{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:30:44Z","timestamp":1791401444542,"version":"4.3.3"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ciguatera fish poisoning is the most extensive and difficult to control of the seafood poisonings. Tofacilitate monitoring of fish toxicity, toxin profiles were investigated by an LC\/MS\/MS method using 14reference toxins on eight representative species of fish collected in four different areas of the Pacific. Snappers and groupers from Okinawa contained ciguatoxin-1B (CTX1B) and two deoxy congeners at variablebut species-specific ratios, while red snapper, Lutjanus bohar, from Minamitorishima, and amberjack, Seriola dumerili, from Hawaii, contained both CTX1B-type and CTX3C-type toxins. Spotted knifejaw, Oplegnathus punctatus, from Okinawan waters, contained mainly CTX4A and CTX4B, but the same species caught at Miyazaki was contaminated primarily with the CTX3C-type toxins. Otherwise, the toxin profiles were consistently species-specific in fish collected from various locations around Okinawa over 20 years. The LC\/MS\/MSand mouse bioassay results agreed well, indicating the LC\/MS\/MS method is a promising alternative to themouse bioassay. Pure CTX1B and CTX3C were prepared for use in future LC\/MS\/MS analysis.<\/jats:p>","DOI":"10.5740\/jaoacint.sgeyogi","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T05:33:28Z","timestamp":1396416808000},"page":"398-402","source":"Crossref","is-referenced-by-count":79,"title":["Determination of Toxins Involved in Ciguatera Fish Poisoning in the Pacific by LC\/MS"],"prefix":"10.1093","volume":"97","author":[{"given":"Kentaro","family":"Yogi","sequence":"first","affiliation":[{"name":"University of the Ryukyus, Faculty ofMedicine, Department of Health Sciences, 207 Uehara,Nishihara, Okinawa 903-0215, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satsuki","family":"Sakugawa","sequence":"additional","affiliation":[{"name":"Okinawa Prefectural Institute of Health and Environment, 2085 Aza-Ozato, Ozato, Nanjo, Okinawa 901-1202, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomasa","family":"Oshiro","sequence":"additional","affiliation":[{"name":"National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Ikehara","sequence":"additional","affiliation":[{"name":"Nagasaki University, Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminori","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Central Research Laboratory Nippon Suisan Kaisha, Ltd, 559-6 Kitanomachi, Hachiouji-shi, Tokyo 192-0606, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yasumoto","sequence":"additional","affiliation":[{"name":"Japan Food Research Laboratories, 6-11-10 Nagayama, Tama-shi, Tokyo 206-0025; National Research Institute of Fisheries Science, 2-12-4 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-8648, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,27]]},"container-title":["Journal of AOAC INTERNATIONAL"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/97\/2\/398\/32425957\/jaoac0398.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jaoac\/article-pdf\/97\/2\/398\/32425957\/jaoac0398.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T18:20:53Z","timestamp":1584642053000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaoac\/article\/97\/2\/398-402\/5654717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,11,27]]},"published-print":{"date-parts":[[2014,3,1]]}},"URL":"https:\/\/doi.org\/10.5740\/jaoacint.sgeyogi","relation":{},"ISSN":["1060-3271","1944-7922"],"issn-type":[{"value":"1060-3271","type":"print"},{"value":"1944-7922","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,3,1]]},"published":{"date-parts":[[2014,3,1]]}}}