{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:25:22Z","timestamp":1774340722482,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A selective, accurate, precise, and highly sensitive HPTLC assay with reflectance\/fluorescence densitometry was developed to separate and quantify some angiotensin II receptor blockers (ARBs), namely, losartan potassium, irbesartan, valsartan, and olmesartan medoxomil, in tablets and plasma. Separation of the target ARBs was performed on precoated silica gel HPTLC plates developed using chloroform\u2013glacial acetic acid (7.5 + 2.5, v\/v) mobile phase. The drugs were adequately resolved. After the exposure of the chromatograms to concentrated hydrochloric acid vapor for 10 min, the scanner was set in the reflectance\/fluorescence mode with 255 nm excitation wavelength and &amp;gt;400 nm emission filter. The linear regression analysis data for the calibration curves of all studied drugs produced a good linear relationshipwith correlation coefficients ranging from 0.9991 to0.9999 over the concentration range of 2\u201320 ng\/band. LOD and LOQ values of all studied drugs ranged from 0.6 to 0.8 and from 1.7 to 2.4 ng\/band, respectively. The developed method was successfully applied for analysis of the target ARBs in tablets and spiked human plasma samples with good precision and accuracy.<\/jats:p>","DOI":"10.5740\/jaoacint.14-179","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:03:34Z","timestamp":1429747414000},"page":"354-360","source":"Crossref","is-referenced-by-count":22,"title":["HPTLC with Fluorescence Densitometry for Simultaneous Determination of Some Angiotensin II Receptor Blockers in Tablets and Plasma"],"prefix":"10.1093","volume":"98","author":[{"given":"Samiha Abd El-Rahman","family":"Hussein","sequence":"first","affiliation":[{"name":"Assiut University, Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, 71526 Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanaa Mohamed Abd","family":"El-Wadood","sequence":"additional","affiliation":[{"name":"Assiut University, Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, 71526 Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abou-El Wafa","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Assiut University, Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, 71526 Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Abd El-Hamid","family":"Khorshed","sequence":"additional","affiliation":[{"name":"Assiut University, Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, 71526 Assiut, Egypt; Sohag University, Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, 82524 Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,27]]},"container-title":["Journal of AOAC INTERNATIONAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/98\/2\/354\/32425753\/jaoac0354.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/98\/2\/354\/32425753\/jaoac0354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T18:13:45Z","timestamp":1584641625000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaoac\/article\/98\/2\/354-360\/5654425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2015,3,1]]}},"URL":"https:\/\/doi.org\/10.5740\/jaoacint.14-179","relation":{},"ISSN":["1060-3271","1944-7922"],"issn-type":[{"value":"1060-3271","type":"print"},{"value":"1944-7922","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,3,1]]},"published":{"date-parts":[[2015,3,1]]}}}