{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:13:19Z","timestamp":1761293599167},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An HPLC quadrupole time-of-flight (Q-TOF) MS method was developed for the identification of secondary metabolites in Leonurus turkestanicus V.I. Krecz. et Kuprian. Ethanolic and chloroform extracts from the plant\u2019s aerial parts were tested. A total of 16 compounds (iridoid glycosides, phenylpropanoids, flavonoids, and nitrogen-containing compounds, as well as diterpene acetate derivatives) were identified and tentatively characterized based on (or using) their retention times and UV and Q-TOF-MS data. Previously reported aucubin (1),6-deoxy-8-acetylharpagid(2), and stachydrine(13, 15)and homostachydrine isomers(14, 16)were identified, along with a lavandulifolioside isomer(3),verbascoside(4),rutin(5),3-O-kaempferol rutinoside (6), and an unknown diterpene acetate(8).Compounds3\u20136were detected for the first time in this plant. Additionally. antimicrobial activity was evaluated. No significant differences were found between ethanolic and chloroform extracts of L. turkestanicus; however, the alcoholic extract showed stronger antifungal activity [minimal inhibitory concentration (MIC) of 2.5\u20135 mg\/mL], whereas the chloroform extract showed stronger activity against the tested spore-forming Bacillus species (MIC 1.25\u20132.5 mg\/mL).<\/jats:p>","DOI":"10.5740\/jaoacint.17-0236","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T11:05:53Z","timestamp":1500030353000},"page":"1700-1705","source":"Crossref","is-referenced-by-count":12,"title":["Metabolic Profile of and Antimicrobial Activity in the Aerial Part of Leonurus turkestanicus V.I. Krecz. et Kuprian. from Kazakhstan"],"prefix":"10.1093","volume":"100","author":[{"given":"Olga","family":"Sermukhamedova","sequence":"first","affiliation":[{"name":"Asfendiyarov Kazakh National Medical University, 94 Tole bi St, Almaty 050012, Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof Kamil","family":"Wojtanowski","sequence":"additional","affiliation":[{"name":"Medical University of Lublin, Department of Pharmacognosy with Medicinal Plant Unit, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaros\u0142aw","family":"Widelski","sequence":"additional","affiliation":[{"name":"Medical University of Lublin, Department of Pharmacognosy with Medicinal Plant Unit, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Korona-G\u0142owniak","sequence":"additional","affiliation":[{"name":"Medical University of Lublin, Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosam O","family":"Elansary","sequence":"additional","affiliation":[{"name":"Alexandria University, Faculty of Agriculture (El-Shatby), Department of Floriculture, Ornamental Horticulture, and Garden Design, Alexandria, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuriyadda","family":"Sakipova","sequence":"additional","affiliation":[{"name":"Asfendiyarov Kazakh National Medical University, 94 Tole bi St, Almaty 050012, Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Malm","sequence":"additional","affiliation":[{"name":"Medical University of Lublin, Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazimierz","family":"G\u0142owniak","sequence":"additional","affiliation":[{"name":"University of Information Technology and Management in Rzesz\u00f3w, Department of Cosmetology, Kielnarowa, 36-020 Tyczyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystyna","family":"Skalicka-Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Medical University of Lublin, Department of Pharmacognosy with Medicinal Plant Unit, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,22]]},"container-title":["Journal of AOAC INTERNATIONAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/100\/6\/1700\/32426695\/jaoac1700.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/100\/6\/1700\/32426695\/jaoac1700.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T18:17:39Z","timestamp":1584641859000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaoac\/article\/100\/6\/1700-1705\/5654272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,11,22]]},"published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.5740\/jaoacint.17-0236","relation":{},"ISSN":["1060-3271","1944-7922"],"issn-type":[{"value":"1060-3271","type":"print"},{"value":"1944-7922","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,11,1]]},"published":{"date-parts":[[2017,11,1]]}}}