wound complications and amputations were similar across treatment groups in VLU.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Treatment with PPECM demonstrated lower overall post-episode costs compared with SOC and other AT while maintaining safety outcomes, particularly in VLU, suggesting potential value in chronic wound management.\n                  <\/jats:p>","DOI":"10.57264\/cer-2026-0063","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:27:56Z","timestamp":1787059676000},"source":"Crossref","is-referenced-by-count":0,"title":["Health resource utilization and cost analysis in Medicare beneficiaries with chronic wounds: outcomes with porcine placental extracellular matrix versus standard of care and other advanced treatments"],"prefix":"10.57264","volume":"15","author":[{"given":"Jenny","family":"Levinson","sequence":"first","affiliation":[{"name":"Convatec Ltd, Lexington, MA 02421, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4466-5968","authenticated-orcid":false,"given":"Janet","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"Convatec Ltd, Lexington, MA 02421, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Decker","sequence":"additional","affiliation":[{"name":"Convatec Ltd, Lexington, MA 02421, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7098-9140","authenticated-orcid":false,"given":"Serena","family":"Nally","sequence":"additional","affiliation":[{"name":"Convatec Ltd, Lexington, MA 02421, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5795-2576","authenticated-orcid":false,"given":"Irene","family":"Varghese","sequence":"additional","affiliation":[{"name":"ADVI Health LLC, Washington, DC 20004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5332-8832","authenticated-orcid":false,"given":"Caitlin","family":"Sheetz","sequence":"additional","affiliation":[{"name":"ADVI Health LLC, Washington, DC 20004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5535-4709","authenticated-orcid":false,"given":"Peter","family":"Kardel","sequence":"additional","affiliation":[{"name":"ADVI Health LLC, Washington, DC 20004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8084-8818","authenticated-orcid":false,"given":"Cristin","family":"Taylor","sequence":"additional","affiliation":[{"name":"Convatec Ltd, Lexington, MA 02421, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"36897","reference":[{"issue":"9","key":"e_1_3_11_3_2","doi-asserted-by":"crossref","first-page":"e70756","DOI":"10.1111\/iwj.70756","article-title":"Comparison of single use and traditional negative pressure wound therapy devices in lower extremity ulcers: a US real-world evidence analysis of NetHealth Data","volume":"22","author":"Garten A","year":"2025","unstructured":"Garten A, Nherera LM, Lindsay R. Comparison of single use and traditional negative pressure wound therapy devices in lower extremity ulcers: a US real-world evidence analysis of NetHealth Data. Int. Wound J. 22(9), e70756 (2025).","journal-title":"Int. Wound J."},{"issue":"1","key":"e_1_3_11_4_2","doi-asserted-by":"crossref","DOI":"10.63676\/5waqaz41","article-title":"Cold atmospheric plasma: a new modality to treat chronic diabetic foot ulcers, venous leg ulcers, and pressure ulcers","volume":"1","author":"Serena TE","year":"2025","unstructured":"Serena TE, Garcia L, Neil M Cold atmospheric plasma: a new modality to treat chronic diabetic foot ulcers, venous leg ulcers, and pressure ulcers. IJTR 1(1), doi: 10.63676\/5waqaz41 (2025) (Epub ahead of print).","journal-title":"IJTR"},{"issue":"7","key":"e_1_3_11_5_2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.12968\/jowc.2021.30.Sup7.S5","article-title":"Observed impact of skin substitutes in lower extremity diabetic ulcers: lessons from the Medicare Database (2015\u20132018)","volume":"30","author":"Armstrong DG","year":"2021","unstructured":"Armstrong DG, Tettelbach WH, Chang TJ Observed impact of skin substitutes in lower extremity diabetic ulcers: lessons from the Medicare Database (2015\u20132018). J. Wound Care 30(Suppl. 7), S5\u2013S16 (2021).","journal-title":"J. Wound Care"},{"issue":"3","key":"e_1_3_11_6_2","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.12968\/jowc.2024.33.Sup3.S24","article-title":"Dehydrated human amnion\/chorion membrane to treat venous leg ulcers: a cost-effectiveness analysis","volume":"33","author":"Tettelbach WH","year":"2024","unstructured":"Tettelbach WH, Driver V, Oropallo A Dehydrated human amnion\/chorion membrane to treat venous leg ulcers: a cost-effectiveness analysis. J. Wound Care 33(Suppl. 3), S24\u2013S38 (2024).","journal-title":"J. Wound Care"},{"issue":"1","key":"e_1_3_11_7_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic foot ulcers: a review","volume":"330","author":"Armstrong DG","year":"2023","unstructured":"Armstrong DG, Tan T-W, Boulton AJM, Bus SA. Diabetic foot ulcers: a review. 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Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers. Diabetes Care 46(1), 209\u2013221 (2023).","journal-title":"Diabetes Care"},{"issue":"4","key":"e_1_3_11_11_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/jowc.2023.32.Sup4b.S1","article-title":"Best practice for wound repair and regeneration use of cellular, acellular and matrix-like products (CAMPs)","volume":"32","author":"Wu S","year":"2023","unstructured":"Wu S, Carter M, Cole W Best practice for wound repair and regeneration use of cellular, acellular and matrix-like products (CAMPs). J. Wound Care 32(Suppl. 4b), S1\u2013S31 (2023).","journal-title":"J. Wound Care"},{"key":"e_1_3_11_12_2","doi-asserted-by":"crossref","first-page":"1154567","DOI":"10.3389\/fmed.2023.1154567","article-title":"Skin substitutes as treatment for chronic wounds: current and future directions","volume":"10","author":"Vecin NM","year":"2023","unstructured":"Vecin NM, Kirsner RS. Skin substitutes as treatment for chronic wounds: current and future directions. Front. Med. 10, 1154567 (2023).","journal-title":"Front. Med."},{"issue":"12","key":"e_1_3_11_13_2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1089\/wound.2023.0075","article-title":"Systematic review of cellular, acellular, and matrix-like products and indirect treatment comparison between cellular\/acellular and amniotic\/nonamniotic grafts in the management of diabetic foot ulcers","volume":"13","author":"Banerjee J","year":"2024","unstructured":"Banerjee J, Lasiter A, Nherera L. Systematic review of cellular, acellular, and matrix-like products and indirect treatment comparison between cellular\/acellular and amniotic\/nonamniotic grafts in the management of diabetic foot ulcers. Adv. Wound Care 13(12), 639\u2013651 (2024).","journal-title":"Adv. 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Wounds 16(1), 18\u201322 (2004).","journal-title":"Wounds"},{"issue":"5","key":"e_1_3_11_17_2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jvs.2005.01.042","article-title":"Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: a randomized clinical trial","volume":"41","author":"Mostow EN","year":"2005","unstructured":"Mostow EN, Haraway GD, Dalsing M, Hodde JP, King D. Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: a randomized clinical trial. J. Vasc. Surg. 41(5), 837\u2013843 (2005).","journal-title":"J. Vasc. 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Kidney J."}],"container-title":["Journal of Comparative Effectiveness Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/becarispublishing.com\/doi\/pdf\/10.57264\/cer-2026-0063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:45:13Z","timestamp":1788263113000},"score":1,"resource":{"primary":{"URL":"https:\/\/becarispublishing.com\/doi\/10.57264\/cer-2026-0063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.57264\/cer-2026-0063"],"URL":"https:\/\/doi.org\/10.57264\/cer-2026-0063","relation":{},"ISSN":["2042-6305","2042-6313"],"issn-type":[{"value":"2042-6305","type":"print"},{"value":"2042-6313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"article-number":"e260063"}}