{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:31:53Z","timestamp":1790728313855,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A stability-indicating micellar electrokineticchromatography (MEKC) method was developed and validated for simultaneous analysis of delapril (DEL) and manidipine (MAN) using salicylic acid as an internal standard. The MEKC method was performed using a fused-silica capillary (effective length of 72 cm) with 50 mM of borate buffer and 5 mM of anionic surfactant sodium dodecylsulfate at pH9.0 as the background electrolyte. The separationwas achieved at 25 kV applied voltage and 35\u00b0C. The injection was performed at 50 mbar for5s, with detection at 208 nm. The method was linear in the range of 15\u2013150 \u03bcg\/mL (r2 = 0.9966) for DEL and 5\u201350 \u03bcg\/mL (r2 = 0.9985) for MAN with adequate results for the precision (\u22641.87%) and accuracy (98.94% for DEL and 100.65% for MAN). The specificity of the method and its stability-indicating capability was demonstrated through forced degradation studies, which showed that there was no interference from the excipients. The Plackett-Burman experimental design was used for robustness evaluation, giving results within the acceptable range. The method was successfully applied for analysis of the drugs, and the results were compared to an LC method, resulting in nonsignificant differences (P = 0.78 and0.84 for DEL and MAN, respectively).<\/jats:p>","DOI":"10.5740\/jaoacint.10-337","type":"journal-article","created":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T23:40:56Z","timestamp":1391470856000},"page":"114-120","source":"Crossref","is-referenced-by-count":4,"title":["Stability-Indicating Micellar Electrokinetic Chromatography Technique for Simultaneous Measurement of Delapril and Manidipine from a Combination Drug Formulation"],"prefix":"10.1093","volume":"97","author":[{"given":"V\u00edtor","family":"Todeschini","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro, Faculty of Pharmacy, 27930-560 Maca\u00e9-RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"da Silva Sangoi","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro, Faculty of Pharmacy, 27930-560 Maca\u00e9-RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alianise","family":"da Silva Meira","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Faculty of Pharmacy, 90610-000 Porto Alegre-RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Miron","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Faculty of Pharmacy, 90610-000 Porto Alegre-RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alini Dall Cortivo","family":"Lange","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Faculty of Pharmacy, 90610-000 Porto Alegre-RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia Maria","family":"Volpato","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul, Faculty of Pharmacy, 90610-000 Porto Alegre-RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,27]]},"container-title":["Journal of AOAC INTERNATIONAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/97\/1\/114\/32425708\/jaoac0114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/97\/1\/114\/32425708\/jaoac0114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T18:10:16Z","timestamp":1584641416000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaoac\/article\/97\/1\/114-120\/5654658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2014,1,1]]}},"URL":"https:\/\/doi.org\/10.5740\/jaoacint.10-337","relation":{},"ISSN":["1060-3271","1944-7922"],"issn-type":[{"value":"1060-3271","type":"print"},{"value":"1944-7922","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,1,1]]},"published":{"date-parts":[[2014,1,1]]}}}