{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:07:40Z","timestamp":1788023260675,"version":"build-2784847793"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: QishenYiqi dripping pills (QSYQ), consisting of Salvia miltiorrhiza, Astragalus membranaceus, Panax notoginseng, and Dalbergia odorifera, is a widely used to treat ischemic cerebrovascular and hemorrhagic cerebrovascular in China. Objective: In this study, a rapid and sensitive ultra-HPLC coupled with a triple quadrupole MS (UHPLC-QQQ-MS) method was established for the simultaneous quantification of 19 bioactive components. Methods: Chromatographic separation was performed on an Agilent Eclipse Plus C18 Rapid Resolution High Definition (RRHD) column (2.1 \u00d7 50 mm, 1.8 \u03bcm) with a mobile phase composed of a 0.1% (v\/v) formic acid aqueous solution and acetonitrile in a gradient elution manner. A QQQ-MS was used in positive and negative ionization mode with multiple reactions monitoring for quantitative analysis. Results: The established methods were validated with linearity, precision, repeatability, stability, recovery, and matrix effect. All calibration curves exhibited excellent linear relationship with the correlation coefficient (r) &amp;gt;0.9985 for each analyte within the test range. This method was successfully applied to quantify target compounds of different structural types in 12 batches of QSYQ. Conclusions: The results suggest that the established method is rapid, sensitive, and reliable. The developed UHPLC-QQQ-MS method can provide scientific basis and reference to quality control and consistency evaluation of QSYQ sample and other formulations. Highlights: A rapid, sensitive, and reliable UHPLC-QQQ-MS method has been developed and validated for simultaneous determination of 19 compounds including phenolic acids, saponins, isoflavonoids, and tanshinones in QSYQ for the first time.<\/jats:p>","DOI":"10.5740\/jaoacint.18-0278","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T01:22:36Z","timestamp":1546910556000},"page":"1102-1111","source":"Crossref","is-referenced-by-count":11,"title":["Simultaneous Determination of 19 Bioactive Constituents in QishenYiqi Dropping Pills by Ultra-Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry"],"prefix":"10.1093","volume":"102","author":[{"given":"Qingling","family":"Xie","sequence":"first","affiliation":[{"name":"Human University of Chinese Medicine, School of Pharmacy, Innovative Materia Medica Research Institute, Changsha, TCM and Ethnomedicine Innovation & Development International Laboratory, People\u2019s Republic of China 410208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwen","family":"Yuan","sequence":"additional","affiliation":[{"name":"Human University of Chinese Medicine, School of Pharmacy, Innovative Materia Medica Research Institute, Changsha, TCM and Ethnomedicine Innovation & Development International Laboratory, People\u2019s Republic of China 410208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbei","family":"Liu","sequence":"additional","affiliation":[{"name":"Human University of Chinese Medicine, School of Pharmacy, Innovative Materia Medica Research Institute, Changsha, TCM and Ethnomedicine Innovation & Development International Laboratory, People\u2019s Republic of China 410208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Qiu","sequence":"additional","affiliation":[{"name":"Human University of Chinese Medicine, School of Pharmacy, Innovative Materia Medica Research Institute, Changsha, TCM and Ethnomedicine Innovation & Development International Laboratory, People\u2019s Republic of China 410208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Jian","sequence":"additional","affiliation":[{"name":"Human University of Chinese Medicine, School of Pharmacy, Innovative Materia Medica Research Institute, Changsha, TCM and Ethnomedicine Innovation & Development International Laboratory, People\u2019s Republic of China 410208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Human University of Chinese Medicine, School of Pharmacy, Innovative Materia Medica Research Institute, Changsha, TCM and Ethnomedicine Innovation & Development International Laboratory, People\u2019s Republic of China 410208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Peng","sequence":"additional","affiliation":[{"name":"Human University of Chinese Medicine, School of Pharmacy, Innovative Materia Medica Research Institute, Changsha, TCM and Ethnomedicine Innovation & Development International Laboratory, People\u2019s Republic of China 410208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tasly Academy, Tasly Holding Group Co., Ltd, Tianjin, People\u2019s Republic of China 300410"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Yang","sequence":"additional","affiliation":[{"name":"Tasly Academy, Tasly Holding Group Co., Ltd, Tianjin, People\u2019s Republic of China 300410; State Key Laboratory of Core Technology in Innovation Chinese Medicine, Tasly Pharmaceutical Group Co., Ltd, Tianjin, People\u2019s Republic of China 300410"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Human University of Chinese Medicine, School of Pharmacy, Innovative Materia Medica Research Institute, Changsha, TCM and Ethnomedicine Innovation & Development International Laboratory, People\u2019s Republic of China 410208"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,23]]},"container-title":["Journal of AOAC INTERNATIONAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/102\/4\/1102\/32428549\/jaoac1102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/102\/4\/1102\/32428549\/jaoac1102.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T18:19:16Z","timestamp":1584641956000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaoac\/article\/102\/4\/1102-1111\/5658266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,11,23]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.5740\/jaoacint.18-0278","relation":{},"ISSN":["1060-3271","1944-7922"],"issn-type":[{"value":"1060-3271","type":"print"},{"value":"1944-7922","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7,1]]},"published":{"date-parts":[[2019,7,1]]}}}