{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:34:43Z","timestamp":1769520883102,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Newly established TLC-densitometric and RP-HPLC methods were developed and validated for the simultaneous determination of Piracetam (PIR) and Vincamine (VINC) in their pharmaceutical formulation and in the presence of PIR and VINC degradation products, PD and VD, respectively. The proposed TLC-densitometric method is based on the separation and quantitation of the studied components using a developing system that consists of chloroform\u2013methanol\u2013glacial acetic acid\u2013triethylamine (8 + 2 + 0.1 + 0.1, v\/v\/v\/v) on TLC silica gel 60 F254 plates, followed by densitometric scanning at 230 nm. On the other hand, the developed RP-HPLC method is based on the separation of the studied components using an isocratic elution of 0.05 M KH2PO4 (containing 0.1% triethylamine adjusted to pH 3 with orthophosphoric acid)\u2013methanol (95 + 5, v\/v) on a C8 column at a flow rate of 1 mL\/min with diode-array detection at 230 nm. The developed methods were validated according to International Conference on Harmonization guidelines and demonstrated good accuracy and precision. Moreover, the developed TLC-densitometric and RP-HPLC methods are suitable as stability-indicating assay methods for the simultaneous determination of PD and VD either in bulk powder or pharmaceutical formulation. The results were statistically compared with those obtained by the reported RP-HPLC method using t- and F-tests.<\/jats:p>","DOI":"10.5740\/jaoacint.16-0164","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T09:16:46Z","timestamp":1472462206000},"page":"1490-1498","source":"Crossref","is-referenced-by-count":13,"title":["Stability-Indicating TLC-Densitometric and HPLC Methods for the Simultaneous Determination of Piracetam and Vincamine in the Presence of Their Degradation Products"],"prefix":"10.1093","volume":"99","author":[{"given":"Amal B","family":"Ahmed","sequence":"first","affiliation":[{"name":"Nahda University, Faculty of Pharmacy, Analytical Chemistry Department, Sharq El-Nile, 62514 Beni-Suef, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha M","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"Beni-Suef University, Faculty of Pharmacy, Analytical Chemistry Department, Alshaheed Shehata Ahmad Hegazy St, 62514 Beni-Suef, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada S","family":"Abdelwahab","sequence":"additional","affiliation":[{"name":"Beni-Suef University, Faculty of Pharmacy, Analytical Chemistry Department, Alshaheed Shehata Ahmad Hegazy St, 62514 Beni-Suef, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fathy M","family":"Salama","sequence":"additional","affiliation":[{"name":"AL-Azhar University, Faculty of Pharmacy, Analytical Chemistry Department, Yosief Abbas St, 11651, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,27]]},"container-title":["Journal of AOAC INTERNATIONAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/99\/6\/1490\/32425981\/jaoac1490.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/99\/6\/1490\/32425981\/jaoac1490.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T13:30:16Z","timestamp":1594992616000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaoac\/article\/99\/6\/1490\/5658392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2016,11,1]]}},"URL":"https:\/\/doi.org\/10.5740\/jaoacint.16-0164","relation":{},"ISSN":["1060-3271","1944-7922"],"issn-type":[{"value":"1060-3271","type":"print"},{"value":"1944-7922","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,11,1]]},"published":{"date-parts":[[2016,11,1]]}}}